Browse result page of B3Pdb

The total number entries retrieved from this search are 137, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0003K16ApoENANANANANA16NACationicChemically synthesizedNAhCMEC/D3 monolayersNALaser confocal microscopyThe uptake of AF647-K16ApoE-targeted nanoparticles was substantially greater than the AF647-targetedWT mice75 μg/μLNAInjected into the femoral vein of 2- year-old APP transgenic (Tg2576) miceThe K16ApoE-targeted nanoparticles showed 8- to 10-fold higher accumulation in various brain regions It enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain. Transcytosis intracellular It is given in the combination with IgG4.1 Alzheimer’s disease NA NA NA 30300748
b3pdb_0041OdorranalectinYASPKSFRYPNGVLACTTyrAlaSerProLysSerPheArgTyrProAsnGlyValLeuAlaCysThrNANAConjugated with 5(6)-carboxyfluorescein at N-termi17LinearNAfrogN[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)OhCMEC/D3 cells2500 cells per cm squareLC/MS and Fluorescence microscopyIt shows the cellulr uptake of OL at the BBB endothelium.NANANANANA TAT-Modified MVIIA for Crossing the Blood-Brain Barrier Receptor-mediated transcytosis NA Alone NA NA NA NA 31068126
b3pdb_0056APep2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrFAM is conjgated at the N-terminalNANA19LinearNAChemically synthesizedN[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0057PPII(R8X)VRLPPPVXLPPPVRLPPPValArgLeuProProProValXaaLeuProProProValArgLeuProProProCuAAC conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0058PPII(R8K)VRLPPPVKLPPPVRLPPPValArgLeuProProProValLysLeuProProProValArgLeuProProProAmide conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0059PPII(L3X)VRXPPPVRLPPPVRLPPPValArgXaaProProProValArgLeuProProProValArgLeuProProProCuAAC conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0060PPII(L15X)VRLPPPVRLPPPVRXPPPValArgLeuProProProValArgLeuProProProValArgXaaProProProCuACC conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0061PPII(L3X;L15X)VRXPPPVRLPPPVRXPPPValArgXaaProProProValArgLeuProProProValArgXaaProProProCuAAC conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0062PPII(L3X;V13X)VRXPPPVRLPPPXRLPPPValArgXaaProProProValArgLeuProProProXaaArgLeuProProProCuAAC conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0063PPII(L3X;L15K)VRXPPPVRLPPPVRKPPPValArgXaaProProProValArgLeuProProProValArgLysProProProAmide and CuAAC conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0064PPII(L3X;V13K)VRXPPPVRLPPPKRLPPPValArgXaaProProProValArgLeuProProProLysArgLeuProProProAmide and CuAAC conjugated at N-terminusNANA18LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0065Ang-2CTFFYGGSRGKRNNFKTEECysThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluNANANA19LinearNAChemically synthesizedN[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)ONANANANAC57BL6 mice1 mg/mLIntraperitonealFluorescent microscopyLocalization of the nanoparticle within the brain cells, highlighting in particular the neuron accum Brain-targeted PLGA nanoparticles were able to cross the BBB and accumulated in neuronal cells, thus Transcytosis NA Conjugated to poly(lactic-co-glycolic acid) (PLGA) NA NA NA NA 31963430
b3pdb_0153ApominCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18LinearNAChemically synthesizedNACaco-2 cell line200 microliter of peptideBBB-RTU cell kit assay PAMPA methodThe difference in peptide concentration between donor and acceptor cell was below 1%, indicate cellsNANANANANA NA NA NA NA CNS NA NA NA 24281722
b3pdb_0154ApominCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18CyclicNAChemically synthesizedNACaco-2 cell line200 microliter of peptideBBB-RTU cell kit assay PAMPA method1.7+/- 0.1 apparent permeabilityNANANANANA NA NA NA NA CNS NA NA NA 24281722
b3pdb_0155ApooCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18CyclicNAChemically synthesizedNACaco-2 cell line200 microliter of peptideBBB-RTU cell kit assay PAMPA method1.6+/- 0.2 apparent permeabilityNANANANANA NA NA NA NA CNS NA NA NA 24281722
