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Browse result page of B3Pdb
The total number entries retrieved from this search are
137
, scroll left/right for detailed information.
B3pdbID
PEPTIDE NAME
PEPTIDE SEQUENCE (1-letter)
PEPTIDE SEQUENCE (3-letter)
N-TERMINAL MODIFICATION
C-TERMINAL MODIFICATION
CHEMICAL MODIFICATION
PEPTIDE LENGTH
PEPTIDE CONFORMATION
PEPTIDE NATURE
SOURCE/ORIGIN OF PEPTIDE
SMILES
CELL LINE
In vitro
CONCENTRATION
In vitro
METHOD
In vitro
RESULT
ANIMAL MODEL
In vivo
CONCENTRATION
In vivo
MODE OF DELIVERY
In vivo
METHOD
In vivo
RESULT
ACTION
TRANSPORT TYPE
SUBCELLULAR LOCALISATION
COMBINATION
PHYSICAL CONDITION
RESPONSE
RESULT
LABEL
PMID
b3pdb_0003
K16ApoE
NA
NA
NA
NA
NA
16
NA
Cationic
Chemically synthesized
NA
hCMEC/D3 monolayers
NA
Laser confocal microscopy
The uptake of AF647-K16ApoE-targeted nanoparticles was substantially greater than the AF647-targeted
WT mice
75 μg/μL
NA
Injected into the femoral vein of 2- year-old APP transgenic (Tg2576) mice
The K16ApoE-targeted nanoparticles showed 8- to 10-fold higher accumulation in various brain regions
It enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain.
Transcytosis
intracellular
It is given in the combination with IgG4.1
Alzheimer’s disease
NA
NA
NA
30300748
b3pdb_0041
Odorranalectin
YASPKSFRYPNGVLACT
TyrAlaSerProLysSerPheArgTyrProAsnGlyValLeuAlaCysThr
NA
NA
Conjugated with 5(6)-carboxyfluorescein at N-termi
17
Linear
NA
frog
N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O
hCMEC/D3 cells
2500 cells per cm square
LC/MS and Fluorescence microscopy
It shows the cellulr uptake of OL at the BBB endothelium.
NA
NA
NA
NA
NA
TAT-Modified MVIIA for Crossing the Blood-Brain Barrier
Receptor-mediated transcytosis
NA
Alone
NA
NA
NA
NA
31068126
b3pdb_0056
APep2
TFFYGGSRGKRNNFKTEEY
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
FAM is conjgated at the N-terminal
NA
NA
19
Linear
NA
Chemically synthesized
N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0057
PPII(R8X)
VRLPPPVXLPPPVRLPPP
ValArgLeuProProProValXaaLeuProProProValArgLeuProProPro
CuAAC conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0058
PPII(R8K)
VRLPPPVKLPPPVRLPPP
ValArgLeuProProProValLysLeuProProProValArgLeuProProPro
Amide conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0059
PPII(L3X)
VRXPPPVRLPPPVRLPPP
ValArgXaaProProProValArgLeuProProProValArgLeuProProPro
CuAAC conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0060
PPII(L15X)
VRLPPPVRLPPPVRXPPP
ValArgLeuProProProValArgLeuProProProValArgXaaProProPro
CuACC conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0061
PPII(L3X;L15X)
VRXPPPVRLPPPVRXPPP
ValArgXaaProProProValArgLeuProProProValArgXaaProProPro
CuAAC conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0062
PPII(L3X;V13X)
VRXPPPVRLPPPXRLPPP
ValArgXaaProProProValArgLeuProProProXaaArgLeuProProPro
CuAAC conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0063
PPII(L3X;L15K)
VRXPPPVRLPPPVRKPPP
ValArgXaaProProProValArgLeuProProProValArgLysProProPro
Amide and CuAAC conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0064
PPII(L3X;V13K)
VRXPPPVRLPPPKRLPPP
ValArgXaaProProProValArgLeuProProProLysArgLeuProProPro
Amide and CuAAC conjugated at N-terminus
NA
NA
18
Linear
NA
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0065
Ang-2
CTFFYGGSRGKRNNFKTEE
CysThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGlu
NA
NA
NA
19
Linear
NA
Chemically synthesized
N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O
NA
NA
NA
NA
C57BL6 mice
1 mg/mL
Intraperitoneal
Fluorescent microscopy
Localization of the nanoparticle within the brain cells, highlighting in particular the neuron accum
Brain-targeted PLGA nanoparticles were able to cross the BBB and accumulated in neuronal cells, thus
Transcytosis
NA
Conjugated to poly(lactic-co-glycolic acid) (PLGA)
NA
NA
NA
NA
31963430
b3pdb_0153
Apomin
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
Caco-2 cell line
200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
The difference in peptide concentration between donor and acceptor cell was below 1%, indicate cells
NA
NA
NA
NA
NA
NA
NA
NA
NA
CNS
NA
NA
NA
24281722
b3pdb_0154
Apomin
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Cyclic
NA
Chemically synthesized
NA
Caco-2 cell line
200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.7+/- 0.1 apparent permeability
