Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              19     665
NP_001120972                                                           19     665
XP_006716054                                                           19     665
XP_006716053                                                           19     665
XP_006716052                                                           19     665
XP_006716051                                                           19     665
NP_061028                                                              18    1482
NP_000598                                                              17    4312
NP_036588                                                              17    4312
NP_115896                                                              17    4312
NP_001171672                                                           17    4312
XP_006715291                                                           17    4312
NP_000599                                                              17    4312
NP_060947                                                              17    4312
NP_073744                                                              16    5631
NP_001030611                                                           16    5631
XP_005252192                                                           16    5631
NP_060365                                                              16    5631
NP_001265010                                                           16    5631
NP_000055                                                              16    7355
NP_001258665                                                           16    7355
NP_057141                                                              16    7355
NP_001258664                                                           16    7355
NP_005158                                                              16    7355
NP_003809                                                              16    7355
NP_683721                                                              16    7355
NP_001363                                                              16    7355
NP_001010891                                                           16    7355
NP_001161213                                                           16    7355
NP_004195                                                              16    7355
XP_006723723                                                           16    7355
XP_006721530                                                           16    7355
XP_006721529                                                           16    7355
XP_006721528                                                           16    7355
XP_005248552                                                           16    7355
NP_001077861                                                           15    9605
NP_001346                                                              15    9605
NP_958434                                                              15    9605
NP_004359                                                              15    9605
NP_001139729                                                           15    9605
NP_004739                                                              15    9605
NP_001191379                                                           15    9605
NP_065790                                                              15    9605
NP_001269328                                                           15    9605
NP_003846                                                              15    9605
NP_954854                                                              15    9605
NP_068777                                                              15    9605
XP_006725469                                                           15    9605
XP_006712886                                                           15    9605
XP_005264096                                                           15    9605
NP_004051                                                              15    9605
>NP_000236
          Length = 1390

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD ILSKYF
Sbjct: 823 LDGILSKYF 831
>NP_001120972
          Length = 1408

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD ILSKYF
Sbjct: 841 LDGILSKYF 849
>XP_006716054
          Length = 960

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD ILSKYF
Sbjct: 393 LDGILSKYF 401
>XP_006716053
          Length = 960

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD ILSKYF
Sbjct: 393 LDGILSKYF 401
>XP_006716052
          Length = 1409

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD ILSKYF
Sbjct: 842 LDGILSKYF 850
>XP_006716051
          Length = 1427

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD ILSKYF
Sbjct: 860 LDGILSKYF 868
>NP_061028
          Length = 632

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LDRILSKY 8
          LDR+LS+Y
Sbjct: 63 LDRVLSRY 70
>NP_000598
          Length = 201

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LDRILSKYF 9
          LDRI  K+F
Sbjct: 36 LDRITGKWF 44
>NP_036588
          Length = 90

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LDRILSKY 8
          LDR +SKY
Sbjct: 51 LDRCVSKY 58
>NP_115896
          Length = 809

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDRILSKY 8
           +D+I+SKY
Sbjct: 742 MDQIISKY 749
>NP_001171672
          Length = 809

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDRILSKY 8
           +D+I+SKY
Sbjct: 742 MDQIISKY 749
>XP_006715291
          Length = 558

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDRILSKY 8
           +D+I+SKY
Sbjct: 491 MDQIISKY 498
>NP_000599
          Length = 201

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LDRILSKYF 9
          LDRI  K+F
Sbjct: 36 LDRITGKWF 44
>NP_060947
          Length = 417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           L R+L KYF
Sbjct: 105 LTRVLFKYF 113
>NP_073744
          Length = 746

