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Details of CancerPDF entry with Sequence TVGSLAGQPLQERAQAWGERL
Primary information
sequence IDSeq_8662
Peptide sequenceTVGSLAGQPLQERAQAWGERL
CancerPDF_ID CancerPDF_ID85, CancerPDF_ID1083, CancerPDF_ID1695, CancerPDF_ID9585,
PMID16896061,16395409,21136997,21533267
Protein NameApolipoprotein E,Apolipoprotein E,Apolipoprotein E,Apolipoprotein E
UniprotKB Entry NameAPOE_HUMAN,APOE_HUMAN,APOE_HUMAN,APOE_HUMAN
FluidSerum,Serum,Serum,Serum
M/Z2267.07,2267.07,2266.18183,756.38
Charge1,1,1,3
Mass (in Da)2267.18,NA,NA,NA
fdrNA,NA,NA,NA
Profiling TechniqueMALDI-TOF,MALDI-TOF,LC-MS,LC-MS
Peptide Identification techniqueQ/TOF MS/MS,Q/TOF/TOF and LC-MS/MS,LC-MS-MS/MS,LC/MS/MS
Quantification TechniqueNA,NA,LC-ESI-MS,Multiple Reaction Monitoring
Labelled/Label FreeLabel Free,Label Free,Label Free,Label Free
FDRNA,less than 1 “5,NA,1.49
CancerPDF_ID CancerPDF_ID85, CancerPDF_ID1083, CancerPDF_ID1695, CancerPDF_ID9585,
p-Value1.00E-05,NA,NA,less than 0.01
SoftwareMASCOT,MASCOT (v 2.0.04 for Windows),MASCOT(v. 2.2.01),MASCOT
Length21,21,21,21
Cancer TypeMetastatic thyroid carcinomas,"Advanced Prostate, Breast and Bladder cancer",Colorectal cancer,Lung adenocarcinoma
DatabaseNCBI refseq Protein Database,NCBI refseq Protein Database,SwissProt Database,Swissprot Database (57.4)
ModificationNA,NA,NA,NA
Number of Patients40 metastatic thyroid carcinoma patients and 40 normal for training phase and 10 metastatic thyroid carcinoma and 10 normal individuals for independent validation,"Advanced prostate (n = 32), breast (n = 21), and bladder (n = 20) cancer, 33 healthy in training test set, In validation set 41 independent serum samples from patients with advanced prostate cancer (prostate 2 [PR2])",30 patients and 30 healthy controls,62 lung adenocarcinoma and 30 healthy control
RegulationNA,NA,NA,Differentially expressed between Lung cancer vs control
ValidationIndependent validation,Independent validation,Leave One out Cross validation,MRM-based validation of 19 candidates
Sensitivity95% on independent dataset,97.5% on independent validation dataset,NA,NA
Specificity95% on independent dataset,NA,NA,NA
AccuracyNA,97.5 % on validation dataset,NA,0.7
Peptide AtlasNA
IEDB