NA
NA
NA
NA
NA
NA
NA
NA
NA
CNS
NA
NA
NA
24281722
b3pdb_0155
Apoo
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Cyclic
NA
Chemically synthesized
NA
Caco-2 cell line
200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.6+/- 0.2 apparent permeability
NA
NA
NA
NA
NA
NA
NA
NA
NA
CNS
NA
NA
NA
24281722
b3pdb_0156
Apoo
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Cyclic
NA
Chemically synthesized
NA
Caco-2 cell line
100 microliter of peptide
BBB-RTU cell kit assay PAMPA method
2.3+/- 0.7 apparent permeability
NA
NA
NA
NA
NA
NA
NA
NA
NA
CNS
NA
NA
NA
24281722
b3pdb_0157
Apomin
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Cyclic
NA
Chemically synthesized
NA
Caco-2 cell line
200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.8+/- 0.1 apparent permeability
NA
NA
NA
NA
NA
NA
NA
NA
NA
CNS
NA
NA
NA
24281722
b3pdb_0158
Apoo
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Cyclic
NA
Chemically synthesized
NA
Caco-2 cell line
200 microliter of peptide
BBB-RTU cell kit assay PAMPA method
1.7+/- 0.2 apparent permeability
NA
NA
NA
NA
NA
NA
NA
NA
NA
CNS
NA
NA
NA
24281722
b3pdb_0159
Apoo
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Cyclic
NA
Chemically synthesized
NA
Caco-2 cell line
100 microliter of peptide
BBB-RTU cell kit assay PAMPA method
2.5+/- 0.8 apparent permeability
NA
NA
NA
NA
NA
NA
NA
NA
NA
CNS
NA
NA
NA
24281722
b3pdb_0163
ASA-APOEII
LRKLRKRLLLRKLRKRLL
LeuArgLysLeuArgLysArgLeuLeuLeuArgLysLeuArgLysArgLeuLeu
Conjugated with ASA drug
NA
NA
18
Linear
NA
NA
NA
CHO cell line
2.5 microgram/ ml
cellular uptake assay
32 % cellular uptake
NA
NA
NA
NA
NA
NA
Transendocytosis
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0164
APO-Ang2
TFFYGGSRGKRNNFKTEEY
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
Conjugated with ASA drug
NA
NA
19
Linear
NA
NA
NA
CHO cell line
2.5 microgram/ ml
cellular uptake assay
13 % cellular uptake
NA
NA
NA
NA
NA
NA
Transendocytosis
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0168
ASA-APOEII
LRKLRKRLLLRKLRKRLL
LeuArgLysLeuArgLysArgLeuLeuLeuArgLysLeuArgLysArgLeuLeu
Conjugated with ASA drug
NA
NA
18
Linear
NA
NA
NA
bEND cell line
2.5 microgram/ ml
cellular uptake assay
19.3 % cellular uptake
NA
NA
NA
NA
NA
NA
Transendocytosis
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0169
APO-Ang2
TFFYGGSRGKRNNFKTEEY
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
Conjugated with ASA drug
NA
NA
19
Linear
NA
NA
NA
bEND cell line
2.5 microgram/ ml
cellular uptake assay
22.9 % cellular uptake
NA
NA
NA
NA
NA
NA
Transendocytosis
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0173
ASA-APOEII
LRKLRKRLLLRKLRKRLL
LeuArgLysLeuArgLysArgLeuLeuLeuArgLysLeuArgLysArgLeuLeu
Conjugated with ASA drug
NA
NA
18
Linear
NA
NA
NA
PBCECs cell line
0.02% cells were added
Basolateral screening assay
150% transfer
NA
NA
NA
NA
NA
NA
Basolateral
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0174
APO-Ang2
TFFYGGSRGKRNNFKTEEY
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
Conjugated with ASA drug
NA
NA
19
Linear
NA
NA
NA
PBCECs cell line
0.02% cells were added
Basolateral screening assay
120% transfer
NA
NA
NA
NA
NA
NA
Basolateral
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0175
Angiopep-2
TFFYGGSRGKRNNFKTEEY
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
NA
NA
Conjugated with Tratuzumab
19
Linear
NA
NA
NA
NA
NA
NA
NA
Male Crl:Cd-1 nude mice
10mg/Kg
Intravenous
Fluoroscent screening by FITC labbled peptide maass in brain tissue
Significant fluoroscdnt observed in brain tissue
NA
NA
NA
NA
Breast cancer metastasis
NA
NA
NA
25492620
b3pdb_0176
Angiopep-2
TFFYGGSRGKRNNFKTEEY
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
NA
NA
Conjugated with Tratuzumab
19
Linear
NA
NA
NA
NA
NA
NA
NA
Male mice xenograft for BT 474 cell line intracerebrally
6 ml/kg
Intravenous
In situ brain perfusion assay
10 time increase of Mab as compared to control in brain tissue
NA
NA
NA
NA
Breast cancer metastasis
NA
NA
NA
25492620
b3pdb_0199
Bacteriophage derive
DPQILMGVLRSIRGFGVKL
AspProGlnIleLeuMetGlyValLeuArgSerIleArgGlyPheGlyValLysLeu
NA
NA
NA
19
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0215
Bacteriophage derive
LYVLHSRGLWGFKLAAALE
LeuTyrValLeuHisSerArgGlyLeuTrpGlyPheLysLeuAlaAlaAlaLeuGlu
NA
NA
NA
19
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0381
Apamin
