Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
ALPK2	RTYGARGVQ	ENDOMETRIUM	523	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	AN3CA	N	0	0	0	N
ALPK2	RTYGARGVQ	OVARY	523	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	IGROV1	N	0	0	0	N
ALPK2	RTYGARGVQ	ENDOMETRIUM	523	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	JHUEM1	N	0	0	0	N
ALPK2	RTYGARGVQ	SOFT_TISSUE	523	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	SKUT1	N	0	0	0	N
ALPK2	RTYGARGVQ	LARGE_INTESTINE	523	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	SNU175	N	0	0	0	N
ALPK2	TYGARGVQG	ENDOMETRIUM	524	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	AN3CA	N	0	0	0	N
ALPK2	TYGARGVQG	OVARY	524	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	IGROV1	N	0	0	0	N
ALPK2	TYGARGVQG	ENDOMETRIUM	524	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	JHUEM1	N	0	0	0	N
ALPK2	TYGARGVQG	SOFT_TISSUE	524	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	SKUT1	N	0	0	0	N
ALPK2	TYGARGVQG	LARGE_INTESTINE	524	p.K523fs	c.1568_1568delA	Frame_Shift_Del	6	0.55	SNU175	N	0	0	0	N
ALPK2	RRYPSSLLC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	559	p.G522fs	c.1566_1567insG	Frame_Shift_Ins	6	0.11	KASUMI2	N	4	0	0	N
ALPK2	YNRRYPSSL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	557	p.G522fs	c.1566_1567insG	Frame_Shift_Ins	6	0.11	KASUMI2	N	9	0	4	N
ALPK2	ESPIHWDHN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	680	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	K562	N	1	0	0	N
ALPK2	ESPIHWDHN	LUNG	680	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH1105	N	1	0	0	N
ALPK2	ESPIHWDHN	LARGE_INTESTINE	680	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH716	N	1	0	0	N
ALPK2	ESPIHWDHN	OVARY	680	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NIHOVCAR3	N	1	0	0	N
ALPK2	ESPIHWDHN	OVARY	680	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	OAW28	N	1	0	0	N
ALPK2	ESPIHWDHN	OVARY	680	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	ONCODG1	N	1	0	0	N
ALPK2	FLLKLRRGP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	690	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	K562	N	2	0	18	N
ALPK2	FLLKLRRGP	LUNG	690	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH1105	N	2	0	18	N
ALPK2	FLLKLRRGP	LARGE_INTESTINE	690	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH716	N	2	0	18	N
ALPK2	FLLKLRRGP	OVARY	690	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NIHOVCAR3	N	2	0	18	N
ALPK2	FLLKLRRGP	OVARY	690	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	OAW28	N	2	0	18	N
ALPK2	FLLKLRRGP	OVARY	690	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	ONCODG1	N	2	0	18	N
ALPK2	HWDHNNFLL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	684	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	K562	Y	8	10	0	N
ALPK2	HWDHNNFLL	LUNG	684	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH1105	Y	8	10	0	N
ALPK2	HWDHNNFLL	LARGE_INTESTINE	684	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH716	Y	8	10	0	N
ALPK2	HWDHNNFLL	OVARY	684	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NIHOVCAR3	Y	8	10	0	N
ALPK2	HWDHNNFLL	OVARY	684	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	OAW28	Y	8	10	0	N
ALPK2	HWDHNNFLL	OVARY	684	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	ONCODG1	Y	8	10	0	N
ALPK2	LLKLRRGPQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	691	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	K562	N	2	0	11	N
ALPK2	LLKLRRGPQ	LUNG	691	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH1105	N	2	0	11	N
ALPK2	LLKLRRGPQ	LARGE_INTESTINE	691	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NCIH716	N	2	0	11	N
ALPK2	LLKLRRGPQ	OVARY	691	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	NIHOVCAR3	N	2	0	11	N
ALPK2	LLKLRRGPQ	OVARY	691	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	OAW28	N	2	0	11	N
ALPK2	LLKLRRGPQ	OVARY	691	p.P682fs	c.2045_2046insC	Frame_Shift_Ins	6	0.66	ONCODG1	N	2	0	11	N