Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           18    1935
NP_001277143                                                           18    1935
NP_001319                                                              18    1935
NP_001012632                                                           18    1935
NP_001077383                                                           18    1935
NP_001320                                                              18    1935
NP_073713                                                              18    1935
XP_005269629                                                           18    1935
XP_005269628                                                           18    1935
XP_005269627                                                           18    1935
XP_005269626                                                           18    1935
XP_006717706                                                           18    1935
XP_005269625                                                           18    1935
XP_005269624                                                           18    1935
XP_006717705                                                           18    1935
XP_005269622                                                           18    1935
XP_005269621                                                           18    1935
XP_006717704                                                           18    1935
XP_005269619                                                           18    1935
XP_005269618                                                           18    1935
XP_005272320                                                           18    1935
XP_005272319                                                           18    1935
XP_005272318                                                           18    1935
NP_114160                                                              16    5631
XP_006724080                                                           16    5631
XP_005261054                                                           16    5631
XP_005261053                                                           16    5631
XP_005254003                                                           16    5631
XP_005254002                                                           16    5631
NP_066960                                                              16    5631
NP_658983                                                              16    5631
NP_849194                                                              16    7355
NP_803136                                                              16    7355
XP_005258593                                                           16    7355
XP_005246783                                                           16    7355
NP_065994                                                              16    7355
NP_060796                                                              15    9605
NP_660160                                                              15    9605
NP_001123620                                                           15    9605
NP_001123619                                                           15    9605
NP_695006                                                              15    9605
NP_056189                                                              15    9605
NP_001186509                                                           15    9605
NP_004696                                                              15    9605
NP_002855                                                              15    9605
NP_071418                                                              15    9605
NP_001186508                                                           15    9605
XP_005261558                                                           15    9605
XP_005261557                                                           15    9605
XP_005250075                                                           15    9605
XP_005250074                                                           15    9605
XP_005247756                                                           15    9605
XP_005247755                                                           15    9605
XP_005270805                                                           15    9605
NP_115734                                                              15    9605
NP_115514                                                              15    9605
NP_001123618                                                           15    9605
NP_690867                                                              15    9605
>NP_001277144
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>NP_001277143
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>NP_001319
          Length = 440

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 169 AARIRGETL 177
>NP_001012632
          Length = 429

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 158 AARIRGETL 166
>NP_001077383
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>NP_001320
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>NP_073713
          Length = 985

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 715 AARIRGETL 723
>XP_005269629
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269628
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269627
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269626
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_006717706
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269625
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269624
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_006717705
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269622
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269621
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_006717704
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269619
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005269618
          Length = 445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 175 AARIRGETL 183
>XP_005272320
          Length = 430

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 158 AARIRGETL 166
>XP_005272319
          Length = 430

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 158 AARIRGETL 166
>XP_005272318
          Length = 441

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           AARIR ETL
Sbjct: 169 AARIRGETL 177
>NP_114160
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ARIREETL 9
           ARI EETL
Sbjct: 247 ARIYEETL 254
>XP_006724080
          Length = 112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ARIREETL 9
          AR+REE L
Sbjct: 19 ARVREEIL 26
>XP_005261054
          Length = 246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ARIREETL 9
          AR+REE L
Sbjct: 19 ARVREEIL 26
>XP_005261053
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ARIREETL 9
          AR+REE L
Sbjct: 19 ARVREEIL 26
>XP_005254003
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ARIREETL 9
           ARI EETL
Sbjct: 248 ARIYEETL 255
>XP_005254002
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ARIREETL 9
           ARI EETL
Sbjct: 256 ARIYEETL 263
>NP_066960
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ARIREETL 9
           ARI EETL
Sbjct: 244 ARIYEETL 251
>NP_658983
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ARIREETL 9
          AR+REE L
Sbjct: 19 ARVREEIL 26
>NP_849194
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ARIREETL 9
           ARI EETL
Sbjct: 257 ARIFEETL 264
>NP_803136
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           A +IRE+TL
Sbjct: 275 ALQIREQTL 283
>XP_005258593
          Length = 652

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AARIREETL 9
           A +IRE+TL
Sbjct: 275 ALQIREQTL 283
>XP_005246783
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ARIREETL 9
           AR+++ETL
Sbjct: 601 ARLKDETL 608
>NP_065994
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ARIREETL 9
           AR+++ETL
Sbjct: 601 ARLKDETL 608
>NP_060796
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 253 ARIREE 258
>NP_660160
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  ARIREETL 9
          ++I+EETL
Sbjct: 85 SKIKEETL 92
>NP_001123620
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 343 ARIREE 348
>NP_001123619
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 343 ARIREE 348
>NP_695006
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AARIREET 8
           AARI EE+
Sbjct: 456 AARIEEES 463
>NP_056189
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AARIREE 7
           AARI+EE
Sbjct: 352 AARIQEE 358
>NP_001186509
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AARIREE 7
           AARI+EE
Sbjct: 352 AARIQEE 358
>NP_004696
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IREETL 9
           IREETL
Sbjct: 246 IREETL 251
>NP_002855
          Length = 1482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 320 ARIREE 325
>NP_071418
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIREETL 9
           R+RE+TL
Sbjct: 98  RLREDTL 104
>NP_001186508
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AARIREE 7
           AARI+EE
Sbjct: 373 AARIQEE 379
>XP_005261558
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AARIREE 7
           AARI+EE
Sbjct: 352 AARIQEE 358
>XP_005261557
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AARIREE 7
           AARI+EE
Sbjct: 387 AARIQEE 393
>XP_005250075
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 114 ARIREE 119
>XP_005250074
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 267 ARIREE 272
>XP_005247756
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIREETL 9
           R+RE+TL
Sbjct: 98  RLREDTL 104
>XP_005247755
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIREETL 9
           R+RE+TL
Sbjct: 98  RLREDTL 104
>XP_005270805
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AARIREET 8
           AARI EE+
Sbjct: 456 AARIEEES 463
>NP_115734
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 375 ARIREE 380
>NP_115514
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IREETL 9
           IREETL
Sbjct: 209 IREETL 214
>NP_001123618
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ARIREE 7
           ARIREE
Sbjct: 343 ARIREE 348
>NP_690867
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IREETL 9
           IREETL
Sbjct: 209 IREETL 214
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.127    0.301 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 454,542
Number of extensions: 523
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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