Browse result page of B3Pdb

The total number entries retrieved from this search are 235, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0002Tf-PFVPFVYLIProPheValTyrLeuIleNANANA6LinearCationicChemically synthesizedN1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)OGlioblastoma (U87), brain endothelial (bEnd.3), anNABy measuring the flux of sodium fluorescence (Na-F) and TEERThe transport of Tf-PFV liposomes across the endothelial barrier layer into tumor grown in the porouIn vitro brain modelNANANANA The dual functionalized liposomes showed significantly higher cellular uptake as well as increased t Transcytosis NA Combination with the transferrin protein Glioblastoma multiforme NA NA NA 30261346
b3pdb_0006NR2B9cKLSSIESDVLysLeuSerSerIleGluSerAspValNANANA9NANANAN[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)ONANANANARatNAIntranasalHPLC-MS/MSNR2B9c-WGA-NPs are able to bypass the BBB and effectively transport NR2B9c into the brain and neuron It can protect neurons against excitotoxicity, reduce ischemic brain injury and ameliorate neurologi transcytosis NA NR2B9c is combined with WGA-modified nanoparticles ischemic stroke NA NA NA 30428334
b3pdb_0007D-T7HRPYIAHCHisArgProTyrIleAlaHisCysNACysteine on C-terminalNA7LinearNAChemically synthesizedN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CS)C(=O)ObEnd.3 and c6 cellsNAConfocal microscopyIt crosses the BBB.MicePTX-1.7 mg/kg, CD-3.6 mg/kgIntravenous NANA D-T7 Peptide Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Ant NA NA Combined with Cediranib and Paclitaxel. Glioma Stability/half life 3.31-fold higher than saline NA 30525386
b3pdb_0040AEP-dendronLRKLRKRLLRLeuArgLysLeuArgLysArgLeuLeuArgAEP attached at N-terminalNANA10LinearCationicApoE proteinN[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)ObEnd.3 Cell Line50000 cells per cm squareLaser Scanning Confocal Microscopy (LSCM)LSCM showed the cellular uptake of the RMT-competent AEP-dendron.NANANANANA Successful synthesis of dendronised carrier systems with the potential to act as carriers for improv Receptor-mediated transcytosis NA Comined NA NA NA NA 30972332
b3pdb_0050DeltorphanYAFDVVGTyr-(D)Ala-Phe-Asp-Val-Val-Gly-NH2NAAmide group is attachedNA7LinearNAChemically synthesizedN[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)ONANANANAC57BL6 miceNAIntravenous Confocal microscopyPresence of engineered nano particles within the brain parenchyma with particular focus on hippocamp Opioid-derived peptides featured by specific helix-like conformation as possible ligands to engineer NA CNS parenchyma Comined NA NA NA NA 32479916
b3pdb_0051SLSSLSHSPQSerLeuSerHisSerProGlnNANANA7CyclicNeutralChemically synthesizedN[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)OhCMEC/D3 cell monolayers200000 cells per wellConfocal microscopyIt promoted phage permeation across the hCMEC/D3 cell monolayer.MiceNAIntravenous Plaque formation assayCyclic SLS peptide facilitated phage permeation across the mouse BBB in vivo BBB-permeable cyclic SLS heptapeptide for brain delivery of macromolecules via macropinocytosis and Macropinocytosis Brain parenchyma Combined with M13 phage NA NA NA NA 32135226
b3pdb_0055Tfr2HAIYPRHHisAlaIleTyrProArgHisFAM is conjgated at the N-terminalNANA7LinearNAChemically synthesizedN[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)ObEnd.3 cellsNAImmunofluorescence microscopyIt shows the permeability towards the BBB.NANANANANA These novel peptide conjugates have the capacity to act as promising brain shuttles Receptor-mediated transcytosis NA Combined NA NA NA NA 32055384
