Home
Statistics
Acknowledgment
Enquire
Keyword Search
Complex Search
Segment Search
Peptide Mapping
Browse On
Mode of delivery
Animal model
Origin/Source
Peptide Length
Similarity
BLAST Search
Smith-Waterman
General
Help or Guide
Data Submission
Curators
Developers
Contact Us
Browse result page of B3Pdb
The total number entries retrieved from this search are
235
, scroll left/right for detailed information.
B3pdbID
PEPTIDE NAME
PEPTIDE SEQUENCE (1-letter)
PEPTIDE SEQUENCE (3-letter)
N-TERMINAL MODIFICATION
C-TERMINAL MODIFICATION
CHEMICAL MODIFICATION
PEPTIDE LENGTH
PEPTIDE CONFORMATION
PEPTIDE NATURE
SOURCE/ORIGIN OF PEPTIDE
SMILES
CELL LINE
In vitro
CONCENTRATION
In vitro
METHOD
In vitro
RESULT
ANIMAL MODEL
In vivo
CONCENTRATION
In vivo
MODE OF DELIVERY
In vivo
METHOD
In vivo
RESULT
ACTION
TRANSPORT TYPE
SUBCELLULAR LOCALISATION
COMBINATION
PHYSICAL CONDITION
RESPONSE
RESULT
LABEL
PMID
b3pdb_0002
Tf-PFV
PFVYLI
ProPheValTyrLeuIle
NA
NA
NA
6
Linear
Cationic
Chemically synthesized
N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O
Glioblastoma (U87), brain endothelial (bEnd.3), an
NA
By measuring the flux of sodium fluorescence (Na-F) and TEER
The transport of Tf-PFV liposomes across the endothelial barrier layer into tumor grown in the porou
In vitro brain model
NA
NA
NA
NA
The dual functionalized liposomes showed significantly higher cellular uptake as well as increased t
Transcytosis
NA
Combination with the transferrin protein
Glioblastoma multiforme
NA
NA
NA
30261346
b3pdb_0006
NR2B9c
KLSSIESDV
LysLeuSerSerIleGluSerAspVal
NA
NA
NA
9
NA
NA
NA
N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)O
NA
NA
NA
NA
Rat
NA
Intranasal
HPLC-MS/MS
NR2B9c-WGA-NPs are able to bypass the BBB and effectively transport NR2B9c into the brain and neuron
It can protect neurons against excitotoxicity, reduce ischemic brain injury and ameliorate neurologi
transcytosis
NA
NR2B9c is combined with WGA-modified nanoparticles
ischemic stroke
NA
NA
NA
30428334
b3pdb_0007
D-T7
HRPYIAHC
HisArgProTyrIleAlaHisCys
NA
Cysteine on C-terminal
NA
7
Linear
NA
Chemically synthesized
N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CS)C(=O)O
bEnd.3 and c6 cells
NA
Confocal microscopy
It crosses the BBB.
Mice
PTX-1.7 mg/kg, CD-3.6 mg/kg
Intravenous
NA
NA
D-T7 Peptide Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Ant
NA
NA
Combined with Cediranib and Paclitaxel.
Glioma
Stability/half life
3.31-fold higher than saline
NA
30525386
b3pdb_0040
AEP-dendron
LRKLRKRLLR
LeuArgLysLeuArgLysArgLeuLeuArg
AEP attached at N-terminal
NA
NA
10
Linear
Cationic
ApoE protein
N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
bEnd.3 Cell Line
50000 cells per cm square
Laser Scanning Confocal Microscopy (LSCM)
LSCM showed the cellular uptake of the RMT-competent AEP-dendron.