CNCKAPETALCARRCQQH
CysAsnCysLysAlaProGluThrAlaLeuCysAlaArgArgCysGlnGlnHis
NA
NA
NA
18
Linear
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
24281722
b3pdb_0394
Angiopep-2 (AP2)
TFFYGGSRGKRNNFKTEEY
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
NA
NA
NA
19
Linear
NA
NA
bEnd.3
NA
NA
mouse
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
24769213
b3pdb_0449
Melanin-concentratin
DFDMLRCMLGRVYRPCWQV
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val
NA
NA
Cys7-Cys16
19
Linear
NA
NA
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
b3pdb_0468
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
Unidirectional influx rate constant
0.000052 mL/(g x min)
Direct iodination
10617143
b3pdb_0469
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
Initial distribution volume
0.0153 ml/g
Direct iodination
10617143
b3pdb_0470
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
NA
NA
NA
NA
in situ brain perfusion
NA
NA
NA
Permeability
NA
NA
NA
Initial distribution vaolume
0.00137 ml/g
Direct iodination
10617143
b3pdb_0471
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
NA
NA
NA
NA
in situ brain perfusion
NA
NA
NA
Permeability
NA
NA
NA
Unidirectional flux rate constant
0.000594 mL/(g x min)
Direct iodination
10617143
b3pdb_0472
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
Capillary depletion
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% capillary
20%
Direct iodination
10617143
b3pdb_0473
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
Capillary depletion
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% parenchyma
80%
Direct iodination
10617143
b3pdb_0474
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
HPLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% injected dose
53.3 %/g
Direct iodination
10617143
b3pdb_0475
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
HPLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% injected dose
78.7 %/g
Direct iodination
10617143
b3pdb_0476
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
HPLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% injected dose
83.3 %/g
Direct iodination
10617143
b3pdb_0477
Phe13,Tyr19-Melanin
DFDMLRCMLGRVFRPCWQY
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
NA
NA
Cys7-Cys16
19
Linear
NA
mouse,rat
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
NA
NA
Shake Flask
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Log P
-1.04
Direct iodination
10617143
b3pdb_0804
Api88
Guan-ONNRPVYIPRPRPPHPRL-NH2
Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
Efflux study ICU
NA
NA
NA
NA
NA
NA
NA
Permeability
NA
NA
NA
half life, brain
11.36 min
Direct iodination
22594381
b3pdb_0805
Api88
Guan-ONNRPVYIPRPRPPHPRL-NH2
Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
Efflux study ICU
NA
NA
NA
NA
NA
NA
NA
Permeability
NA
NA
NA
Brain elemination rate constant
0.061 min-1
Direct iodination
22594381
b3pdb_0806
Api88
Guan-ONNRPVYIPRPRPPHPRL-NH2
Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
Capillary depletion
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% capillary
22.50%
Direct iodination
22594381
b3pdb_0807
Api88
Guan-ONNRPVYIPRPRPPHPRL-NH2
Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
Capillary depletion
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% parenchyma
77.50%
Direct iodination
22594381
b3pdb_0808
Api88
Guan-ONNRPVYIPRPRPPHPRL-NH2
Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
Unidirectional influx rate constant
0.00037 mL/(g x min)
Direct iodination
22594381
b3pdb_0809
Api88
Guan-ONNRPVYIPRPRPPHPRL-NH2
Guan-Orn-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-NH2
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
Initial disrobution volume
0.02606 ml/g
Direct iodination
22594381
b3pdb_0810
Apidaecin Api137
Guan-ONNRPVYIPRPRPPHPRL
Guan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
Efflux study ICU
NA
NA
NA
NA
NA
NA
NA
Permeability
NA
NA
NA
Brain elemination rate constant
-0.022 min-1
Direct iodination
24164260
b3pdb_0811
Apidaecin Api137
Guan-ONNRPVYIPRPRPPHPRL
Guan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu
NA
NA
NA
18
Linear
NA
Chemically synthesized
NA
NA
NA
Capillary depletion
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% capillary
23%
Direct iodination
24164260
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