Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
FLT3	DLGLLSAGS	LARGE_INTESTINE	980	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	3	0.33	GP2D	N	0	0	0	N
FLT3	DLGLLSAGS	LARGE_INTESTINE	980	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	3	0.33	HCT116	N	0	0	0	N
FLT3	DLGLLSAGS	LARGE_INTESTINE	980	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	3	0.33	LS411N	N	0	0	0	N
FLT3	GLLSAGSGR	LARGE_INTESTINE	982	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	5	0.33	GP2D	N	6	0	0	N
FLT3	GLLSAGSGR	LARGE_INTESTINE	982	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	5	0.33	HCT116	N	6	0	0	N
FLT3	GLLSAGSGR	LARGE_INTESTINE	982	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	5	0.33	LS411N	N	6	0	0	N
FLT3	LGLLSAGSG	LARGE_INTESTINE	981	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	4	0.33	GP2D	N	0	0	0	N
FLT3	LGLLSAGSG	LARGE_INTESTINE	981	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	4	0.33	HCT116	N	0	0	0	N
FLT3	LGLLSAGSG	LARGE_INTESTINE	981	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	4	0.33	LS411N	N	0	0	0	N
FLT3	LLSAGSGRR	LARGE_INTESTINE	983	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	6	0.33	GP2D	N	5	0	2	N
FLT3	LLSAGSGRR	LARGE_INTESTINE	983	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	6	0.33	HCT116	N	5	0	2	N
FLT3	LLSAGSGRR	LARGE_INTESTINE	983	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	6	0.33	LS411N	N	5	0	2	N
FLT3	LSAGSGRRF	LARGE_INTESTINE	984	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	6	0.33	GP2D	N	6	0	0	N
FLT3	LSAGSGRRF	LARGE_INTESTINE	984	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	6	0.33	HCT116	N	6	0	0	N
FLT3	LSAGSGRRF	LARGE_INTESTINE	984	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	6	0.33	LS411N	N	6	0	0	N
FLT3	MDLGLLSAG	LARGE_INTESTINE	979	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	2	0.33	GP2D	N	0	0	0	N
FLT3	MDLGLLSAG	LARGE_INTESTINE	979	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	2	0.33	HCT116	N	0	0	0	N
FLT3	MDLGLLSAG	LARGE_INTESTINE	979	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	2	0.33	LS411N	N	0	0	0	N
FLT3	SAGSGRRFV	LARGE_INTESTINE	985	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	5	0.33	GP2D	Y	3	9	0	N
FLT3	SAGSGRRFV	LARGE_INTESTINE	985	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	5	0.33	HCT116	Y	3	9	0	N
FLT3	SAGSGRRFV	LARGE_INTESTINE	985	p.S985fs	c.2955_2956delTC	Frame_Shift_Del	5	0.33	LS411N	Y	3	9	0	N