Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_597702                                                              18    1482
NP_291024                                                              16    5631
NP_001138417                                                           16    5631
NP_997190                                                              16    5631
NP_001138416                                                           16    5631
NP_001230166                                                           16    5631
NP_001164161                                                           16    5631
NP_066025                                                              16    5631
XP_005253094                                                           16    5631
XP_005253093                                                           16    5631
XP_005253092                                                           16    5631
XP_005253091                                                           16    5631
XP_005253090                                                           16    5631
XP_006718331                                                           16    5631
XP_005253089                                                           16    5631
XP_005251183                                                           16    5631
XP_006713883                                                           16    5631
NP_005238                                                              16    7355
NP_079390                                                              16    7355
NP_001127835                                                           16    7355
NP_056975                                                              16    7355
NP_001156001                                                           16    7355
XP_006719673                                                           16    7355
XP_005269218                                                           16    7355
XP_005269217                                                           16    7355
XP_006719672                                                           16    7355
XP_005269215                                                           16    7355
XP_005248806                                                           16    7355
XP_005248804                                                           16    7355
XP_005248803                                                           16    7355
XP_005248802                                                           16    7355
XP_005248801                                                           16    7355
XP_005248800                                                           16    7355
NP_001010860                                                           16    7355
NP_006556                                                              15    9605
NP_001449                                                              15    9605
NP_001120959                                                           15    9605
NP_055186                                                              15    9605
NP_001278407                                                           15    9605
NP_001159635                                                           15    9605
NP_647539                                                              15    9605
NP_001159632                                                           15    9605
NP_001159634                                                           15    9605
NP_001159633                                                           15    9605
NP_003395                                                              15    9605
NP_001997                                                              15    9605
NP_004791                                                              15    9605
NP_689762                                                              15    9605
NP_001035530                                                           15    9605
NP_079019                                                              15    9605
NP_689786                                                              15    9605
XP_006725063                                                           15    9605
XP_005259911                                                           15    9605
XP_005255832                                                           15    9605
XP_005251788                                                           15    9605
XP_005251787                                                           15    9605
XP_006716111                                                           15    9605
XP_006716110                                                           15    9605
XP_005250542                                                           15    9605
XP_006716109                                                           15    9605
XP_006715973                                                           15    9605
XP_005272199                                                           15    9605
XP_005271965                                                           15    9605
XP_006714368                                                           15    9605
NP_060120                                                              15    9605
NP_055644                                                              15    9605
>NP_597702
          Length = 1115

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    KTKRTEKR 9
            KTKR EKR
Sbjct: 996  KTKRVEKR 1003
>NP_291024
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KTKRTEKR 9
          KTK T+KR
Sbjct: 7  KTKTTKKR 14
>NP_001138417
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KTKRTEKR 9
          KTK T+KR
Sbjct: 7  KTKTTKKR 14
>NP_997190
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKRTEKR 9
           K+KRT+K+
Sbjct: 462 KSKRTDKK 469
>NP_001138416
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KTKRTEKR 9
          KTK T+KR
Sbjct: 7  KTKTTKKR 14
>NP_001230166
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TKTKRTEKR 9
           TK+K+++KR
Sbjct: 148 TKSKKSKKR 156
>NP_001164161
          Length = 807

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 453 KRTEKR 458
>NP_066025
          Length = 971

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 608 KRTEKR 613
>XP_005253094
          Length = 873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 453 KRTEKR 458
>XP_005253093
          Length = 919

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 499 KRTEKR 504
>XP_005253092
          Length = 953

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 608 KRTEKR 613
>XP_005253091
          Length = 987

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 567 KRTEKR 572
>XP_005253090
          Length = 999

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 579 KRTEKR 584
>XP_006718331
          Length = 1027

