Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NCOA3 | HKNYCSYLP | ENDOMETRIUM | 618 | p.K619fs | c.1855_1855delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| NCOA3 | PVLLMTGVI | ENDOMETRIUM | 626 | p.K619fs | c.1855_1855delA | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| NCOA3 | QYIDSRWLM | ENDOMETRIUM | 331 | p.T330fs | c.989_989delC | Frame_Shift_Del | 6 | 0.11 | MFE319 | Y | 3 | 10 | 0 | N | ||||||||||||
| NCOA3 | TQYIDSRWL | ENDOMETRIUM | 330 | p.T330fs | c.989_989delC | Frame_Shift_Del | 6 | 0.11 | MFE319 | Y | 13 | 14 | 0 | N | ||||||||||||
| NCOA3 | YIDSRWLME | ENDOMETRIUM | 332 | p.T330fs | c.989_989delC | Frame_Shift_Del | 6 | 0.11 | MFE319 | N | 2 | 0 | 0 | N | ||||||||||||
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