Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
CDH1	AHFLKTWFR	LARGE_INTESTINE	169	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	2	0	0	N
CDH1	AHFLKTWFR	LARGE_INTESTINE	169	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	2	0	0	N
CDH1	AHFLKTWFR	STOMACH	169	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	2	0	0	N
CDH1	AQKMKKAHF	LARGE_INTESTINE	163	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	7	0	0	N
CDH1	AQKMKKAHF	LARGE_INTESTINE	163	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	7	0	0	N
CDH1	AQKMKKAHF	STOMACH	163	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	7	0	0	N
CDH1	ARFSTASLA	LARGE_INTESTINE	186	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	Y	5	9	0	N
CDH1	ARFSTASLA	LARGE_INTESTINE	186	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	Y	5	9	0	N
CDH1	ARFSTASLA	STOMACH	186	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	Y	5	9	0	N
CDH1	ESKQNCSHF	LARGE_INTESTINE	134	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	Y	4	9	0	N
CDH1	ESKQNCSHF	LARGE_INTESTINE	134	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	Y	4	9	0	N
CDH1	ESKQNCSHF	STOMACH	134	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	Y	4	9	0	N
CDH1	FLESKQNCS	LARGE_INTESTINE	132	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	4	0	0	N
CDH1	FLESKQNCS	LARGE_INTESTINE	132	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	4	0	0	N
CDH1	FLESKQNCS	STOMACH	132	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	4	0	0	N
CDH1	FLKTWFRSN	LARGE_INTESTINE	171	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	3	0	0	N
CDH1	FLKTWFRSN	LARGE_INTESTINE	171	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	3	0	0	N
CDH1	FLKTWFRSN	STOMACH	171	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	3	0	0	N
CDH1	FLPSAAQKM	LARGE_INTESTINE	158	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	Y	11	9	8	N
CDH1	FLPSAAQKM	LARGE_INTESTINE	158	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	Y	11	9	8	N
CDH1	FLPSAAQKM	STOMACH	158	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	Y	11	9	8	N
CDH1	FSTASLAKE	LARGE_INTESTINE	188	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	1	0	0	N
CDH1	FSTASLAKE	LARGE_INTESTINE	188	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	1	0	0	N
CDH1	FSTASLAKE	STOMACH	188	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	1	0	0	N
CDH1	IRPPFLESK	LARGE_INTESTINE	128	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	Y	2	10	0	N
CDH1	IRPPFLESK	LARGE_INTESTINE	128	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	Y	2	10	0	N
CDH1	IRPPFLESK	STOMACH	128	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	Y	2	10	0	N
CDH1	KAHFLKTWF	LARGE_INTESTINE	168	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	7	0	0	N
CDH1	KAHFLKTWF	LARGE_INTESTINE	168	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	7	0	0	N
CDH1	KAHFLKTWF	STOMACH	168	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	7	0	0	N
CDH1	KKAHFLKTW	LARGE_INTESTINE	167	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	3	0	0	N
CDH1	KKAHFLKTW	LARGE_INTESTINE	167	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	3	0	0	N
CDH1	KKAHFLKTW	STOMACH	167	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	3	0	0	N
CDH1	KKARFSTAS	LARGE_INTESTINE	184	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	1	0	0	N
CDH1	KKARFSTAS	LARGE_INTESTINE	184	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	1	0	0	N
CDH1	KKARFSTAS	STOMACH	184	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	1	0	0	N
CDH1	KMKKAHFLK	LARGE_INTESTINE	165	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	6	0	0	N
CDH1	KMKKAHFLK	LARGE_INTESTINE	165	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	6	0	0	N
CDH1	KMKKAHFLK	STOMACH	165	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	6	0	0	N
CDH1	KQNCSHFPT	LARGE_INTESTINE	136	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	6	0	0	N
CDH1	KQNCSHFPT	LARGE_INTESTINE	136	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	6	0	0	N
CDH1	KQNCSHFPT	STOMACH	136	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	6	0	0	N
CDH1	KTKKARFST	LARGE_INTESTINE	182	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	2	0	0	N
CDH1	KTKKARFST	LARGE_INTESTINE	182	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	2	0	0	N
CDH1	KTKKARFST	STOMACH	182	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	2	0	0	N
CDH1	KTWFRSNPT	LARGE_INTESTINE	173	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	3	0	0	N
CDH1	KTWFRSNPT	LARGE_INTESTINE	173	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	3	0	0	N
CDH1	KTWFRSNPT	STOMACH	173	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	3	0	0	N
CDH1	LESKQNCSH	LARGE_INTESTINE	133	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	4	N
CDH1	LESKQNCSH	LARGE_INTESTINE	133	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	4	N
