Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
PTEN	AELAILSLW	CENTRAL_NERVOUS_SYSTEM	208	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	7	0	0	N
PTEN	AILSLWSAS	CENTRAL_NERVOUS_SYSTEM	211	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	0	0	0	N
PTEN	CSVAELAIL	CENTRAL_NERVOUS_SYSTEM	205	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	Y	13	11	0	N
PTEN	ELAILSLWS	CENTRAL_NERVOUS_SYSTEM	209	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	0	0	0	N
PTEN	ETIQCSVAE	CENTRAL_NERVOUS_SYSTEM	201	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	0	0	0	N
PTEN	IKTKPTDTF	ENDOMETRIUM	329	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	4	0	0	N
PTEN	IQCSVAELA	CENTRAL_NERVOUS_SYSTEM	203	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	4	0	4	N
PTEN	KPTDTFLQI	ENDOMETRIUM	332	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	Y	14	10	0	N
PTEN	KTKPTDTFL	ENDOMETRIUM	330	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	11	0	0	N
PTEN	LAILSLWSA	CENTRAL_NERVOUS_SYSTEM	210	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	7	0	10	N
PTEN	LYQDQRKPQ	BREAST	278	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	6	0.11	CAMA1	N	0	0	7	N
PTEN	MILTKQIKT	ENDOMETRIUM	323	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	2	0	2	N
PTEN	NTLYQDQRK	BREAST	276	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	6	0.11	CAMA1	N	3	0	0	N
PTEN	PFVKILTNG	LARGE_INTESTINE	103	p.F104fs	c.310_310delT	Frame_Shift_Del	6	0.11	LS411N	N	0	0	0	N
PTEN	PLKTITHHS	BREAST	89	p.P89fs	c.267_267delT	Frame_Shift_Del	6	0.11	HCC70	N	0	0	0	N
PTEN	PTDTFLQIL	ENDOMETRIUM	333	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	2	0	0	N
PTEN	QCSVAELAI	CENTRAL_NERVOUS_SYSTEM	204	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	1	0	0	N
PTEN	QIKTKPTDT	ENDOMETRIUM	328	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	1	0	0	N
PTEN	QYPLKTITH	BREAST	87	p.P89fs	c.267_267delT	Frame_Shift_Del	6	0.11	HCC70	N	0	0	0	N
PTEN	SVAELAILS	CENTRAL_NERVOUS_SYSTEM	206	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	0	0	0	N
PTEN	TDTFLQILR	ENDOMETRIUM	334	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	1	0	0	N
PTEN	TIQCSVAEL	CENTRAL_NERVOUS_SYSTEM	202	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	Y	9	9	0	N
PTEN	TKPTDTFLQ	ENDOMETRIUM	331	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	0	0	0	N
PTEN	TKQIKTKPT	ENDOMETRIUM	326	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	1	0	0	N
PTEN	TLYQDQRKP	BREAST	277	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	7	0.11	CAMA1	N	0	0	0	N
PTEN	VAELAILSL	CENTRAL_NERVOUS_SYSTEM	207	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	12	0	0	N
PTEN	VNTLYQDQR	BREAST	275	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	6	0.11	CAMA1	N	2	0	0	N
PTEN	YPLKTITHH	BREAST	88	p.P89fs	c.267_267delT	Frame_Shift_Del	6	0.11	HCC70	N	3	0	4	N
PTEN	YQDQRKPQK	BREAST	279	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	6	0.11	CAMA1	N	5	0	0	N
PTEN	ATGRQVHVL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	233	p.T232fs	c.696_697insG	Frame_Shift_Ins	6	0.11	P31FUJ	Y	5	15	0	N
PTEN	CIFITSGQI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	138	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	Y	7	9	0	N
PTEN	CNDMCIFIT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	134	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	0	N
PTEN	CYGISCRKT	STOMACH	34	p.R11fs	c.32_33insA	Frame_Shift_Ins	7	0.11	SH10TC	N	1	0	0	N
PTEN	DMCIFITSG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	136	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	0	N
PTEN	EISRGWIRL	STOMACH	15	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	Y	3	9	0	N
PTEN	FITSGQIFK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	140	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	Y	6	10	2	N
PTEN	FLWGSKDQR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	155	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	10	0	1	N
PTEN	FYGGSKDQR	OVARY	154	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.11	OVK18	N	3	0	1	N
PTEN	GGSKDQRQK	OVARY	156	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.11	OVK18	N	0	0	0	N
PTEN	GPRFLWGSK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	152	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	0	N
PTEN	GQIFKGTRG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	144	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	0	N
PTEN	GRPNWCNDM	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	129	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	7	0.11	U937	Y	3	9	0	N
PTEN	GWIRLRLDL	STOMACH	19	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	7	0	0	N
PTEN	HYCYGISCR	STOMACH	32	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	Y	2	9	0	N
PTEN	IFITSGQIF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	139	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	Y	7	10	5	N
PTEN	IFKGTRGPR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	146	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	2	0	0	N
PTEN	IRLRLDLYL	STOMACH	21	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	Y	11	9	10	N
PTEN	ISRGWIRLR	STOMACH	16	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	Y	3	9	0	N
PTEN	ITSGQIFKG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	141	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	0	N
PTEN	KGRPNWCND	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	128	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	0	N
PTEN	KHYCYGISC	STOMACH	31	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	1	0	0	N
PTEN	KKGSNYSQS	SKIN	163	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.11	HS944T	N	1	0	0	Y
PTEN	KQKEISRGW	STOMACH	12	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	5	0	0	N
PTEN	LSKHYCYGI	STOMACH	29	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	6	0	0	N
PTEN	LWGSKDQRQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	156	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	0	N
PTEN	MCIFITSGQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	137	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	20	N
PTEN	NDMCIFITS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	135	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	0	N
PTEN	NWCNDMCIF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	132	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	2	0	0	N
PTEN	PNWCNDMCI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	131	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	3	0	0	N
