Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005350                                                              18    1935
NP_055892                                                              17    2528
NP_061985                                                              17    4312
NP_219489                                                              17    4312
XP_005260665                                                           17    4312
XP_006723948                                                           17    4312
XP_006722680                                                           17    4312
XP_006722679                                                           17    4312
NP_001276332                                                           16    5631
NP_001244947                                                           16    5631
NP_001276334                                                           16    5631
NP_758962                                                              16    5631
NP_001244946                                                           16    5631
NP_071757                                                              16    5631
NP_690863                                                              16    5631
XP_005253685                                                           16    5631
XP_005253684                                                           16    5631
XP_006718007                                                           16    5631
XP_005247955                                                           16    5631
XP_005247954                                                           16    5631
XP_005247953                                                           16    5631
XP_005247950                                                           16    5631
XP_005247951                                                           16    5631
XP_005247949                                                           16    5631
XP_005247948                                                           16    5631
NP_003950                                                              16    5631
NP_150279                                                              16    5631
NP_002199                                                              16    7355
NP_060170                                                              16    7355
NP_072047                                                              16    7355
NP_001276103                                                           16    7355
NP_001276105                                                           16    7355
NP_001276104                                                           16    7355
NP_001229658                                                           16    7355
NP_001018861                                                           16    7355
XP_005254448                                                           16    7355
XP_006720593                                                           16    7355
XP_005254446                                                           16    7355
NP_079023                                                              15    9605
NP_001025056                                                           15    9605
NP_006280                                                              15    9605
NP_001271175                                                           15    9605
NP_056371                                                              15    9605
NP_001271176                                                           15    9605
NP_001271174                                                           15    9605
NP_775885                                                              15    9605
NP_001004060                                                           15    9605
NP_001003681                                                           15    9605
NP_003239                                                              15    9605
NP_001004067                                                           15    9605
XP_006725258                                                           15    9605
XP_006724165                                                           15    9605
XP_006724164                                                           15    9605
XP_006724163                                                           15    9605
XP_005255375                                                           15    9605
XP_005267576                                                           15    9605
XP_006720175                                                           15    9605
XP_006720174                                                           15    9605
XP_005267573                                                           15    9605
XP_006720173                                                           15    9605
XP_006720172                                                           15    9605
XP_005267571                                                           15    9605
XP_006716915                                                           15    9605
XP_005251621                                                           15    9605
XP_005250117                                                           15    9605
XP_006712138                                                           15    9605
XP_005244859                                                           15    9605
XP_005244858                                                           15    9605
NP_003583                                                              15    9605
NP_055102                                                              15    9605
>NP_005350
          Length = 552

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           RALQLL EV
Sbjct: 531 RALQLLDEV 539
>NP_055892
          Length = 724

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RALQLLGE 8
           RAL+LLGE
Sbjct: 392 RALRLLGE 399
>NP_061985
          Length = 2146

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RALQLL E
Sbjct: 424 RALQLLAE 431
>NP_219489
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RALQLLGE 8
           +ALQLLG+
Sbjct: 308 KALQLLGD 315
>XP_005260665
          Length = 275

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RALQLLGE 8
           +ALQLLG+
Sbjct: 210 KALQLLGD 217
>XP_006723948
          Length = 367

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RALQLLGE 8
           +ALQLLG+
Sbjct: 302 KALQLLGD 309
>XP_006722680
          Length = 1636

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RALQLL E
Sbjct: 424 RALQLLAE 431
>XP_006722679
          Length = 2128

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RALQLL E
Sbjct: 424 RALQLLAE 431
>NP_001276332
          Length = 987

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLGEV 9
          RA+QLL +V
Sbjct: 67 RAIQLLSQV 75
>NP_001244947
          Length = 589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALQLLGEV 9
           A+QLLG+V
Sbjct: 247 AVQLLGDV 254
>NP_001276334
          Length = 1030

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLGEV 9
          RA+QLL +V
Sbjct: 67 RAIQLLSQV 75
>NP_758962
          Length = 589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALQLLGEV 9
           A+QLLG+V
Sbjct: 247 AVQLLGDV 254
>NP_001244946
          Length = 589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALQLLGEV 9
           A+QLLG+V
Sbjct: 247 AVQLLGDV 254
>NP_071757
          Length = 1030

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLGEV 9
          RA+QLL +V
Sbjct: 67 RAIQLLSQV 75
>NP_690863
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALQLLGEV 9
           A+QLLG+V
Sbjct: 225 AVQLLGDV 232
>XP_005253685
          Length = 1061

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RALQLLGEV 9
           RAL+L+G++
Sbjct: 724 RALELMGQL 732
>XP_005253684
          Length = 1073