CDH1	LESKQNCSH	STOMACH	133	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	4	N
CDH1	LLLKEKQDG	LARGE_INTESTINE	205	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	17	N
CDH1	LLLKEKQDG	LARGE_INTESTINE	205	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	17	N
CDH1	LLLKEKQDG	STOMACH	205	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	17	N
CDH1	LPSAAQKMK	LARGE_INTESTINE	159	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	2	0	0	N
CDH1	LPSAAQKMK	LARGE_INTESTINE	159	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	2	0	0	N
CDH1	LPSAAQKMK	STOMACH	159	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	2	0	0	N
CDH1	MKKAHFLKT	LARGE_INTESTINE	166	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	1	0	0	N
CDH1	MKKAHFLKT	LARGE_INTESTINE	166	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	1	0	0	N
CDH1	MKKAHFLKT	STOMACH	166	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	1	0	0	N
CDH1	PFLESKQNC	LARGE_INTESTINE	131	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	0	N
CDH1	PFLESKQNC	LARGE_INTESTINE	131	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	0	N
CDH1	PFLESKQNC	STOMACH	131	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	0	N
CDH1	PPFLESKQN	LARGE_INTESTINE	130	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	0	N
CDH1	PPFLESKQN	LARGE_INTESTINE	130	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	0	N
CDH1	PPFLESKQN	STOMACH	130	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	0	N
CDH1	PSAAQKMKK	LARGE_INTESTINE	160	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	0	N
CDH1	PSAAQKMKK	LARGE_INTESTINE	160	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	0	N
CDH1	PSAAQKMKK	STOMACH	160	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	0	N
CDH1	PTKTKKARF	LARGE_INTESTINE	180	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	2	0	0	N
CDH1	PTKTKKARF	LARGE_INTESTINE	180	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	2	0	0	N
CDH1	PTKTKKARF	STOMACH	180	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	2	0	0	N
CDH1	QKMKKAHFL	LARGE_INTESTINE	164	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	7	0	0	N
CDH1	QKMKKAHFL	LARGE_INTESTINE	164	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	7	0	0	N
CDH1	QKMKKAHFL	STOMACH	164	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	7	0	0	N
CDH1	QNCSHFPTP	LARGE_INTESTINE	137	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	0	N
CDH1	QNCSHFPTP	LARGE_INTESTINE	137	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	0	N
CDH1	QNCSHFPTP	STOMACH	137	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	0	N
CDH1	RFSTASLAK	LARGE_INTESTINE	187	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	2	0	0	N
CDH1	RFSTASLAK	LARGE_INTESTINE	187	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	2	0	0	N
CDH1	RFSTASLAK	STOMACH	187	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	2	0	0	N
CDH1	RPPFLESKQ	LARGE_INTESTINE	129	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	0	N
CDH1	RPPFLESKQ	LARGE_INTESTINE	129	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	0	N
CDH1	RPPFLESKQ	STOMACH	129	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	0	N
CDH1	SKQNCSHFP	LARGE_INTESTINE	135	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	0	N
CDH1	SKQNCSHFP	LARGE_INTESTINE	135	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	0	N
CDH1	SKQNCSHFP	STOMACH	135	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	0	N
CDH1	STASLAKEL	LARGE_INTESTINE	189	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	Y	5	11	0	N
CDH1	STASLAKEL	LARGE_INTESTINE	189	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	Y	5	11	0	N
CDH1	STASLAKEL	STOMACH	189	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	Y	5	11	0	N
CDH1	TKKARFSTA	LARGE_INTESTINE	183	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	2	0	0	N
CDH1	TKKARFSTA	LARGE_INTESTINE	183	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	2	0	0	N
CDH1	TKKARFSTA	STOMACH	183	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	2	0	0	N
CDH1	TKTKKARFS	LARGE_INTESTINE	181	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	1	0	0	N
CDH1	TKTKKARFS	LARGE_INTESTINE	181	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	1	0	0	N
CDH1	TKTKKARFS	STOMACH	181	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	1	0	0	N
CDH1	TWFRSNPTK	LARGE_INTESTINE	174	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	GP2D	N	0	0	0	N
CDH1	TWFRSNPTK	LARGE_INTESTINE	174	p.V119fs	c.357_357delG	Frame_Shift_Del	6	0.33	HCT116	N	0	0	0	N
CDH1	TWFRSNPTK	STOMACH	174	p.R124fs	c.372_372delC	Frame_Shift_Del	6	0.33	IM95	N	0	0	0	N
CDH1	GTRDTSADP	STOMACH	577	p.T578fs	c.1732_1733insC	Frame_Shift_Ins	6	0.11	AGS	N	0	0	0	Y
CDH1	TRDTSADPV	STOMACH	578	p.T578fs	c.1732_1733insC	Frame_Shift_Ins	6	0.11	AGS	N	4	0	0	Y