Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
AKAP9	AAVFSWKRE	ENDOMETRIUM	1664	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
AKAP9	ADREAENTA	KIDNEY	620	p.E621fs	c.1863_1864delAT	Frame_Shift_Del	4	0.11	786O	N	4	0	0	N
AKAP9	AFRGAGSTK	ENDOMETRIUM	1655	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	1	10	0	N
AKAP9	AGSTKAAVF	ENDOMETRIUM	1659	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	6	0	0	N
AKAP9	AVFSWKREA	ENDOMETRIUM	1665	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	3	0	0	N
AKAP9	AVSLVNIIL	ENDOMETRIUM	1207	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	5	9	0	N
AKAP9	CSYFYRLYA	ENDOMETRIUM	1199	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	4	12	0	N
AKAP9	DREAENTAS	KIDNEY	621	p.E621fs	c.1863_1864delAT	Frame_Shift_Del	4	0.11	786O	N	1	0	0	N
AKAP9	EADREAENT	KIDNEY	619	p.E621fs	c.1863_1864delAT	Frame_Shift_Del	4	0.11	786O	N	2	0	0	N
AKAP9	ECSYFYRLY	ENDOMETRIUM	1198	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	4	0	0	N
AKAP9	EECSYFYRL	ENDOMETRIUM	1197	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	3	0.11	ISHIKAWAHERAKLIO02ER	Y	11	10	0	N
AKAP9	EGAFRGAGS	ENDOMETRIUM	1653	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	1	0	0	N
AKAP9	EREGAFRGA	ENDOMETRIUM	1651	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	1	0	0	N
AKAP9	ESQEADREA	KIDNEY	616	p.E621fs	c.1863_1864delAT	Frame_Shift_Del	3	0.11	786O	N	2	0	0	N
AKAP9	FRGAGSTKA	ENDOMETRIUM	1656	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	5	0	15	N
AKAP9	FSWKREAVL	ENDOMETRIUM	1667	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	Y	19	9	0	N
AKAP9	FYRLYAVSL	ENDOMETRIUM	1202	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	Y	9	10	12	N
AKAP9	GAFRGAGST	ENDOMETRIUM	1654	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	3	0	0	N
AKAP9	GAGSTKAAV	ENDOMETRIUM	1658	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	5	10	0	N
AKAP9	GSTKAAVFS	ENDOMETRIUM	1660	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
AKAP9	KAAVFSWKR	ENDOMETRIUM	1663	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	5	0	0	N
AKAP9	LVSEREGAF	ENDOMETRIUM	1648	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	3	0.11	ISHIKAWAHERAKLIO02ER	N	4	0	0	N
AKAP9	LYAVSLVNI	ENDOMETRIUM	1205	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	7	15	2	N
AKAP9	QEADREAEN	KIDNEY	618	p.E621fs	c.1863_1864delAT	Frame_Shift_Del	4	0.11	786O	N	4	0	0	N
AKAP9	REAENTASI	KIDNEY	622	p.E621fs	c.1863_1864delAT	Frame_Shift_Del	4	0.11	786O	Y	9	14	0	N
AKAP9	REGAFRGAG	ENDOMETRIUM	1652	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	0	0	0	Y
AKAP9	RGAGSTKAA	ENDOMETRIUM	1657	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	2	0	0	N
AKAP9	RLYAVSLVN	ENDOMETRIUM	1204	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	3	0	0	N
AKAP9	SEREGAFRG	ENDOMETRIUM	1650	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	N	1	0	0	N
AKAP9	SLVNIILLL	ENDOMETRIUM	1209	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	19	11	0	N
AKAP9	SQEADREAE	KIDNEY	617	p.E621fs	c.1863_1864delAT	Frame_Shift_Del	4	0.11	786O	N	0	0	0	N
AKAP9	STKAAVFSW	ENDOMETRIUM	1661	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	2	11	0	N
AKAP9	SYFYRLYAV	ENDOMETRIUM	1200	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	5	10	0	N
AKAP9	TKAAVFSWK	ENDOMETRIUM	1662	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	1	0	0	Y
