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Browse result page of B3Pdb
The total number entries retrieved from this search are
92
, scroll left/right for detailed information.
B3pdbID
PEPTIDE NAME
PEPTIDE SEQUENCE (1-letter)
PEPTIDE SEQUENCE (3-letter)
N-TERMINAL MODIFICATION
C-TERMINAL MODIFICATION
CHEMICAL MODIFICATION
PEPTIDE LENGTH
PEPTIDE CONFORMATION
PEPTIDE NATURE
SOURCE/ORIGIN OF PEPTIDE
SMILES
CELL LINE
In vitro
CONCENTRATION
In vitro
METHOD
In vitro
RESULT
ANIMAL MODEL
In vivo
CONCENTRATION
In vivo
MODE OF DELIVERY
In vivo
METHOD
In vivo
RESULT
ACTION
TRANSPORT TYPE
SUBCELLULAR LOCALISATION
COMBINATION
PHYSICAL CONDITION
RESPONSE
RESULT
LABEL
PMID
b3pdb_0001
Mtfpep
DSSHAFTLDELR
AspSerSerHisAlaPheThrLeuAspGluLeuArg
NA
Polyethylene glycol (PEG)4 linker
NA
12
Linear
NA
Melanotransferrin
N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
NA
NA
NA
NA
Mice
2 MTfpep per NIP228 antibody
Intravenous
3D confocal fluorescence microscopy
Two times greater fractional fluorescence was measured in the brain parenchyma.
It delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates
Transcytosis
Surface of normal brain endothelial cells, the main constituent of the BBB, and is able to cross thr
Successfully delivers therapeutic amounts of an an
Neuropathic pain
Stability/half life
5.5 days
NA
29845881
b3pdb_0005
R-Rfa
SLKPAANLPLRF
SerLeuLysProAlaAlaAsnLeuProLeuArgPhe
NA
NA
5(6)-carboxyfluorescein attched to peptide
12
Linear
NA
Dodeca-neuropeptide (SLKPAANLPLRF) of frog brain.
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O
NA
NA
NA
NA
Rat primary cortical neurons
NA
Intraperitoneal
Fourier Transform Infrared Spectroscopy
Inhibition of Aβ fibrillation
It inhibits Aβ fibrillization, moderately binds with tubulin and promotes tubulin polymerization as
NA
NA
NA
Alzheimer’s disease
NA
NA
NA
30408415
b3pdb_0038
ApoB11
RLTRKRGLKLA
ArgLeuThrArgLysArgGlyLeuLysLeuAla
NA
5 Gly (G) and 9 Arg (R) amino acids to the C-termi
Coupled with a 9-amiNA acid arginine linker
11
NA
NA
ApoB38 peptide
N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)O
Mouse cholinergic cell line Neuro2A (N2A)
100000 cells/well
Laser scanning confocal microscopy
It crosses the BBB with conguagted siRNA for alpha-syn.
Transgenic Mice
50 microgram
Intraperitoneal
Laser scanning confocal microscopy
It can transport siα-syn across the BBB as a therapeutic option for synucleinopathies.
It showed reduced accumulation of α-syn associated with amelioration of the neurodegenerative and i
NA
Neurons and glial cellsexhibiting α-syn accumulation
Combined with siRNA for alpha-syn
Lewy body disease
NA
NA
NA
30849508
b3pdb_0039
C2-9r
CDIFTNSRGKRA
CysAspIlePheThrAsnSerArgGlyLysArgAla
NA
4 Gly (G) and nine d-Arg (9r) residues to the Cter
Coupled with a 9-amiNA acid arginine linker
12
NA
NA
rhabdovirus glycoprotein
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)O
Mouse cholinergic cell line Neuro2A (N2A)
100000 cells/well
Laser scanning confocal microscopy
It crosses the BBB with conguagted siRNA for alpha-syn.
Transgenic Mice
50 microgram
Intraperitoneal
Laser scanning confocal microscopy
It can transport siα-syn across the BBB as a therapeutic option for synucleinopathies.
It showed reduced accumulation of α-syn associated with amelioration of the neurodegenerative and i
NA
Neurons and glial cellsexhibiting α-syn accumulation
Combined with siRNA for alpha-syn
Lewy body disease
NA
NA
NA
30849508
b3pdb_0052
Phage clone 1.2
VAARTGEIYVPW
ValAlaAlaArgThrGlyGluIleTyrValProTrp
NA
NA
NA
12
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)O
SH-SY5Y cells
NA
UHPLC-MS/MS
The phage display adverses the BBB with the peptide.
NA
NA
NA
NA
NA
Peptides bound specifically to primary endothelial cells and could traverse the BBB.
Transcytosis
NA
Combined with phage display
NA
Stability/half life
1.5 x 10e-6 cm/s
NA
32079185
b3pdb_0053
Phage clone 1.3
GLHTSATNLYLH
GlyLeuHisThrSerAlaThrAsnLeuTyrLeuHis
NA
NA
NA
12
Linear
Cationic
Chemically synthesized
NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)O
SH-SY5Y cells
NA
UHPLC-MS/MS
The phage display adverses the BBB with the peptide.