b3pdb_0156ApooCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18CyclicNAChemically synthesizedNACaco-2 cell line100 microliter of peptideBBB-RTU cell kit assay PAMPA method2.3+/- 0.7 apparent permeabilityNANANANANA NA NA NA NA CNS NA NA NA 24281722
b3pdb_0157ApominCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18CyclicNAChemically synthesizedNACaco-2 cell line200 microliter of peptideBBB-RTU cell kit assay PAMPA method1.8+/- 0.1 apparent permeabilityNANANANANA NA NA NA NA CNS NA NA NA 24281722
b3pdb_0158ApooCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18CyclicNAChemically synthesizedNACaco-2 cell line200 microliter of peptideBBB-RTU cell kit assay PAMPA method1.7+/- 0.2 apparent permeabilityNANANANANA NA NA NA NA CNS NA NA NA 24281722
b3pdb_0159ApooCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18CyclicNAChemically synthesizedNACaco-2 cell line100 microliter of peptideBBB-RTU cell kit assay PAMPA method2.5+/- 0.8 apparent permeabilityNANANANANA NA NA NA NA CNS NA NA NA 24281722
b3pdb_0163ASA-APOEIILRKLRKRLLLRKLRKRLLLeuArgLysLeuArgLysArgLeuLeuLeuArgLysLeuArgLysArgLeuLeuConjugated with ASA drugNANA18LinearNANANACHO cell line2.5 microgram/ mlcellular uptake assay32 % cellular uptakeNANANANANA NA Transendocytosis NA NA Lysosomal disorder NA NA NA 24573272
b3pdb_0164APO-Ang2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrConjugated with ASA drugNANA19LinearNANANACHO cell line2.5 microgram/ mlcellular uptake assay13 % cellular uptakeNANANANANA NA Transendocytosis NA NA Lysosomal disorder NA NA NA 24573272
b3pdb_0168ASA-APOEIILRKLRKRLLLRKLRKRLLLeuArgLysLeuArgLysArgLeuLeuLeuArgLysLeuArgLysArgLeuLeuConjugated with ASA drugNANA18LinearNANANAbEND cell line2.5 microgram/ mlcellular uptake assay19.3 % cellular uptakeNANANANANA NA Transendocytosis NA NA Lysosomal disorder NA NA NA 24573272
b3pdb_0169APO-Ang2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrConjugated with ASA drugNANA19LinearNANANAbEND cell line2.5 microgram/ mlcellular uptake assay22.9 % cellular uptakeNANANANANA NA Transendocytosis NA NA Lysosomal disorder NA NA NA 24573272
b3pdb_0173ASA-APOEIILRKLRKRLLLRKLRKRLLLeuArgLysLeuArgLysArgLeuLeuLeuArgLysLeuArgLysArgLeuLeuConjugated with ASA drugNANA18LinearNANANAPBCECs cell line0.02% cells were addedBasolateral screening assay150% transferNANANANANA NA Basolateral NA NA Lysosomal disorder NA NA NA 24573272
b3pdb_0174APO-Ang2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrConjugated with ASA drugNANA19LinearNANANAPBCECs cell line0.02% cells were addedBasolateral screening assay120% transferNANANANANA NA Basolateral NA NA Lysosomal disorder NA NA NA 24573272
b3pdb_0175Angiopep-2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrNANAConjugated with Tratuzumab19LinearNANANANANANANAMale Crl:Cd-1 nude mice10mg/KgIntravenous Fluoroscent screening by FITC labbled peptide maass in brain tissueSignificant fluoroscdnt observed in brain tissue NA NA NA NA Breast cancer metastasis NA NA NA 25492620
b3pdb_0176Angiopep-2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrNANAConjugated with Tratuzumab19LinearNANANANANANANAMale mice xenograft for BT 474 cell line intracerebrally6 ml/kgIntravenous In situ brain perfusion assay10 time increase of Mab as compared to control in brain tissue NA NA NA NA Breast cancer metastasis NA NA NA 25492620
b3pdb_0199Bacteriophage deriveDPQILMGVLRSIRGFGVKLAspProGlnIleLeuMetGlyValLeuArgSerIleArgGlyPheGlyValLysLeuNANANA19LinearNAT7 Bacteiophage derivedNANANANANAMale wistar miceNANANANA Can cross BBB as well as Blood CSF barrier Transendocytosis NA NA Alzheimer NA NA NA 26411801
b3pdb_0215Bacteriophage deriveLYVLHSRGLWGFKLAAALELeuTyrValLeuHisSerArgGlyLeuTrpGlyPheLysLeuAlaAlaAlaLeuGluNANANA19LinearNAT7 Bacteiophage derivedNANANANANAMale wistar miceNANANANA Can cross BBB as well as Blood CSF barrier Transendocytosis NA NA Alzheimer NA NA NA 26411801