AKAP9	TNYKINLKC	LARGE_INTESTINE	594	p.I598fs	c.1794_1794delA	Frame_Shift_Del	3	0.11	LOVO	N	0	0	0	N
AKAP9	VFSWKREAV	ENDOMETRIUM	1666	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	Y	3	10	0	N
AKAP9	VSEREGAFR	ENDOMETRIUM	1649	p.S1650fs	c.4950_4951delAG	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	4	0	0	N
AKAP9	VSLVNIILL	ENDOMETRIUM	1208	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	17	10	2	N
AKAP9	YAVSLVNII	ENDOMETRIUM	1206	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	5	0.11	ISHIKAWAHERAKLIO02ER	Y	15	9	7	N
AKAP9	YFYRLYAVS	ENDOMETRIUM	1201	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	N	3	0	5	N
AKAP9	YRLYAVSLV	ENDOMETRIUM	1203	p.Y1201fs	c.3603_3603delT	Frame_Shift_Del	4	0.11	ISHIKAWAHERAKLIO02ER	Y	8	9	36	N
AKAP9	ARMGGSQLS	ENDOMETRIUM	3741	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	4	0.33	HEC59	N	2	0	0	N
AKAP9	ARMGGSQLS	LARGE_INTESTINE	3741	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	4	0.33	SNU1040	N	2	0	0	N
AKAP9	ARMGGSQLS	LARGE_INTESTINE	3741	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	4	0.33	SW48	N	2	0	0	N
AKAP9	AVNMMCQHT	LARGE_INTESTINE	44	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC2A	N	2	0	0	N
AKAP9	AVNMMCQHT	LARGE_INTESTINE	44	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC4	N	2	0	0	N
AKAP9	AVNMMCQHT	STOMACH	44	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	TGBC11TKB	N	2	0	0	N
AKAP9	EKRQAVNMM	LARGE_INTESTINE	40	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC2A	N	2	0	0	N
AKAP9	EKRQAVNMM	LARGE_INTESTINE	40	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC4	N	2	0	0	N
AKAP9	EKRQAVNMM	STOMACH	40	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	TGBC11TKB	N	2	0	0	N
AKAP9	KKQKKREKR	LARGE_INTESTINE	34	p.K37fs	c.109_109delA	Frame_Shift_Del	3	0.33	SNUC2A	N	1	0	0	N
AKAP9	KKQKKREKR	LARGE_INTESTINE	34	p.K37fs	c.109_109delA	Frame_Shift_Del	3	0.33	SNUC4	N	1	0	0	N
AKAP9	KKQKKREKR	STOMACH	34	p.K37fs	c.109_109delA	Frame_Shift_Del	3	0.33	TGBC11TKB	N	1	0	0	N
AKAP9	KKREKRQAV	LARGE_INTESTINE	37	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC2A	Y	3	12	0	N
AKAP9	KKREKRQAV	LARGE_INTESTINE	37	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC4	Y	3	12	0	N
AKAP9	KKREKRQAV	STOMACH	37	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	TGBC11TKB	Y	3	12	0	N
AKAP9	KQKKREKRQ	LARGE_INTESTINE	35	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC2A	N	1	0	0	N
AKAP9	KQKKREKRQ	LARGE_INTESTINE	35	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC4	N	1	0	0	N
AKAP9	KQKKREKRQ	STOMACH	35	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	TGBC11TKB	N	1	0	0	N
AKAP9	KREKRQAVN	LARGE_INTESTINE	38	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC2A	N	2	0	0	N
AKAP9	KREKRQAVN	LARGE_INTESTINE	38	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC4	N	2	0	0	N
AKAP9	KREKRQAVN	STOMACH	38	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	TGBC11TKB	N	2	0	0	N
AKAP9	KRQAVNMMC	LARGE_INTESTINE	41	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC2A	N	2	0	0	N
AKAP9	KRQAVNMMC	LARGE_INTESTINE	41	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC4	N	2	0	0	N
AKAP9	KRQAVNMMC	STOMACH	41	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	TGBC11TKB	N	2	0	0	N
AKAP9	LARMGGSQL	ENDOMETRIUM	3740	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	3	0.33	HEC59	N	8	0	2	N