NA
NA
NA
NA
NA
Peptides bound specifically to primary endothelial cells and could traverse the BBB.
Transcytosis
NA
Combined with phage display
NA
Stability/half life
3.3 x 10e-7 cm/s
NA
32079185
b3pdb_0054
Tfr1
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
FAM is conjgated at the N-terminal
NA
NA
12
Linear
NA
Chemically synthesized
N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0072
Neurotensin
ELYENKPRRPYIL
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
NA
NA
NA
13
Tridecapeptide
NA
bovine hypothalamus
N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
NA
NA
NA
NA
Adult male Swiss-Webster mice
NA
NA
Student's t-test (two-tailed) and Mann-Whitney U-test
NA
Not able to cross the BBB in sufficient quantities to exert direct brain effects. Can modify the sed
NA
NA
NA
NA
NA
NA
NA
406965
b3pdb_0135
G23
HLNILSTLWKYR
HisLeuAsnIleLeuSerThrLeuTrpLysTyrArg
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
hCMEC/D3
NA
Fluoroscent measure
G23 peptide can cross basal layer
NA
NA
NA
NA
NA
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0136
G23
HLNILSTLWKYR
HisLeuAsnIleLeuSerThrLeuTrpLysTyrArg
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.052 + 0.019 of fluoroscent measured in btain tissue after 4 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0137
G23
HLNILSTLWKYR
HisLeuAsnIleLeuSerThrLeuTrpLysTyrArg
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.047 + 0.031 of fluoroscent measured in btain tissue after 24 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0138
Scr-G23
KISHLLNYRTWL
LysIleSerHisLeuLeuAsnTyrArgThrTrpLeu
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.013 + 0.006 of fluoroscent measured in btain tissue after 4 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0139
Scr-G23
KISHLLNYRTWL
LysIleSerHisLeuLeuAsnTyrArgThrTrpLeu
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.008 + 0.002 of fluoroscent measured in btain tissue after 24 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0147
Goldnanoparticle con
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
NA
Conjugated with CLPFFD goldnaNAparticle
12
Linear
Cationic
Chemically synthesized
NA
NA
NA
NA
NA
Adult Sprague-Dawley rats
1.86 mg/Kg
Intraperitoneal
Instrumental neutron activation analysis and Nissl staining
Conjugate was found to cross blodd brain barrier; does not effect mice survival; no toxicity as meas
NA
NA
NA
NA
Alzheimer
NA
NA
NA
22795856
b3pdb_0160
ASA-Tat
YGRKKRRQRRR
TyrGlyArgLysLysArgArgGlnArgArgArg
Conjugated with ASA drug
NA
NA
11
Linear
NA
NA
NA
CHO cell line
2.5 microgram/ ml
cellular uptake assay
12.6 % cellular uptake
NA
NA
NA
NA
NA
NA
Transendocytosis
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0165
ASA-Tat
YGRKKRRQRRR
TyrGlyArgLysLysArgArgGlnArgArgArg
Conjugated with ASA drug
NA
NA
11
Linear
NA
NA
NA
bEND cell line
2.5 microgram/ ml
cellular uptake assay
16.6 % cellular uptake
NA
NA
NA
NA
NA
NA
Transendocytosis
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0170
ASA-Tat
YGRKKRRQRRR
TyrGlyArgLysLysArgArgGlnArgArgArg
Conjugated with ASA drug
NA
NA
11
Linear
NA
NA
NA
PBCECs cell line
0.02% cells were added
Basolateral screening assay
100% transfer
NA
NA
NA
NA
NA
NA
Basolateral
NA
NA
Lysosomal disorder
NA
NA
NA
24573272
b3pdb_0177
Parent peptide
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
12.5+/- 3.4 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0178
N-methylaed parent p
T(Nme)H(Nme)RPPM(Nme)WSPVWP
NA
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
9.9+/- 1.6 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0179
Enatiomeric parent p
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
14.5+/- 2.0 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0180
Retro-enantiomeric p
PWVPSWMPPRHT
ProTrpValProSerTrpMetProProArgHisThr
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
21.5+/- 2.8 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0181
Parent peptide
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
14.9+/- 2.5 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0182
N-methylaed parent p
T(Nme)H(Nme)RPPM(Nme)WSPVWP
NA
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
11.7+/- 6.4 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0183
Enatiomeric parent p
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
17.2+/- 1.2 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0184
Retro-enantiomeric p
PWVPSWMPPRHT
ProTrpValProSerTrpMetProProArgHisThr
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
25.1+/- 3.0 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
NA
NA
NA
NA
NA
25650865
b3pdb_0185
Parent peptide
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