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRILSKY 8
           L+R+L KY
Sbjct: 473 LERVLKKY 480
>NP_001030611
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRILSKY 8
           L+R+L KY
Sbjct: 460 LERVLKKY 467
>XP_005252192
          Length = 735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRILSKY 8
           L+R+L KY
Sbjct: 462 LERVLKKY 469
>NP_060365
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRILSKYF 9
           DR+L +YF
Sbjct: 374 DRMLDEYF 381
>NP_001265010
          Length = 173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           +DRI SK+F
Sbjct: 97  VDRIPSKHF 105
>NP_000055
          Length = 1663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LDRILSKY 8
            +DR +SKY
Sbjct: 1425 VDRYISKY 1432
>NP_001258665
          Length = 185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  DRILSKYF 9
          DR+ +KY+
Sbjct: 32 DRLFAKYY 39
>NP_057141
          Length = 177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  DRILSKYF 9
          DR+ +KY+
Sbjct: 24 DRLFAKYY 31
>NP_001258664
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  DRILSKYF 9
          DR+ +KY+
Sbjct: 24 DRLFAKYY 31
>NP_005158
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRILSKY 8
           +DR+LS Y
Sbjct: 443 VDRVLSAY 450
>NP_003809
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RILSKY 8
           RILSKY
Sbjct: 160 RILSKY 165
>NP_683721
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD++L ++F
Sbjct: 340 LDQVLGRFF 348
>NP_001363
          Length = 4486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           LD++ S YF
Sbjct: 281 LDKLQSSYF 289
>NP_001010891
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DRILSKYF 9
           D ILS YF
Sbjct: 234 DDILSSYF 241
>NP_001161213
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DRILSKYF 9
           D ILS YF
Sbjct: 173 DDILSSYF 180
>NP_004195
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD++L ++F
Sbjct: 340 LDQVLGRFF 348
>XP_006723723
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RILSKY 8
           RILSKY
Sbjct: 160 RILSKY 165
>XP_006721530
          Length = 2746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           LD++ S YF
Sbjct: 281 LDKLQSSYF 289
>XP_006721529
          Length = 2817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           LD++ S YF
Sbjct: 281 LDKLQSSYF 289
>XP_006721528
          Length = 3869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           LD++ S YF
Sbjct: 281 LDKLQSSYF 289
>XP_005248552
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DRILSKYF 9
           D ILS YF
Sbjct: 234 DDILSSYF 241
>NP_001077861
          Length = 118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRILSKYF 9
           DRIL ++F
Sbjct: 94  DRILIRFF 101
>NP_001346
          Length = 118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRILSKYF 9
           DRIL ++F
Sbjct: 94  DRILIRFF 101
>NP_958434
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  DRILSKY 8
          +R+LSKY
Sbjct: 20 NRLLSKY 26
>NP_004359
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  DRILSKY 8
          +R+LSKY
Sbjct: 20 NRLLSKY 26
>NP_001139729
          Length = 143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LDRILSKY 8
           L+R LSKY
Sbjct: 125 LERQLSKY 132
>NP_004739
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD+ ++K+F
Sbjct: 677 LDQFINKFF 685
>NP_001191379
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD+ ++K+F
Sbjct: 677 LDQFINKFF 685
>NP_065790
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDRILSKYF 9
           LD+ ++K+F
Sbjct: 677 LDQFINKFF 685
>NP_001269328
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           L R+L K+F
Sbjct: 244 LPRVLEKHF 252
>NP_003846
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           L R+L K+F
Sbjct: 400 LPRVLEKHF 408
>NP_954854
          Length = 295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LDRILSK 7
          LDR LSK
Sbjct: 80 LDRFLSK 86
>NP_068777
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           +DRILS  F
Sbjct: 178 IDRILSAEF 186
>XP_006725469
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRILSKYF 9
           DRIL ++F
Sbjct: 185 DRILIRFF 192
>XP_006712886
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           L R+L K+F
Sbjct: 245 LPRVLEKHF 253
>XP_005264096
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDRILSKYF 9
           L R+L K+F
Sbjct: 399 LPRVLEKHF 407
>NP_004051
          Length = 295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LDRILSK 7
          LDR LSK
Sbjct: 80 LDRFLSK 86
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.157    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 445,831
Number of extensions: 693
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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