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 607 KRTEKR 612
>XP_005253089
          Length = 1028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRTEKR 9
           KRTEKR
Sbjct: 608 KRTEKR 613
>XP_005251183
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TKTKRTEKR 9
           TK+K+++KR
Sbjct: 148 TKSKKSKKR 156
>XP_006713883
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKRTEKR 9
           K+KRT+K+
Sbjct: 447 KSKRTDKK 454
>NP_005238
          Length = 239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           KT+RT+K
Sbjct: 168 KTRRTQK 174
>NP_079390
          Length = 2479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TKTKRTEK 8
            +KTK TEK
Sbjct: 2194 SKTKGTEK 2201
>NP_001127835
          Length = 1227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           KTKRT++
Sbjct: 827 KTKRTDR 833
>NP_056975
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TKTKRTEKR 9
           T  K+TEKR
Sbjct: 170 TGQKKTEKR 178
>NP_001156001
          Length = 1515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTKRTEKR 9
           T T+RTE++
Sbjct: 578 TNTERTEQK 586
>XP_006719673
          Length = 1997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TKTKRTEK 8
            +KTK TEK
Sbjct: 1712 SKTKGTEK 1719
>XP_005269218
          Length = 2009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TKTKRTEK 8
            +KTK TEK
Sbjct: 1724 SKTKGTEK 1731
>XP_005269217
          Length = 2353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TKTKRTEK 8
            +KTK TEK
Sbjct: 2225 SKTKGTEK 2232
>XP_006719672
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TKTKRTEK 8
            +KTK TEK
Sbjct: 2225 SKTKGTEK 2232
>XP_005269215
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TKTKRTEK 8
            +KTK TEK
Sbjct: 2225 SKTKGTEK 2232
>XP_005248806
          Length = 1317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTKRTEKR 9
           T T+RTE++
Sbjct: 604 TNTERTEQK 612
>XP_005248804
          Length = 1378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTKRTEKR 9
           T T+RTE++
Sbjct: 441 TNTERTEQK 449
>XP_005248803
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTKRTEKR 9
           T T+RTE++
Sbjct: 518 TNTERTEQK 526
>XP_005248802
          Length = 1515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTKRTEKR 9
           T T+RTE++
Sbjct: 578 TNTERTEQK 586
>XP_005248801
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTKRTEKR 9
           T T+RTE++
Sbjct: 604 TNTERTEQK 612
>XP_005248800
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTKRTEKR 9
           T T+RTE++
Sbjct: 604 TNTERTEQK 612
>NP_001010860
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTKRTEK 8
           T+TK TEK
Sbjct: 395 TQTKPTEK 402
>NP_006556
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           KTK+T+K
Sbjct: 203 KTKKTKK 209
>NP_001449
          Length = 2725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TKTKRTE 7
            T+T+RTE
Sbjct: 2186 TRTERTE 2192
>NP_001120959
          Length = 2692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TKTKRTE 7
            T+T+RTE
Sbjct: 2153 TRTERTE 2159
>NP_055186
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           KTK+TE+
Sbjct: 439 KTKKTEE 445
>NP_001278407
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           KTK+TE+
Sbjct: 378 KTKKTEE 384
>NP_001159635
          Length = 1090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1072 KSKKTEK 1078
>NP_647539
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KTKRTEKR 9
          KT+R EK+
Sbjct: 70 KTERNEKK 77
>NP_001159632
          Length = 1374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1356 KSKKTEK 1362
>NP_001159634
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1235 KSKKTEK 1241
>NP_001159633
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1278 KSKKTEK 1284
>NP_003395
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KTKRTEKR 9
          KT+R EK+
Sbjct: 70 KTERNEKK 77
>NP_001997
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKTKRTEKR 9
          T+ +RTE+R
Sbjct: 65 TRGRRTEER 73
>NP_004791
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TKTKRTEK 8
           TKT  TEK
Sbjct: 125 TKTYHTEK 132
>NP_689762
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KTK+ +KR
Sbjct: 229 KTKKQQKR 236
>NP_001035530
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KTK+ +KR
Sbjct: 312 KTKKQQKR 319
>NP_079019
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KT++ EKR
Sbjct: 519 KTRKIEKR 526
>NP_689786
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KT++ EKR
Sbjct: 219 KTRKDEKR 226
>XP_006725063
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KT++ EKR
Sbjct: 281 KTRKIEKR 288
>XP_005259911
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           KTK+TE+
Sbjct: 405 KTKKTEE 411
>XP_005255832
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           KTK+T+K
Sbjct: 203 KTKKTKK 209
>XP_005251788
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KTKRTEKR 9
          KT++ EKR
Sbjct: 90 KTRKDEKR 97
>XP_005251787
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KT++ EKR
Sbjct: 219 KTRKDEKR 226
>XP_006716111
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKRTEK 8
           K+K+TEK
Sbjct: 683 KSKKTEK 689
>XP_006716110
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1123 KSKKTEK 1129
>XP_005250542
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1339 KSKKTEK 1345
>XP_006716109
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1347 KSKKTEK 1353
>XP_006715973
          Length = 2632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TKTKRTE 7
            T+T+RTE
Sbjct: 2093 TRTERTE 2099
>XP_005272199
          Length = 1032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           K+K+TE R
Sbjct: 110 KSKKTENR 117
>XP_005271965
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KTK+ +KR
Sbjct: 312 KTKKQQKR 319
>XP_006714368
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           KT++ EKR
Sbjct: 281 KTRKIEKR 288
>NP_060120
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKRTEK 8
            K+K+TEK
Sbjct: 1080 KSKKTEK 1086
>NP_055644
          Length = 1031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTKRTEKR 9
           K+K+TE R
Sbjct: 110 KSKKTENR 117
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.108    0.260 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 486,124
Number of extensions: 986
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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