Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAP3K4 | AVAMLSFQY | ENDOMETRIUM | 192 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | N | 6 | 0 | 0 | N | ||||||||||||
| MAP3K4 | FQMWISISL | ENDOMETRIUM | 179 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | Y | 18 | 10 | 25 | N | ||||||||||||
| MAP3K4 | KNQFQMWIS | ENDOMETRIUM | 176 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | N | 0 | 0 | 0 | N | ||||||||||||
| MAP3K4 | LPKNQFQMW | ENDOMETRIUM | 174 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | N | 7 | 0 | 0 | N | ||||||||||||
| MAP3K4 | NQFQMWISI | ENDOMETRIUM | 177 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | Y | 13 | 12 | 0 | N | ||||||||||||
| MAP3K4 | PKNQFQMWI | ENDOMETRIUM | 175 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | N | 5 | 0 | 0 | N | ||||||||||||
| MAP3K4 | QFQMWISIS | ENDOMETRIUM | 178 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | N | 0 | 0 | 0 | N | ||||||||||||
| MAP3K4 | QMWISISLT | ENDOMETRIUM | 180 | p.P175fs | c.525_525delA | Frame_Shift_Del | 6 | 0.11 | MFE296 | N | 5 | 0 | 0 | N | ||||||||||||
| MAP3K4 | AKKINSRCG | ENDOMETRIUM | 175 | p.H157fs | c.471_472insA | Frame_Shift_Ins | 6 | 0.11 | MFE319 | N | 0 | 0 | 0 | N | ||||||||||||
| MAP3K4 | FAKKINSRC | ENDOMETRIUM | 174 | p.H157fs | c.471_472insA | Frame_Shift_Ins | 6 | 0.11 | MFE319 | N | 7 | 0 | 1 | N | ||||||||||||
| MAP3K4 | IFAKKINSR | ENDOMETRIUM | 173 | p.H157fs | c.471_472insA | Frame_Shift_Ins | 6 | 0.11 | MFE319 | N | 2 | 0 | 4 | N | ||||||||||||
| MAP3K4 | KKINSRCGS | ENDOMETRIUM | 176 | p.H157fs | c.471_472insA | Frame_Shift_Ins | 6 | 0.11 | MFE319 | N | 1 | 0 | 0 | N | ||||||||||||
| MAP3K4 | LSGWIFAKK | ENDOMETRIUM | 169 | p.H157fs | c.471_472insA | Frame_Shift_Ins | 6 | 0.11 | MFE319 | N | 3 | 0 | 0 | N | ||||||||||||
| MAP3K4 | RLSGWIFAK | ENDOMETRIUM | 168 | p.H157fs | c.471_472insA | Frame_Shift_Ins | 6 | 0.11 | MFE319 | Y | 6 | 14 | 0 | N | ||||||||||||
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