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RALQLLGEV 9
           RAL+L+G++
Sbjct: 736 RALELMGQL 744
>XP_006718007
          Length = 1050

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLGEV 9
          RA+QLL +V
Sbjct: 88 RAIQLLSQV 96
>XP_005247955
          Length = 936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 504 RALNMLGE 511
>XP_005247954
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 592 RALNMLGE 599
>XP_005247953
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 682 RALNMLGE 689
>XP_005247950
          Length = 1115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 683 RALNMLGE 690
>XP_005247951
          Length = 1115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 683 RALNMLGE 690
>XP_005247949
          Length = 1115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 683 RALNMLGE 690
>XP_005247948
          Length = 1115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 683 RALNMLGE 690
>NP_003950
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RALQLLGEV 9
           RAL+L+G++
Sbjct: 731 RALELMGQL 739
>NP_150279
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 682 RALNMLGE 689
>NP_002199
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LQLLGEV 9
            LQ+LGE+
Sbjct: 1087 LQILGEI 1093
>NP_060170
          Length = 219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQLLGEV 9
           A+Q++GEV
Sbjct: 165 AMQVIGEV 172
>NP_072047
          Length = 723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R +QLLG++
Sbjct: 531 RTMQLLGQL 539
>NP_001276103
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R +QLLG++
Sbjct: 464 RTMQLLGQL 472
>NP_001276105
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R +QLLG++
Sbjct: 342 RTMQLLGQL 350
>NP_001276104
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R +QLLG++
Sbjct: 406 RTMQLLGQL 414
>NP_001229658
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQLLGEV 9
           A+Q++GEV
Sbjct: 165 AMQVIGEV 172
>NP_001018861
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LQLLGEV 9
           LQLLGE+
Sbjct: 569 LQLLGEM 575
>XP_005254448
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LQLLGEV 9
           LQLLGE+
Sbjct: 568 LQLLGEM 574
>XP_006720593
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LQLLGEV 9
           LQLLGE+
Sbjct: 569 LQLLGEM 575
>XP_005254446
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LQLLGEV 9
           LQLLGE+
Sbjct: 569 LQLLGEM 575
>NP_079023
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RALQLLGE 8
           RAL +LGE
Sbjct: 607 RALAVLGE 614
>NP_001025056
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RALQLLGE 8
           +A+Q+LGE
Sbjct: 182 QAVQMLGE 189
>NP_006280
          Length = 2541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    QLLGEV 9
            QLLGEV
Sbjct: 1104 QLLGEV 1109
>NP_001271175
          Length = 1782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>NP_056371
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>NP_001271176
          Length = 1803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>NP_001271174
          Length = 1783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>NP_775885
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R+LQL G+V
Sbjct: 532 RSLQLSGKV 540
>NP_001004060
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R+LQL G+V
Sbjct: 532 RSLQLSGKV 540
>NP_001003681
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 528 LQLLGE 533
>NP_003239
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QLLGEV 9
           QLLGEV
Sbjct: 232 QLLGEV 237
>NP_001004067
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R+LQL G+V
Sbjct: 532 RSLQLSGKV 540
>XP_006725258
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R+LQL G+V
Sbjct: 532 RSLQLSGKV 540
>XP_006724165
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 419 LQLLGE 424
>XP_006724164
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 571 LQLLGE 576
>XP_006724163
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 571 LQLLGE 576
>XP_005255375
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R+LQL G+V
Sbjct: 532 RSLQLSGKV 540
>XP_005267576
          Length = 1782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>XP_006720175
          Length = 1783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>XP_006720174
          Length = 1803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>XP_005267573
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>XP_006720173
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>XP_006720172
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>XP_005267571
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQLLGE 8
           LQLLGE
Sbjct: 642 LQLLGE 647
>XP_006716915
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    QLLGEV 9
            QLLGEV
Sbjct: 1104 QLLGEV 1109
>XP_005251621
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    QLLGEV 9
            QLLGEV
Sbjct: 1104 QLLGEV 1109
>XP_005250117
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QLLGEV 9
           QLLGEV
Sbjct: 729 QLLGEV 734
>XP_006712138
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQLLGEV 9
           +LQ+LGE+
Sbjct: 499 SLQILGEL 506
>XP_005244859
          Length = 151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RALQLLGE 8
           +A+Q+LGE
Sbjct: 119 QAVQMLGE 126
>XP_005244858
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RALQLLGE 8
           +A+Q+LGE
Sbjct: 182 QAVQMLGE 189
>NP_003583
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QLLGEV 9
           QLLGEV
Sbjct: 729 QLLGEV 734
>NP_055102
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLGEV 9
           R+LQL G+V
Sbjct: 532 RSLQLSGKV 540
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.145    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 438,324
Number of extensions: 607
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package