b3pdb_0066HAVN1SHAVSSSerHisAlaValSerSerNANANA6CyclicNAChemically synthesizedN[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0068Linear ADTHAVTPPVSHAVThrProProValSerHisAlaValAcetylaed at N-terminalAmide group is attached at C-terminalNA8LinearNAChemically synthesizedN[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0069Cyclic ADTHAVTPPVSHAVThrProProValSerHisAlaValNANANA8CyclicNAChemically synthesizedN[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0070ADTC5CDTPPVCCysAspThrProProValCysNAAmide group is attached at C-terminalNA7CyclicNAChemically synthesizedN[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)ONANANANAC57BL6 miceNAIntracerebral ventricularMass SpectromteryIt is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain. Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA NA NA Combined with monoclonal antibody NA NA NA NA 31683745
b3pdb_0073Delta-sleep inducingWAGGDASGETrp- Ala - Gly - Gly - Asp - Ala- Ser - Gly - GluNANANA9LinearNANANABrainNANANAMale albino adult ratsNANARIA, TLCNA NA NA NA NA NA NA NA NA 583452, 3840534
b3pdb_0074Delta-sleep inducingWAAGDASGETrp- Ala - D-Ala - Gly - Asp - Ala- Ser - Gly - GluNANANA9LinearNANAN[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)OBrainNANANAMale albino adult ratsNANARIA, TLCNA NA NA NA NA NA NA NA NA 583452
b3pdb_0075Delta-sleep inducingWAGADASGETrp- Ala - Gly - D-Ala - Asp - Ala- Ser - Gly - GluNANANA9LinearNANAN[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)OBrainNANANAMale albino adult ratsNANARIA, TLCNA NA NA NA NA NA NA NA NA 583452
b3pdb_0076Delta-sleep inducingAGADASGEAla - Gly - D-Ala - Asp - Ala- Ser - Gly - GluNANANA8LinearNANAN[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)OBrainNANANAMale albino adult ratsNANARIA, TLCNA NA NA NA NA NA NA NA NA 583452
b3pdb_0150MMP-2200Y-D-TGFLS(β-O-Glc)-CONH2Tyr-D-Thr-Gly-Phe-Leu-Ser(β-O-Glc)-CONH2NANAGlycosylated serine residue6LinearNAChemically synthesizedNANANANANAAdult Sprague-Dawley rats10mg/KgIntraperitonealMicrodialysis analysis and LCMS analysisSignificant amount of peptide crosses blood brain barrier after 12 minute and remain stable up to 80 Shows potent analgesic behaviour NA NA NA Parkinson Stability/half life 80 minute NA 23127847
b3pdb_0200Bacteriophage deriveDVAKVSAspValAlaLysValSerNANANA6LinearNAT7 Bacteiophage derivedNANANANANAMale wistar miceNANANANA Can cross BBB as well as Blood CSF barrier Transendocytosis NA NA Alzheimer NA NA NA 26411801
b3pdb_0201Bacteriophage deriveYSMVFVGIKLTyrSerMetValPheValGlyIleLysLeuNANANA10LinearNAT7 Bacteiophage derivedNANANANANAMale wistar miceNANANANA Can cross BBB as well as Blood CSF barrier Transendocytosis NA NA Alzheimer NA NA NA 26411801
b3pdb_0207Bacteriophage deriveIGTLTTIleGlyThrLeuThrThrNANANA6LinearNAT7 Bacteiophage derivedNANANANANAMale wistar miceNANANANA Can cross BBB as well as Blood CSF barrier Transendocytosis NA NA Alzheimer NA NA NA 26411801
b3pdb_0235PepH2KLFMALVAFLRFLTLysLeuPheMetAlaLeuValAlaPheLeuArgPheLeuThrNANANA10LinearCationicDerived from dengue virus capsidNAbEND cell line5 microCi/mlGamma counter radioactivity measure for TcPz9.32+/- 2.50NANANANANA Can cross blood brain barrier as well as shows membrane adsorption Transmigration Can be migrated to liver, kidney etc. NA NA NA NA NA 28263555
b3pdb_0237PepH4KSKAINVLRGFRKEIGRMLNILNLysSerLysAlaIleAsnValLeuArgGlyPheArgLysGluIleGlyArgMetLeuAsnIleLeuAsnNANANA7LinearCationicDerived from dengue virus capsidNAbEND cell line5 microCi/mlGamma counter radioactivity measure for TcPz63.45+/- 1.90NANANANANA Can cross blood brain barrier as well as shows membrane adsorption Transmigration Can be migrated to liver, kidney etc. NA NA NA NA NA 28263555
