Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
RET	APPHRGVRQ	LUNG	800	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	Y
RET	DGPAPPHRG	LUNG	797	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	1	0	0	Y
RET	GPAPPHRGV	LUNG	798	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	13	12	0	Y
RET	GVRQIRLPA	LUNG	805	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	2	0	0	N
RET	HRGVRQIRL	LUNG	803	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	7	10	0	N
RET	PAPPHRGVR	LUNG	799	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	Y
RET	PHRGVRQIR	LUNG	802	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	N
RET	PPHRGVRQI	LUNG	801	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	7	13	0	N
RET	PPSSPPFHM	LARGE_INTESTINE	1048	p.A1046fs	c.3136_3137insC	Frame_Shift_Ins	6	0.11	LS411N	N	5	0	0	N
RET	PREPQSGAW	LUNG	817	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	1	0	0	N
RET	QLQLPGPPG	LUNG	834	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	N
RET	REPQSGAWL	LUNG	818	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	12	10	0	N
RET	RGVRQIRLP	LUNG	804	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	N
RET	RQIRLPAGL	LUNG	807	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	16	0	0	N
RET	VRQIRLPAG	LUNG	806	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	1	0	10	N