b3pdb_0381ApaminCNCKAPETALCARRCQQHCysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHisNANANA18LinearNANANANANANANANANANANANA NA NA NA NA NA NA NA NA 24281722
b3pdb_0394Angiopep-2 (AP2)TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrNANANA19LinearNANAbEnd.3NANAmouseNANANANANANA NA NA NA NA NA NA NA NA 24769213
b3pdb_0449Melanin-concentratinDFDMLRCMLGRVYRPCWQVAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-ValNANACys7-Cys1619LinearNANA[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=ONANANANANANANANANA NA NA NA NA NA NA NA NA NA
b3pdb_0468Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.000052 mL/(g x min) Direct iodination 10617143
b3pdb_0469Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAIntravenous NANA NA Permeability NA NA NA Initial distribution volume 0.0153 ml/g Direct iodination 10617143
b3pdb_0470Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Initial distribution vaolume 0.00137 ml/g Direct iodination 10617143
b3pdb_0471Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Unidirectional flux rate constant 0.000594 mL/(g x min) Direct iodination 10617143
b3pdb_0472Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 20% Direct iodination 10617143
b3pdb_0473Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 80% Direct iodination 10617143
b3pdb_0474Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAHPLCNANANANANANA NA NA NA NA NA % injected dose 53.3 %/g Direct iodination 10617143
b3pdb_0475Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAHPLCNANANANANANA NA NA NA NA NA % injected dose 78.7 %/g Direct iodination 10617143
b3pdb_0476Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAHPLCNANANANANANA NA NA NA NA NA % injected dose 83.3 %/g Direct iodination 10617143
b3pdb_0477Phe13,Tyr19-Melanin DFDMLRCMLGRVFRPCWQYAsp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-TyrNANACys7-Cys1619LinearNAmouse,rat[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=ONANAShake FlaskNANANANANANA NA NA NA NA NA Log P -1.04 Direct iodination 10617143
b3pdb_0804Api88Guan-ONNRPVYIPRPRPPHPRL-NH2Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2NANANA18LinearNAChemically synthesizedNANANAEfflux study ICUNANANANANANA NA Permeability NA NA NA half life, brain 11.36 min Direct iodination 22594381
b3pdb_0805Api88Guan-ONNRPVYIPRPRPPHPRL-NH2Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2NANANA18LinearNAChemically synthesizedNANANAEfflux study ICUNANANANANANA NA Permeability NA NA NA Brain elemination rate constant 0.061 min-1 Direct iodination 22594381
b3pdb_0806Api88Guan-ONNRPVYIPRPRPPHPRL-NH2Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2NANANA18LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 22.50% Direct iodination 22594381
b3pdb_0807Api88Guan-ONNRPVYIPRPRPPHPRL-NH2Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2NANANA18LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 77.50% Direct iodination 22594381
b3pdb_0808Api88Guan-ONNRPVYIPRPRPPHPRL-NH2Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2NANANA18LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.00037 mL/(g x min) Direct iodination 22594381
b3pdb_0809Api88Guan-ONNRPVYIPRPRPPHPRL-NH2Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2NANANA18LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Initial disrobution volume 0.02606 ml/g Direct iodination 22594381
b3pdb_0810Apidaecin Api137Guan-ONNRPVYIPRPRPPHPRLGuan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-LeuNANANA18LinearNAChemically synthesizedNANANAEfflux study ICUNANANANANANA NA Permeability NA NA NA Brain elemination rate constant -0.022 min-1 Direct iodination 24164260
b3pdb_0811Apidaecin Api137Guan-ONNRPVYIPRPRPPHPRLGuan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-LeuNANANA18LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 23% Direct iodination 24164260