b3pdb_0239PepH2KLFMALVAFLRFLTLysLeuPheMetAlaLeuValAlaPheLeuArgPheLeuThrNANANA10LinearCationicDerived from dengue virus capsidNAbEND cell line5 microCi/mlGamma counter radioactivity measure for gaNODA13.51 +/- 0.70NANANANANA Can cross blood brain barrier as well as shows membrane adsorption Transmigration Can be migrated to liver, kidney etc. NA NA NA NA NA 28263555
b3pdb_0241PepH4KSKAINVLRGFRKEIGRMLNILNLysSerLysAlaIleAsnValLeuArgGlyPheArgLysGluIleGlyArgMetLeuAsnIleLeuAsnNANANA7LinearCationicDerived from dengue virus capsidNAbEND cell line5 microCi/mlGamma counter radioactivity measure for gaNODA60.79 +/- 2.60NANANANANA Can cross blood brain barrier as well as shows membrane adsorption Transmigration Can be migrated to liver, kidney etc. NA NA NA NA NA 28263555
b3pdb_0260Delta-sleep inducingWAGGDASGETrp- Ala - Gly - Gly - Asp - Ala- Ser - Gly - GluNANANA9NANANABrainNANAMale albino adult ratsNARIA, TLCNANANANA NA NA NA NA NA NA NA NA 583452, 3840534
b3pdb_0268D-[Ala]-Peptide T-AmaSTTTNYT-NH2NANANANA8LinearNAChemically synthesizedNANANAMiceNANANANANANA NA NA NA NA NA NA NA NA 3440215
b3pdb_0299HAV6Ac-SHAVSS-NH2Ac-SerHisAlaValSerSerAsnHis-NH2NANANA6LinearNAEC1 domain of E-cadherinNANANARatNANANANANANA disrupt the BBB and enhance delivery of small molecules into the brain. NA NA NA NA NA NA NA 26705088
b3pdb_0311P021Ac-DGGLAG-NH2Ac-AspGlyGlyLeuAlaGlyAsnHis-NH2NANANA6PentamerNANANANANANANANANANANANA NA NA NA NA NA NA NA NA 27400746
b3pdb_0336WSWSYPGWSWNANANANA7NANANANANANANANAretro-inverso isomerization techniqueNANANANA quorum sensing peptide NA NA NA NA NA NA NA 28548480
b3pdb_0338analog 8YPW-(S,S)-AMBP-NH2H-Dmt-Pro-Trp-(S,S)-AMBF-NH2NANANA8LinearNANANANANANANANANANANANA NA NA NA NA NA NA NA NA 28567476
b3pdb_0352PepNegSGTQEEYNANANANA7LinearNANANANANANANANANANANANA NA NA NA NA NA NA NA NA 29057814
b3pdb_0362opioid glycopeptide Y-D-TGFLS(β-O-Glc)-CONH2Tyr-D-Thr-Gly-Phe-Leu-Ser(β-O-Glc)-CONH2NANANA6LinearNANANANANANAAdult Sprague-Dawley ratsNANANAHigh penetration NA NA NA NA NA NA NA NA 23127847
b3pdb_0386IlantideSGRKSSKMQASerGlyArgLysSerSerLysMetGlnAlaNANANA10LinearNAHEK-Blue IL-1β cells, HEK-Blue IL-6 cellsNANANAratNANANANANANA NA NA NA NA NA NA NA NA 24490798
b3pdb_0404VasopressinCYFQNCPRGCys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-GlyNANACys1-Cys69LinearNAhuman,bovine,mouse,ratO=C(O)CNC(=O)[C@@H](NC(=O)[C@@H]4N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)Cc3ccccc3)CCC(=O)N)CC(=O)N)CCC4)CCCNC(=[N@H])NNANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.00011 mL/(g x min) Direct iodination 17950952
b3pdb_0405VasopressinCYFQNCPRGCys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-GlyNANACys1-Cys69LinearNAhuman,bovine,mouse,ratO=C(O)CNC(=O)[C@@H](NC(=O)[C@@H]4N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)Cc3ccccc3)CCC(=O)N)CC(=O)N)CCC4)CCCNC(=[N@H])NNANACapillary depletionNANANANANANA NA saturable NA NA NA Capillary depletion (parenchyma/serum) 0.00827 ml/g Direct iodination 17950952
b3pdb_0406OxytocinCYIQNCPLGCys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-GlyCys1-Cys69LinearNAhuman,bovine,mouse,ratO=C(O)CNC(=O)[C@H](NC(=O)[C@H]3N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)[C@@H](C)CC)CCC(=O)N)CC(=O)N)CCC3)CC(C)CNANANANANANAIntravenous NANA NA Permeability NA NA NA % injected dose 0.018 %/g H3/C14 10976589
b3pdb_0407OxytocinCYIQNCPLGCys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-GlyCys1-Cys69LinearNAhuman,bovine,mouse,ratO=C(O)CNC(=O)[C@H](NC(=O)[C@H]3N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)[C@@H](C)CC)CCC(=O)N)CC(=O)N)CCC3)CC(C)CNANANANANANAIntravenous NANA NA Permeability NA NA NA Peak response 1.09 µL/(g x min) H3/C14 10976589
