Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_115583                                                              17    3301
NP_001275763                                                           17    3301
XP_006722984                                                           17    3301
XP_006722983                                                           17    3301
XP_006711677                                                           17    3301
NP_078845                                                              17    3301
NP_003944                                                              17    3301
NP_001139663                                                           17    3301
NP_001106853                                                           16    5631
XP_006712889                                                           16    5631
NP_001180442                                                           16    7355
NP_001180443                                                           16    7355
NP_060434                                                              16    7355
NP_001229695                                                           16    7355
NP_004737                                                              16    7355
NP_001003809                                                           16    7355
NP_001229693                                                           16    7355
NP_001229690                                                           16    7355
NP_001229692                                                           16    7355
NP_001229691                                                           16    7355
NP_853514                                                              16    7355
NP_821158                                                              16    7355
NP_001229694                                                           16    7355
NP_005112                                                              16    7355
NP_001180444                                                           16    7355
NP_001167627                                                           16    7355
XP_005258233                                                           16    7355
XP_005258232                                                           16    7355
XP_005258231                                                           16    7355
XP_006722430                                                           16    7355
XP_005258230                                                           16    7355
XP_005258229                                                           16    7355
XP_005258228                                                           16    7355
XP_005269598                                                           16    7355
XP_006712109                                                           16    7355
NP_001116512                                                           16    7355
NP_940820                                                              15    9605
NP_001028776                                                           15    9605
NP_001028777                                                           15    9605
NP_055266                                                              15    9605
NP_001263309                                                           15    9605
NP_057733                                                              15    9605
NP_076425                                                              15    9605
NP_078978                                                              15    9605
XP_005255569                                                           15    9605
XP_005255568                                                           15    9605
XP_006715751                                                           15    9605
XP_005249757                                                           15    9605
XP_006715750                                                           15    9605
XP_006713833                                                           15    9605
XP_006713832                                                           15    9605
XP_006713831                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTAYTPR 9
            SAL AYTPR
Sbjct: 1384 SALPAYTPR 1392
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTAYTPR 9
            SAL AYTPR
Sbjct: 1179 SALPAYTPR 1187
>NP_115583
          Length = 657

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ALTAYTP 8
           ALTAY+P
Sbjct: 579 ALTAYSP 585
>NP_001275763
          Length = 625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ALTAYTP 8
           ALTAY+P
Sbjct: 547 ALTAYSP 553
>XP_006722984
          Length = 303

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ALTAYTP 8
           ALTAY+P
Sbjct: 225 ALTAYSP 231
>XP_006722983
          Length = 625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ALTAYTP 8
           ALTAY+P
Sbjct: 547 ALTAYSP 553
>XP_006711677
          Length = 339

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SALTAYTPR 9
           SAL  YTP+
Sbjct: 106 SALEVYTPK 114
>NP_078845
          Length = 209

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SALTAYTPR 9
          SAL  YTP+
Sbjct: 36 SALEVYTPK 44
>NP_003944
          Length = 269

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SALTAYTPR 9
          SAL  YTP+
Sbjct: 36 SALEVYTPK 44
>NP_001139663
          Length = 119

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SALTAYTPR 9
          SAL  YTP+
Sbjct: 36 SALEVYTPK 44
>NP_001106853
          Length = 2093

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TAYTPR 9
           T+YTPR
Sbjct: 413 TSYTPR 418
>XP_006712889
          Length = 2069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TAYTPR 9
           T+YTPR
Sbjct: 430 TSYTPR 435
>NP_001180442
          Length = 501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ALTAYT 7
          ALTAYT
Sbjct: 59 ALTAYT 64
>NP_001180443
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ALTAYT 7
          ALTAYT
Sbjct: 59 ALTAYT 64
>NP_060434
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ALTAYT 7
          ALTAYT
Sbjct: 59 ALTAYT 64
>NP_001229695
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 24 TGYTPR 29
>NP_004737
          Length = 977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TAYTPR 9
           T YTPR
Sbjct: 326 TGYTPR 331
>NP_001003809
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 24 TGYTPR 29
>NP_001229693
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 32 TGYTPR 37
>NP_001229690
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TAYTPR 9
           T YTPR
Sbjct: 326 TGYTPR 331
>NP_001229692
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 38 TGYTPR 43
>NP_001229691
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 38 TGYTPR 43
>NP_853514
          Length = 1732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 310 LTALTPR 316
>NP_821158
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SALTAYTP 8
          SAL AY+P
Sbjct: 11 SALGAYSP 18
>NP_001229694
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 24 TGYTPR 29
>NP_005112
          Length = 2174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TAYTPR 9
           TAYTP+
Sbjct: 974 TAYTPQ 979
>NP_001180444
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ALTAYT 7
          ALTAYT
Sbjct: 30 ALTAYT 35
>NP_001167627
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           +T YTPR
Sbjct: 312 VTEYTPR 318
>XP_005258233
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 11 TGYTPR 16
>XP_005258232
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 32 TGYTPR 37
>XP_005258231
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 34 TGYTPR 39
>XP_006722430
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 70 TGYTPR 75
>XP_005258230
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TAYTPR 9
          T YTPR
Sbjct: 76 TGYTPR 81
>XP_005258229
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TAYTPR 9
           T YTPR
Sbjct: 326 TGYTPR 331
>XP_005258228
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TAYTPR 9
           T YTPR
Sbjct: 326 TGYTPR 331
>XP_005269598
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           +T YTPR
Sbjct: 312 VTEYTPR 318
>XP_006712109
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ALTAYT 7
          ALTAYT
Sbjct: 59 ALTAYT 64
>NP_001116512
          Length = 290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TAYTPR 9
           +AYTPR
Sbjct: 220 SAYTPR 225
>NP_940820
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 870 LTAETPR 876
>NP_001028776
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 835 LTAETPR 841
>NP_001028777
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 865 LTAETPR 871
>NP_055266
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 830 LTAETPR 836
>NP_001263309
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTAY P+
Sbjct: 489 LTAYKPK 495
>NP_057733
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTAY P+
Sbjct: 489 LTAYKPK 495
>NP_076425
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALTAYTP 8
           A TA+TP
Sbjct: 149 AFTAFTP 155
>NP_078978
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           L AY+PR
Sbjct: 641 LAAYSPR 647
>XP_005255569
          Length = 225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALTAYTP 8
           A TA+TP
Sbjct: 156 AFTAFTP 162
>XP_005255568
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALTAYTP 8
           A TA+TP
Sbjct: 179 AFTAFTP 185
>XP_006715751
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 779 LTAETPR 785
>XP_005249757
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 870 LTAETPR 876
>XP_006715750
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LTAYTPR 9
           LTA TPR
Sbjct: 870 LTAETPR 876
>XP_006713833
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ALTAYTPR 9
          ALT++ PR
Sbjct: 43 ALTSFLPR 50
>XP_006713832
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ALTAYTPR 9
          ALT++ PR
Sbjct: 14 ALTSFLPR 21
>XP_006713831
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ALTAYTPR 9
          ALT++ PR
Sbjct: 43 ALTSFLPR 50
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.118    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 608,349
Number of extensions: 951
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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