Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     665
XP_006717989                                                           19     665
NP_065882                                                              16    5631
NP_001269589                                                           16    5631
NP_001269590                                                           16    5631
NP_001269591                                                           16    5631
NP_001252541                                                           16    5631
NP_057368                                                              16    5631
NP_996882                                                              16    5631
XP_005261751                                                           16    5631
XP_005261749                                                           16    5631
XP_005261748                                                           16    5631
NP_783161                                                              16    7355
NP_776169                                                              16    7355
XP_006715921                                                           16    7355
XP_005250007                                                           16    7355
NP_002261                                                              15    9605
NP_694858                                                              15    9605
NP_525022                                                              15    9605
NP_115946                                                              15    9605
NP_775099                                                              15    9605
NP_056472                                                              15    9605
NP_001277255                                                           15    9605
NP_001277254                                                           15    9605
NP_065849                                                              15    9605
XP_005256994                                                           15    9605
XP_005256993                                                           15    9605
XP_005256992                                                           15    9605
XP_006721697                                                           15    9605
XP_006721696                                                           15    9605
XP_005256991                                                           15    9605
XP_005250953                                                           15    9605
XP_005250952                                                           15    9605
XP_005250951                                                           15    9605
XP_005248557                                                           15    9605
XP_005248558                                                           15    9605
NP_861452                                                              15    9605

>NP_000305
          Length = 403

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   YLVLTLTK 8
           YLVLTLTK
Sbjct: 315 YLVLTLTK 322



>XP_006717989
          Length = 388

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   YLVLTLTK 8
           YLVLTLTK
Sbjct: 300 YLVLTLTK 307



>NP_065882
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           +LVLT+T K
Sbjct: 666 HLVLTVTNK 674



>NP_001269589
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           +LVLT+T K
Sbjct: 666 HLVLTVTNK 674



>NP_001269590
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           +LVLT+T K
Sbjct: 616 HLVLTVTNK 624



>NP_001269591
          Length = 798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           +LVLT+T K
Sbjct: 666 HLVLTVTNK 674



>NP_001252541
          Length = 2371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  YLVLTLTKK 9
          YLV  LTKK
Sbjct: 15 YLVDNLTKK 23



>NP_057368
          Length = 2376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  YLVLTLTKK 9
          YLV  LTKK
Sbjct: 15 YLVDNLTKK 23



>NP_996882
          Length = 1551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  YLVLTLTKK 9
          YLV  LTKK
Sbjct: 15 YLVDNLTKK 23



>XP_005261751
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           +LVLT+T K
Sbjct: 666 HLVLTVTNK 674



>XP_005261749
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           +LVLT+T K
Sbjct: 693 HLVLTVTNK 701



>XP_005261748
          Length = 966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           +LVLT+T K
Sbjct: 701 HLVLTVTNK 709



>NP_783161
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           Y+++ LT+K
Sbjct: 358 YMIILLTRK 366



>NP_776169
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YLVLTLT 7
           YLVLTL+
Sbjct: 334 YLVLTLS 340



>XP_006715921
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           Y+++ LT+K
Sbjct: 358 YMIILLTRK 366



>XP_005250007
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKK 9
           Y+++ LT+K
Sbjct: 358 YMIILLTRK 366



>NP_002261
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YLVLTLTK 8
          YL+  LTK
Sbjct: 57 YLIFVLTK 64



>NP_694858
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YLVLTLTK 8
          YL+  LTK
Sbjct: 49 YLIFVLTK 56



>NP_525022
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 413 YLVLTL 418



>NP_115946
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 760 YLILTLLR 767



>NP_775099
          Length = 2595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LTLTKK 9
            LTLTKK
Sbjct: 1574 LTLTKK 1579



>NP_056472
          Length = 2277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LTLTKK 9
            LTLTKK
Sbjct: 1256 LTLTKK 1261



>NP_001277255
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 305 YLILTLLR 312



>NP_001277254
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 760 YLILTLLR 767



>NP_065849
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 803 YLILTLLR 810



>XP_005256994
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426



>XP_005256993
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 332 YLVLTL 337



>XP_005256992
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 332 YLVLTL 337



>XP_006721697
          Length = 1625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426



>XP_006721696
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426



>XP_005256991
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426



>XP_005250953
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 102 YLVCTLT 108



>XP_005250952
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 248 YLVCTLT 254



>XP_005250951
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 290 YLVCTLT 296



>XP_005248557
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YLVLTLTK 8
          YL+  LTK
Sbjct: 49 YLIFVLTK 56



>XP_005248558
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YLVLTLTK 8
          YL+  LTK
Sbjct: 57 YLIFVLTK 64



>NP_861452
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 353 YLVCTLT 359



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.139    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 344,979
Number of extensions: 418
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)