b3pdb_0408OxytocinCYIQNCPLGCys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-GlyCys1-Cys69LinearNAhuman,bovine,mouse,ratO=C(O)CNC(=O)[C@H](NC(=O)[C@H]3N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)[C@@H](C)CC)CCC(=O)N)CC(=O)N)CCC3)CC(C)CNANANANANANAIntracarotid injectionNANA NA Permeability NA NA NA Volume of donor compartment 0.00815 ml/g H3/C14 10976589
b3pdb_0415OctreotidefCFwKTCT(D)Phe-Cys-Phe-(D)Trp-Lys-Thr-Cys-ThrNANACys2-Cys78LinearNAChemically synthesizedO=C(O)[C@@H](NC(=O)[C@H]2NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](N)Cc1ccccc1)CSSC2)Cc3ccccc3)Cc5c4ccccc4nc5)CCCCN)[C@H](O)C)[C@H](O)CNANANANANANANANANA NA NA NA NA NA NA NA NA NA
b3pdb_0416VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANANANANANAIntravenous NANA NA non saturable NA NA NA Unidirectional influx rate constant 0.0000923 mL/(g x min) Direct iodination 1975697
b3pdb_0417VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANANANANANAIntravenous NANA NA Permeability NA NA NA Initial distribution volume 0.0137 ml/g Direct iodination 1975697
b3pdb_0418VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANANANANANAIntravenous NANA NA Permeability NA NA NA half life, serum 1.05 min Direct iodination 1975697
b3pdb_0419VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANAEfflux study ICUNANANANANANA NA Permeability NA NA NA half life, brain 24 min Direct iodination 1975697
b3pdb_0420VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANAEfflux study ICUNANANANANANA NA saturable NA NA NA Brain elemination rate constant 0.029 min-1 Direct iodination 1975697
b3pdb_0421VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANANANANANAin situ brain perfusionNANA NA non saturable NA NA NA Permeability surface area cofficient 20.3 µL/(g x min) Direct iodination 1975697
b3pdb_0422VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANAHPLCNANANANANANA NA NA NA NA NA % injected dose 41.6 %/g Direct iodination 1975697
b3pdb_0423VapreotidefCYwKVCW-NH2(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2NANACys2-Cys78LinearNAChemically synthesizedO=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7NANAHPLCNANANANANANA NA NA NA NA NA % injected dose 36.9 %/g Direct iodination 1975697
b3pdb_0478Deltorphin I, [D-AlaYaFDVVG-NH2Tyr-(D)Ala-Phe-Asp-Val-Val-Gly-NH2NA7LinearNAGila monsterO=C(N)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C)Cc2ccccc2)CC(=O)O)C(C)C)C(C)CNANABMECNANANABMECNANA NA (saturable) NA NA NA Permeability coefficient 0.00003788 cm/s NA 9152390
b3pdb_0479Deltorphin II, [D-AlYaFEVVG-NH2Tyr-(D)Ala-Phe-Glu-Val-Val-Gly-NH2NA7LinearNAhuman,mouse,ratO=C(N)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C)Cc2ccccc2)CCC(=O)O)C(C)C)C(C)CNANABMECNANANABMECNANA NA (saturable) NA NA NA Permeability coefficient 0.00003915 cm/s NA 9152390
b3pdb_0575BiphalinYaGF-NH-NH-FGaYTyr-(D)Ala-Gly-Phe-NH-NH-Phe-Gly-(D)Ala-TyrNANANA8LinearNAcatO=C(N[C@@H](C(=O)NCC(=O)N[C@H](C(=O)NNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C)Cc2ccccc2)Cc3ccccc3)C)[C@@H](N)Cc4ccc(O)cc4NANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Unidirectional flux rate constant 0.001 mL/(g x min) Direct iodination 11714884
b3pdb_0576BiphalinYaGF-NH-NH-FGaYTyr-(D)Ala-Gly-Phe-NH-NH-Phe-Gly-(D)Ala-TyrNANANA8LinearNAcatO=C(N[C@@H](C(=O)NCC(=O)N[C@H](C(=O)NNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C)Cc2ccccc2)Cc3ccccc3)C)[C@@H](N)Cc4ccc(O)cc4NANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Initial distribution vaolume 0.0097 ml/g Direct iodination 11714884