Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
RB1	ARLFLIMIK	LUNG	333	p.L337fs	c.1011_1011delG	Frame_Shift_Del	3	0.11	COLO668	Y	2	10	0	N
RB1	DARLFLIMI	LUNG	332	p.L337fs	c.1011_1011delG	Frame_Shift_Del	3	0.11	COLO668	Y	9	10	0	N
RB1	ENLIPILTT	LUNG	398	p.I401fs	c.1202_1202delT	Frame_Shift_Del	5	0.11	HCC33	N	0	0	0	Y
RB1	FLDHDNSSD	CENTRAL_NERVOUS_SYSTEM	336	p.K341fs	c.1021_1022delAA	Frame_Shift_Del	4	0.11	42MGBA	N	2	0	0	N
RB1	FLIMIKLFR	LUNG	336	p.L337fs	c.1011_1011delG	Frame_Shift_Del	5	0.11	COLO668	N	9	0	38	N
RB1	IMIKLFRLI	LUNG	338	p.L337fs	c.1011_1011delG	Frame_Shift_Del	5	0.11	COLO668	N	15	0	16	N
RB1	KNVYFKILY	ENDOMETRIUM	289	p.K294fs	c.880_880delA	Frame_Shift_Del	3	0.11	ISHIKAWAHERAKLIO02ER	N	7	0	0	N
RB1	LFLDHDNSS	CENTRAL_NERVOUS_SYSTEM	335	p.K341fs	c.1021_1022delAA	Frame_Shift_Del	3	0.11	42MGBA	N	0	0	8	N
RB1	LFLIMIKLF	LUNG	335	p.L337fs	c.1011_1011delG	Frame_Shift_Del	5	0.11	COLO668	N	7	0	14	N
RB1	LIMIKLFRL	LUNG	337	p.L337fs	c.1011_1011delG	Frame_Shift_Del	5	0.11	COLO668	N	15	0	24	N
RB1	LIPILTTAQ	LUNG	400	p.I401fs	c.1202_1202delT	Frame_Shift_Del	5	0.11	HCC33	N	0	0	20	N
RB1	MIKLFRLIL	LUNG	339	p.L337fs	c.1011_1011delG	Frame_Shift_Del	5	0.11	COLO668	Y	10	9	21	N
RB1	NLIPILTTA	LUNG	399	p.I401fs	c.1202_1202delT	Frame_Shift_Del	5	0.11	HCC33	Y	4	11	0	N
RB1	NVYFKILYL	ENDOMETRIUM	290	p.K294fs	c.880_880delA	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	Y	17	9	0	N
RB1	PSENLIPIL	LUNG	396	p.I401fs	c.1202_1202delT	Frame_Shift_Del	3	0.11	HCC33	N	0	0	0	N
RB1	RLFLIMIKL	LUNG	334	p.L337fs	c.1011_1011delG	Frame_Shift_Del	4	0.11	COLO668	Y	23	9	0	N
RB1	SENLIPILT	LUNG	397	p.I401fs	c.1202_1202delT	Frame_Shift_Del	4	0.11	HCC33	N	6	0	0	N
RB1	SLFYKKCIG	SOFT_TISSUE	648	p.K652fs	c.1954_1954delA	Frame_Shift_Del	3	0.11	SKUT1	N	0	0	0	N
RB1	VYFKILYLL	ENDOMETRIUM	291	p.K294fs	c.880_880delA	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	14	9	6	N
RB1	CGWSIGRLY	ENDOMETRIUM	83	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	6	0	0	N
RB1	CGWSIGRLY	OVARY	83	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	6	0	0	N
RB1	DHVRESLVN	ENDOMETRIUM	68	p.R71fs	c.211_212delAG	Frame_Shift_Del	4	0.22	COLO684	N	1	0	0	N
RB1	DHVRESLVN	OVARY	68	p.R71fs	c.211_212delAG	Frame_Shift_Del	4	0.22	COLO704	N	1	0	0	N
RB1	EKGTVGNLY	ENDOMETRIUM	94	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	3	0	0	N
RB1	EKGTVGNLY	OVARY	94	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	3	0	0	N
RB1	ESFICGWSI	ENDOMETRIUM	79	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	6	0	0	N
RB1	ESFICGWSI	OVARY	79	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	6	0	0	N
RB1	ESLVNLGES	ENDOMETRIUM	72	p.R71fs	c.211_212delAG	Frame_Shift_Del	4	0.22	COLO684	N	2	0	0	N
RB1	ESLVNLGES	OVARY	72	p.R71fs	c.211_212delAG	Frame_Shift_Del	4	0.22	COLO704	N	2	0	0	N
RB1	FICGWSIGR	ENDOMETRIUM	81	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	8	0	3	N
RB1	FICGWSIGR	OVARY	81	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	8	0	3	N
RB1	GESFICGWS	ENDOMETRIUM	78	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	4	0	0	N
RB1	GESFICGWS	OVARY	78	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	4	0	0	N
RB1	GNLYLYCSS	ENDOMETRIUM	99	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	1	0	0	N
RB1	GNLYLYCSS	OVARY	99	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	1	0	0	N
RB1	GRLYSKEKG	ENDOMETRIUM	88	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	1	0	0	N
RB1	GRLYSKEKG	OVARY	88	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	1	0	0	N
RB1	GTVGNLYLY	ENDOMETRIUM	96	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	Y	8	13	0	N
RB1	GTVGNLYLY	OVARY	96	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	Y	8	13	0	N
RB1	GWSIGRLYS	ENDOMETRIUM	84	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	0	N
RB1	GWSIGRLYS	OVARY	84	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	0	N
RB1	HVRESLVNL	ENDOMETRIUM	69	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	Y	7	11	0	N
