| Primary information |
|---|
| sequence ID | Seq_4548 |
| Peptide sequence | LAEGGGVR |
| CancerPDF_ID | CancerPDF_ID1, CancerPDF_ID1019, CancerPDF_ID1206, CancerPDF_ID10737, |
| PMID | 16896061,16395409,21136997,21805675 |
| Protein Name | Fibrinogen alpha chain,Fibrinopeptide A,Fibrinogen alpha,Fibrinogen alpha chain |
| UniprotKB Entry Name | FIBA_HUMAN,FIBA_HUMAN,FIBA_HUMAN,FIBA_HUMAN |
| Fluid | Serum,Serum,Serum,Urine |
| M/Z | 758.45,758.45,757.40825,758.4169 |
| Charge | 1,1,1,NA |
| Mass (in Da) | 758.41,NA,NA,NA |
| fdr | NA,NA,NA,NA |
| Profiling Technique | MALDI-TOF,MALDI-TOF,LC-MS,MALDI-TOF |
| Peptide Identification technique | Q/TOF MS/MS,Q/TOF/TOF and LC-MS/MS,LC-MS-MS/MS,MALDI-TOF-MS |
| Quantification Technique | NA,NA,LC-ESI-MS,NA |
| Labelled/Label Free | Label Free,Label Free,Label Free,Label Free |
| FDR | NA,less than 1 “5,NA,1 |
| CancerPDF_ID | CancerPDF_ID1, CancerPDF_ID1019, CancerPDF_ID1206, CancerPDF_ID10737, |
| p-Value | 1.00E-05,1.25E-08,NA,NA |
| Software | MASCOT,MASCOT (v 2.0.04 for Windows),MASCOT(v. 2.2.01),NA |
| Length | 8,8,8,8 |
| Cancer Type | Metastatic thyroid carcinomas,"Advanced Prostate, Breast and Bladder cancer",Colorectal cancer,Muscle-invasive bladder cancer |
| Database | NCBI refseq Protein Database,NCBI refseq Protein Database,SwissProt Database,SwissProt Database |
| Modification | NA,NA,NA,NA |
| Number of Patients | 40 metastatic thyroid carcinoma patients and 40 normal for training phase and 10 metastatic thyroid carcinoma and 10 normal individuals for independent validation,"Advanced prostate (n = 32), breast (n = 21), and bladder (n = 20) cancer, 33 healthy",30 patients and 30 healthy controls,751 bladder cancer and 127 control |
| Regulation | NA,"Downregulated in cancer vs normal with Ratio of median intensity (patients/Controls) = 0.66, 0.95 and 0.65 in prostate, bladder and breast cancer respectively",NA,Differentially expressed between cancer vs normal samples |
| Validation | Independent validation,Independent validation,Leave One out Cross validation,Mann-Whitney tests and areas under receiver-operator characteristic |
| Sensitivity | 95% on independent dataset,97.5% for multiclass and 100 % for binary classification system on independent validation dataset,89.80%,NA |
| Specificity | 95% on independent dataset,NA,94.60%,NA |
| Accuracy | NA,97.5 % on validation dataset,NA,NA |
| Peptide Atlas | NA |
| IEDB | 462581
|