NA
NA
NA
NA
NA
Successful synthesis of dendronised carrier systems with the potential to act as carriers for improv
Receptor-mediated transcytosis
NA
Comined
NA
NA
NA
NA
30972332
b3pdb_0050
Deltorphan
YAFDVVG
Tyr-(D)Ala-Phe-Asp-Val-Val-Gly-NH2
NA
Amide group is attached
NA
7
Linear
NA
Chemically synthesized
N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)O
NA
NA
NA
NA
C57BL6 mice
NA
Intravenous
Confocal microscopy
Presence of engineered nano particles within the brain parenchyma with particular focus on hippocamp
Opioid-derived peptides featured by specific helix-like conformation as possible ligands to engineer
NA
CNS parenchyma
Comined
NA
NA
NA
NA
32479916
b3pdb_0051
SLS
SLSHSPQ
SerLeuSerHisSerProGln
NA
NA
NA
7
Cyclic
Neutral
Chemically synthesized
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O
hCMEC/D3 cell monolayers
200000 cells per well
Confocal microscopy
It promoted phage permeation across the hCMEC/D3 cell monolayer.
Mice
NA
Intravenous
Plaque formation assay
Cyclic SLS peptide facilitated phage permeation across the mouse BBB in vivo
BBB-permeable cyclic SLS heptapeptide for brain delivery of macromolecules via macropinocytosis and
Macropinocytosis
Brain parenchyma
Combined with M13 phage
NA
NA
NA
NA
32135226
b3pdb_0055
Tfr2
HAIYPRH
HisAlaIleTyrProArgHis
FAM is conjgated at the N-terminal
NA
NA
7
Linear
NA
Chemically synthesized
N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)O
bEnd.3 cells
NA
Immunofluorescence microscopy
It shows the permeability towards the BBB.
NA
NA
NA
NA
NA
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
NA
Combined
NA
NA
NA
NA
32055384
b3pdb_0066
HAVN1
SHAVSS
SerHisAlaValSerSer
NA
NA
NA
6
Cyclic
NA
Chemically synthesized
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)O
NA
NA
NA
NA
C57BL6 mice
NA
Intracerebral ventricular
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
NA
NA
Combined with monoclonal antibody
NA
NA
NA
NA
31683745
b3pdb_0068
Linear ADTHAV
TPPVSHAV
ThrProProValSerHisAlaVal
Acetylaed at N-terminal
Amide group is attached at C-terminal
NA
8
Linear
NA
Chemically synthesized
N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O
NA
NA
NA
NA
C57BL6 mice
NA
Intracerebral ventricular
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
NA
NA
Combined with monoclonal antibody
NA
NA
NA
NA
31683745
b3pdb_0069
Cyclic ADTHAV
TPPVSHAV
ThrProProValSerHisAlaVal
NA
NA
NA
8
Cyclic
NA
Chemically synthesized
N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O
NA
NA
NA
NA
C57BL6 mice
NA
Intracerebral ventricular
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
NA
NA
Combined with monoclonal antibody
NA
NA
NA
NA
31683745
b3pdb_0070
ADTC5
CDTPPVC
CysAspThrProProValCys
NA
Amide group is attached at C-terminal
NA
7
Cyclic
NA
Chemically synthesized
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)O
NA
NA
NA
NA
C57BL6 mice
NA
Intracerebral ventricular
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
NA
NA
Combined with monoclonal antibody
NA
NA
NA
NA
31683745
b3pdb_0073
Delta-sleep inducing
WAGGDASGE
Trp- Ala - Gly - Gly - Asp - Ala- Ser - Gly - Glu
NA
NA
NA
9
Linear
NA
NA
NA
Brain
NA
NA
NA
Male albino adult rats
NA
NA
RIA, TLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
583452, 3840534