16.2+/- 1.3 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
carboxyfluoroscein
Antiallergic drug
NA
NA
NA
25650865
b3pdb_0186
N-methylaed parent p
T(Nme)H(Nme)RPPM(Nme)WSPVWP
NA
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.14.7+/- 0.01 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
H-a(Nme)f-D-2-nal-vlkk-Nh2
Antialzheimer peptide
NA
NA
NA
25650865
b3pdb_0187
Enatiomeric parent p
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.19.2+/- 0.07 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
iron oxide nanoparticle
NA
NA
NA
NA
25650865
b3pdb_0188
Retro-enantiomeric p
PWVPSWMPPRHT
ProTrpValProSerTrpMetProProArgHisThr
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.27+/- 0.03 apparent permeability
NA
NA
NA
NA
NA
NA
can transport cargo
NA
Quantum dots
NA
NA
NA
NA
25650865
b3pdb_0189
Parent peptide
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
17.1+/- 2.6 transport efficiency
NA
NA
NA
NA
NA
NA
can transport cargo
NA
carboxyfluoroscein
Antiallergic drug
NA
NA
NA
25650865
b3pdb_0190
N-methylaed parent p
T(Nme)H(Nme)RPPM(Nme)WSPVWP
NA
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.20+/- 0.01 transport efficiency
NA
NA
NA
NA
NA
NA
can transport cargo
NA
H-a(Nme)f-D-2-nal-vlkk-Nh2
Antialzheimer peptide
NA
NA
NA
25650865
b3pdb_0191
Enatiomeric parent p
THRPPMWSPVWP
ThrHisArgProProMetTrpSerProValTrpPro
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.22+/- 0.05 transport efficiency
NA
NA
NA
NA
NA
NA
can transport cargo
NA
iron oxide nanoparticle
NA
NA
NA
NA
25650865
b3pdb_0192
Retro-enantiomeric p
PWVPSWMPPRHT
ProTrpValProSerTrpMetProProArgHisThr
NA
Amidated
NA
12
Linear
NA
NA
NA
Rat astrocyte
50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.031+/- 0.02 transport efficiency
NA
NA
NA
NA
NA
NA
can transport cargo
NA
Quantum dots
NA
NA
NA
NA
25650865
b3pdb_0197
Bacteriophage derive
RRPAPLIMFRMI
ArgArgProAlaProLeuIleMetPheArgMetIle
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0198
Bacteriophage derive
SRYSIGGNNGVT
SerArgTyrSerIleGlyGlyAsnAsnGlyValThr
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0202
Bacteriophage derive
RSTASTSYPFFF
ArgSerThrAlaSerThrSerTyrProPhePhePhe
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0203
Bacteriophage derive
YAWGGGWVLQWF
TyrAlaTrpGlyGlyGlyTrpValLeuGlnTrpPhe
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0204
Bacteriophage derive
DAAESVLVGTVR
AspAlaAlaGluSerValLeuValGlyThrValArg
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0205
Bacteriophage derive
ISNRSHKGLMVG
IleSerAsnArgSerHisLysGlyLeuMetValGly
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0206
Bacteriophage derive
YNQSLLQGYRYW
TyrAsnGlnSerLeuLeuGlnGlyTyrArgTyrTrp
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0208
Bacteriophage derive
MRWFFSHASQGR
MetArgTrpPhePheSerHisAlaSerGlnGlyArg
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0209
Bacteriophage derive
RLSSVDSDLSGC
ArgLeuSerSerValAspSerAspLeuSerGlyCys
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0210
Bacteriophage derive
GRPQKINGARVC
GlyArgProGlnLysIleAsnGlyAlaArgValCys
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0212
Bacteriophage derive
KVAWRVFSLFWK
LysValAlaTrpArgValPheSerLeuPheTrpLys
NA
NA
NA
12
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0213
Bacteriophage derive
GFVRFRLSNTR
GlyPheValArgPheArgLeuSerAsnThrArg
NA
NA
NA
11
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0233
Protamine
VSRRRRRRGGRRRR
ValSerArgArgArgArgArgArgGlyGlyArgArgArgArg
NA
NA
NA
13
Linear
Cationic
Derived from protamine
NA
NA
NA
NA
NA
BALB/c mice
10 microliter per nostril
Intranasal
In vivo imaging
Peptide + BSA combination deleiveerd in brain olfactory bulb and littlebit in cerebral
peptide can deliver drug into brain tissue
NA
NA
Peptide+BSA
NA
NA
NA
NA
27471676
b3pdb_0234
PepH1
VQQLTKRFSL
ValGlnGlnLeuThrLysArgPheSerLeu
NA
NA
NA
14
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for TcPz
73.83+/- 9.40
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
b3pdb_0236
PepH3
AGILKRW
AlaGlyIleLeuLysArgTrp
NA
NA
NA
14
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for TcPz
67.33+/- 1.20
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
b3pdb_0238
PepH1
VQQLTKRFSL
ValGlnGlnLeuThrLysArgPheSerLeu
NA
NA
NA
14
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for gaNODA
71.47+/- 3.70
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
b3pdb_0240
PepH3
AGILKRW
AlaGlyIleLeuLysArgTrp
NA
NA
NA
14
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for gaNODA
72.63 +/- 0.70
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
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IIITD/CB
Raghava's Group
IMTECH
CellPPDMOD