AKAP9	LARMGGSQL	LARGE_INTESTINE	3740	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	3	0.33	SNU1040	N	8	0	2	N
AKAP9	LARMGGSQL	LARGE_INTESTINE	3740	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	3	0.33	SW48	N	8	0	2	N
AKAP9	MGGSQLSRI	ENDOMETRIUM	3743	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	5	0.33	HEC59	N	8	0	2	N
AKAP9	MGGSQLSRI	LARGE_INTESTINE	3743	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	5	0.33	SNU1040	N	8	0	2	N
AKAP9	MGGSQLSRI	LARGE_INTESTINE	3743	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	5	0.33	SW48	N	8	0	2	N
AKAP9	NMMCQHTMI	LARGE_INTESTINE	46	p.K37fs	c.109_109delA	Frame_Shift_Del	6	0.33	SNUC2A	N	8	0	0	N
AKAP9	NMMCQHTMI	LARGE_INTESTINE	46	p.K37fs	c.109_109delA	Frame_Shift_Del	6	0.33	SNUC4	N	8	0	0	N
AKAP9	NMMCQHTMI	STOMACH	46	p.K37fs	c.109_109delA	Frame_Shift_Del	6	0.33	TGBC11TKB	N	8	0	0	N
AKAP9	QAVNMMCQH	LARGE_INTESTINE	43	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC2A	N	0	0	0	N
AKAP9	QAVNMMCQH	LARGE_INTESTINE	43	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC4	N	0	0	0	N
AKAP9	QAVNMMCQH	STOMACH	43	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	TGBC11TKB	N	0	0	0	N
AKAP9	QKKREKRQA	LARGE_INTESTINE	36	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC2A	N	2	0	0	N
AKAP9	QKKREKRQA	LARGE_INTESTINE	36	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC4	N	2	0	0	N
AKAP9	QKKREKRQA	STOMACH	36	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	TGBC11TKB	N	2	0	0	N
AKAP9	REKRQAVNM	LARGE_INTESTINE	39	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC2A	Y	8	10	0	N
AKAP9	REKRQAVNM	LARGE_INTESTINE	39	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	SNUC4	Y	8	10	0	N
AKAP9	REKRQAVNM	STOMACH	39	p.K37fs	c.109_109delA	Frame_Shift_Del	4	0.33	TGBC11TKB	Y	8	10	0	N
AKAP9	RMGGSQLSR	ENDOMETRIUM	3742	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	5	0.33	HEC59	N	7	0	0	N
AKAP9	RMGGSQLSR	LARGE_INTESTINE	3742	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	5	0.33	SNU1040	N	7	0	0	N
AKAP9	RMGGSQLSR	LARGE_INTESTINE	3742	p.M3743fs	c.11229_11229delG	Frame_Shift_Del	5	0.33	SW48	N	7	0	0	N
AKAP9	RQAVNMMCQ	LARGE_INTESTINE	42	p.K37fs	c.109_109delA	Frame_Shift_Del	6	0.33	SNUC2A	N	0	0	0	N
AKAP9	RQAVNMMCQ	LARGE_INTESTINE	42	p.K37fs	c.109_109delA	Frame_Shift_Del	6	0.33	SNUC4	N	0	0	0	N
AKAP9	RQAVNMMCQ	STOMACH	42	p.K37fs	c.109_109delA	Frame_Shift_Del	6	0.33	TGBC11TKB	N	0	0	0	N
AKAP9	VNMMCQHTM	LARGE_INTESTINE	45	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC2A	N	3	0	30	N
AKAP9	VNMMCQHTM	LARGE_INTESTINE	45	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	SNUC4	N	3	0	30	N
AKAP9	VNMMCQHTM	STOMACH	45	p.K37fs	c.109_109delA	Frame_Shift_Del	5	0.33	TGBC11TKB	N	3	0	30	N
AKAP9	VSERERGCF	PROSTATE	1649	p.S1650fs	c.4949_4950insAG	Frame_Shift_Ins	3	0.11	DU145	N	6	0	0	N
AKAP9	HLKEKNRQM	ENDOMETRIUM	2117	p.E2120fs	c.6358_6359insA	Frame_Shift_Ins	4	0.22	AN3CA	N	4	0	0	N
AKAP9	HLKEKNRQM	LARGE_INTESTINE	2117	p.E2120fs	c.6358_6359insA	Frame_Shift_Ins	4	0.22	LOVO	N	4	0	0	N
AKAP9	LKEKNRQMQ	ENDOMETRIUM	2118	p.E2120fs	c.6358_6359insA	Frame_Shift_Ins	4	0.22	AN3CA	N	0	0	9	N
AKAP9	LKEKNRQMQ	LARGE_INTESTINE	2118	p.E2120fs	c.6358_6359insA	Frame_Shift_Ins	4	0.22	LOVO	N	0	0	9	N
AKAP9	NHLKEKNRQ	ENDOMETRIUM	2116	p.E2120fs	c.6358_6359insA	Frame_Shift_Ins	3	0.22	AN3CA	N	0	0	0	N
AKAP9	NHLKEKNRQ	LARGE_INTESTINE	2116	p.E2120fs	c.6358_6359insA	Frame_Shift_Ins	3	0.22	LOVO	N	0	0	0	N