RB1	HVRESLVNL	OVARY	69	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	Y	7	11	0	N
RB1	ICGWSIGRL	ENDOMETRIUM	82	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	6	0	0	N
RB1	ICGWSIGRL	OVARY	82	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	6	0	0	N
RB1	IGRLYSKEK	ENDOMETRIUM	87	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	0	0	2	N
RB1	IGRLYSKEK	OVARY	87	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	0	0	2	N
RB1	KEKGTVGNL	ENDOMETRIUM	93	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	Y	9	13	0	N
RB1	KEKGTVGNL	OVARY	93	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	Y	9	13	0	N
RB1	KGTVGNLYL	ENDOMETRIUM	95	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	10	0	0	N
RB1	KGTVGNLYL	OVARY	95	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	10	0	0	N
RB1	LGESFICGW	ENDOMETRIUM	77	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	3	0	0	N
RB1	LGESFICGW	OVARY	77	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	3	0	0	N
RB1	LVNLGESFI	ENDOMETRIUM	74	p.R71fs	c.211_212delAG	Frame_Shift_Del	3	0.22	COLO684	Y	9	10	3	N
RB1	LVNLGESFI	OVARY	74	p.R71fs	c.211_212delAG	Frame_Shift_Del	3	0.22	COLO704	Y	9	10	3	N
RB1	LYSKEKGTV	ENDOMETRIUM	90	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	3	0	5	N
RB1	LYSKEKGTV	OVARY	90	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	3	0	5	N
RB1	NLGESFICG	ENDOMETRIUM	76	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	0	0	0	N
RB1	NLGESFICG	OVARY	76	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	0	0	0	N
RB1	PDHVRESLV	ENDOMETRIUM	67	p.R71fs	c.211_212delAG	Frame_Shift_Del	3	0.22	COLO684	N	1	0	0	N
RB1	PDHVRESLV	OVARY	67	p.R71fs	c.211_212delAG	Frame_Shift_Del	3	0.22	COLO704	N	1	0	0	N
RB1	RESLVNLGE	ENDOMETRIUM	71	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	0	0	0	N
RB1	RESLVNLGE	OVARY	71	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	0	0	0	N
RB1	RLYSKEKGT	ENDOMETRIUM	89	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	4	0	0	Y
RB1	RLYSKEKGT	OVARY	89	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	4	0	0	Y
RB1	SFICGWSIG	ENDOMETRIUM	80	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	0	N
RB1	SFICGWSIG	OVARY	80	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	0	N
RB1	SIGRLYSKE	ENDOMETRIUM	86	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	0	N
RB1	SIGRLYSKE	OVARY	86	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	0	N
RB1	SKEKGTVGN	ENDOMETRIUM	92	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	1	0	0	N
RB1	SKEKGTVGN	OVARY	92	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	1	0	0	N
RB1	SLVNLGESF	ENDOMETRIUM	73	p.R71fs	c.211_212delAG	Frame_Shift_Del	3	0.22	COLO684	N	4	0	0	N
RB1	SLVNLGESF	OVARY	73	p.R71fs	c.211_212delAG	Frame_Shift_Del	3	0.22	COLO704	N	4	0	0	N
RB1	TVGNLYLYC	ENDOMETRIUM	97	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	3	0	0	N
RB1	TVGNLYLYC	OVARY	97	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	3	0	0	N
RB1	VGNLYLYCS	ENDOMETRIUM	98	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	0	0	8	N
RB1	VGNLYLYCS	OVARY	98	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	0	0	8	N
RB1	VNLGESFIC	ENDOMETRIUM	75	p.R71fs	c.211_212delAG	Frame_Shift_Del	4	0.22	COLO684	N	0	0	6	N
RB1	VNLGESFIC	OVARY	75	p.R71fs	c.211_212delAG	Frame_Shift_Del	4	0.22	COLO704	N	0	0	6	N
RB1	VRESLVNLG	ENDOMETRIUM	70	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO684	N	1	0	6	N
RB1	VRESLVNLG	OVARY	70	p.R71fs	c.211_212delAG	Frame_Shift_Del	5	0.22	COLO704	N	1	0	6	N
RB1	WSIGRLYSK	ENDOMETRIUM	85	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	Y	5	12	2	N
RB1	WSIGRLYSK	OVARY	85	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	Y	5	12	2	N
RB1	YSKEKGTVG	ENDOMETRIUM	91	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO684	N	2	0	0	Y
RB1	YSKEKGTVG	OVARY	91	p.R71fs	c.211_212delAG	Frame_Shift_Del	6	0.22	COLO704	N	2	0	0	Y
RB1	ALEVVMVHI	LUNG	490	p.A496fs	c.1486_1487insT	Frame_Shift_Ins	3	0.11	CPCN	Y	6	16	0	N