Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NF1 | EIWTRQAWK | ENDOMETRIUM | 1066 | p.V1061fs | c.3183_3183delA | Frame_Shift_Del | 6 | 0.11 | HEC59 | Y | 4 | 13 | 0 | N | ||||||||||||
| NF1 | FEATAWPVK | SOFT_TISSUE | 1275 | p.F1275fs | c.3825_3825delC | Frame_Shift_Del | 6 | 0.11 | SKLMS1 | N | 3 | 0 | 0 | N | ||||||||||||
| NF1 | QEIWTRQAW | ENDOMETRIUM | 1065 | p.V1061fs | c.3183_3183delA | Frame_Shift_Del | 6 | 0.11 | HEC59 | Y | 5 | 9 | 0 | N | ||||||||||||
| NF1 | GIYSTNCSG | CENTRAL_NERVOUS_SYSTEM | 1249 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | TM31 | N | 0 | 0 | 0 | N | ||||||||||||
| NF1 | GIYSTNCSG | CENTRAL_NERVOUS_SYSTEM | 1249 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | U87MG | N | 0 | 0 | 0 | N | ||||||||||||
| NF1 | ILGIYSTNC | CENTRAL_NERVOUS_SYSTEM | 1247 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | TM31 | N | 4 | 0 | 10 | N | ||||||||||||
| NF1 | ILGIYSTNC | CENTRAL_NERVOUS_SYSTEM | 1247 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | U87MG | N | 4 | 0 | 10 | N | ||||||||||||
| NF1 | LGIYSTNCS | CENTRAL_NERVOUS_SYSTEM | 1248 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | TM31 | N | 0 | 0 | 34 | N | ||||||||||||
| NF1 | LGIYSTNCS | CENTRAL_NERVOUS_SYSTEM | 1248 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | U87MG | N | 0 | 0 | 34 | N | ||||||||||||
| NF1 | LILGIYSTN | CENTRAL_NERVOUS_SYSTEM | 1246 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | TM31 | N | 0 | 0 | 0 | Y | ||||||||||||
| NF1 | LILGIYSTN | CENTRAL_NERVOUS_SYSTEM | 1246 | p.L1246fs | c.3737_3740delTGTT | Frame_Shift_Del | 6 | 0.22 | U87MG | N | 0 | 0 | 0 | Y | ||||||||||||
| NF1 | YIQCGLCKI | LUNG | 182 | p.I183fs | c.548_549insA | Frame_Shift_Ins | 6 | 0.11 | NCIH1838 | N | 9 | 0 | 2 | N | ||||||||||||
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