PTEN	PRFLWGSKD	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	153	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	0	N
PTEN	PTATGRQVH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	231	p.T232fs	c.696_697insG	Frame_Shift_Ins	6	0.11	P31FUJ	N	0	0	0	N
PTEN	QIFKGTRGP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	145	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	0	N
PTEN	QKEISRGWI	STOMACH	13	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	1	0	0	N
PTEN	RFLWGSKDQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	154	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	0	0	0	N
PTEN	RGPRFLWGS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	151	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	0	N
PTEN	RGWIRLRLD	STOMACH	18	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	0	0	0	N
PTEN	RKQKEISRG	STOMACH	11	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	0	0	0	N
PTEN	RPNWCNDMC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	130	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	7	0.11	U937	N	5	0	0	N
PTEN	SGQIFKGTR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	143	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	7	0.11	U937	N	1	0	0	N
PTEN	SKHYCYGIS	STOMACH	30	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	1	0	0	N
PTEN	SRGWIRLRL	STOMACH	17	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	Y	8	10	0	N
PTEN	SRKQKEISR	STOMACH	10	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	Y	3	9	0	N
PTEN	TATGRQVHV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	232	p.T232fs	c.696_697insG	Frame_Shift_Ins	7	0.11	P31FUJ	N	5	0	0	N
PTEN	TRGPRFLWG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	150	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	0	N
PTEN	TSGQIFKGT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	142	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	0	N
PTEN	VSRKQKEIS	STOMACH	9	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	0	0	9	N
PTEN	WCNDMCIFI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	133	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	Y	6	10	7	N
PTEN	WGSKDQRQK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	157	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.11	U937	N	1	0	5	N
PTEN	WIRLRLDLY	STOMACH	20	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	Y	8	12	0	N
PTEN	YCYGISCRK	STOMACH	33	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	5	0	0	N
PTEN	YGGSKDQRQ	OVARY	155	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.11	OVK18	N	1	0	0	N
PTEN	YLSKHYCYG	STOMACH	28	p.R11fs	c.32_33insA	Frame_Shift_Ins	6	0.11	SH10TC	N	3	0	2	N
PTEN	DQRQKGSNY	OVARY	160	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.22	OVK18	N	5	0	0	Y
PTEN	DQRQKGSNY	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	161	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.22	U937	N	5	0	0	Y
PTEN	GSKDQRQKG	OVARY	157	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.22	OVK18	Y	0	11	0	N
PTEN	GSKDQRQKG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	158	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.22	U937	Y	0	11	0	N
PTEN	KDQRQKGSN	OVARY	159	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.22	OVK18	N	1	0	0	N
PTEN	KDQRQKGSN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	160	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.22	U937	N	1	0	0	N
PTEN	QKGSNYSQS	OVARY	163	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.22	OVK18	N	1	0	0	Y
PTEN	QKGSNYSQS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	164	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.22	U937	N	1	0	0	Y
PTEN	RQKGSNYSQ	OVARY	162	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.22	OVK18	N	0	0	0	Y
PTEN	RQKGSNYSQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	163	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.22	U937	N	0	0	0	Y
PTEN	SKDQRQKGS	OVARY	158	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.22	OVK18	N	1	0	0	N
PTEN	SKDQRQKGS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	159	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.22	U937	N	1	0	0	N
PTEN	GSNYSQSEA	SKIN	165	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.33	HS944T	N	1	0	0	N
PTEN	GSNYSQSEA	OVARY	165	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.33	OVK18	N	1	0	0	N
PTEN	GSNYSQSEA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	166	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.33	U937	N	1	0	0	N
PTEN	KGSNYSQSE	SKIN	164	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.33	HS944T	N	0	0	0	Y
PTEN	KGSNYSQSE	OVARY	164	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.33	OVK18	N	0	0	0	Y
PTEN	KGSNYSQSE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	165	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.33	U937	N	0	0	0	Y
PTEN	NYSQSEALC	SKIN	167	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.33	HS944T	N	1	0	0	N
PTEN	NYSQSEALC	OVARY	167	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.33	OVK18	N	1	0	0	N
PTEN	NYSQSEALC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	168	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.33	U937	N	1	0	0	N
PTEN	QSEALCVLL	SKIN	170	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.33	HS944T	Y	9	9	0	N
PTEN	QSEALCVLL	OVARY	170	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.33	OVK18	Y	9	9	0	N
PTEN	QSEALCVLL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	171	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.33	U937	Y	9	9	0	N
PTEN	SNYSQSEAL	SKIN	166	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.33	HS944T	N	10	0	0	N
PTEN	SNYSQSEAL	OVARY	166	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.33	OVK18	N	10	0	0	N
PTEN	SNYSQSEAL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	167	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.33	U937	N	10	0	0	N
PTEN	SQSEALCVL	SKIN	169	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.33	HS944T	Y	14	11	0	N
PTEN	SQSEALCVL	OVARY	169	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.33	OVK18	Y	14	11	0	N
PTEN	SQSEALCVL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	170	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.33	U937	Y	14	11	0	N
PTEN	YSQSEALCV	SKIN	168	p.D162fs	c.486_487insA	Frame_Shift_Ins	6	0.33	HS944T	N	6	0	2	N
PTEN	YSQSEALCV	OVARY	168	p.Y155fs	c.465_466insG	Frame_Shift_Ins	6	0.33	OVK18	N	6	0	2	N
PTEN	YSQSEALCV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	169	p.G129fs	c.387_388insCGCC	Frame_Shift_Ins	6	0.33	U937	N	6	0	2	N