b3pdb_0074
Delta-sleep inducing
WAAGDASGE
Trp- Ala - D-Ala - Gly - Asp - Ala- Ser - Gly - Glu
NA
NA
NA
9
Linear
NA
NA
N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O
Brain
NA
NA
NA
Male albino adult rats
NA
NA
RIA, TLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
583452
b3pdb_0075
Delta-sleep inducing
WAGADASGE
Trp- Ala - Gly - D-Ala - Asp - Ala- Ser - Gly - Glu
NA
NA
NA
9
Linear
NA
NA
N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O
Brain
NA
NA
NA
Male albino adult rats
NA
NA
RIA, TLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
583452
b3pdb_0076
Delta-sleep inducing
AGADASGE
Ala - Gly - D-Ala - Asp - Ala- Ser - Gly - Glu
NA
NA
NA
8
Linear
NA
NA
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O
Brain
NA
NA
NA
Male albino adult rats
NA
NA
RIA, TLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
583452
b3pdb_0150
MMP-2200
Y-D-TGFLS(β-O-Glc)-CONH2
Tyr-D-Thr-Gly-Phe-Leu-Ser(β-O-Glc)-CONH2
NA
NA
Glycosylated serine residue
6
Linear
NA
Chemically synthesized
NA
NA
NA
NA
NA
Adult Sprague-Dawley rats
10mg/Kg
Intraperitoneal
Microdialysis analysis and LCMS analysis
Significant amount of peptide crosses blood brain barrier after 12 minute and remain stable up to 80
Shows potent analgesic behaviour
NA
NA
NA
Parkinson
Stability/half life
80 minute
NA
23127847
b3pdb_0200
Bacteriophage derive
DVAKVS
AspValAlaLysValSer
NA
NA
NA
6
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0201
Bacteriophage derive
YSMVFVGIKL
TyrSerMetValPheValGlyIleLysLeu
NA
NA
NA
10
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0207
Bacteriophage derive
IGTLTT
IleGlyThrLeuThrThr
NA
NA
NA
6
Linear
NA
T7 Bacteiophage derived
NA
NA
NA
NA
NA
Male wistar mice
NA
NA
NA
NA
Can cross BBB as well as Blood CSF barrier
Transendocytosis
NA
NA
Alzheimer
NA
NA
NA
26411801
b3pdb_0235
PepH2
KLFMALVAFLRFLT
LysLeuPheMetAlaLeuValAlaPheLeuArgPheLeuThr
NA
NA
NA
10
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for TcPz
9.32+/- 2.50
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
b3pdb_0237
PepH4
KSKAINVLRGFRKEIGRMLNILN
LysSerLysAlaIleAsnValLeuArgGlyPheArgLysGluIleGlyArgMetLeuAsnIleLeuAsn
NA
NA
NA
7
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for TcPz
63.45+/- 1.90
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
b3pdb_0239
PepH2
KLFMALVAFLRFLT
LysLeuPheMetAlaLeuValAlaPheLeuArgPheLeuThr
NA
NA
NA
10
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for gaNODA
13.51 +/- 0.70
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
b3pdb_0241
PepH4
KSKAINVLRGFRKEIGRMLNILN
LysSerLysAlaIleAsnValLeuArgGlyPheArgLysGluIleGlyArgMetLeuAsnIleLeuAsn
NA
NA
NA
7
Linear
Cationic
Derived from dengue virus capsid
NA
bEND cell line
5 microCi/ml
Gamma counter radioactivity measure for gaNODA
60.79 +/- 2.60
NA
NA
NA
NA
NA
Can cross blood brain barrier as well as shows membrane adsorption
Transmigration
Can be migrated to liver, kidney etc.
NA
NA
NA
NA
NA
28263555
b3pdb_0260
Delta-sleep inducing
WAGGDASGE
Trp- Ala - Gly - Gly - Asp - Ala- Ser - Gly - Glu
NA
NA
NA
9
NA
NA
NA
Brain
NA
NA
Male albino adult rats
NA
RIA, TLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
583452, 3840534
b3pdb_0268
D-[Ala]-Peptide T-Am
aSTTTNYT-NH2
NA
NA
NA
NA
8
Linear
NA
Chemically synthesized
NA
NA
NA
Mice
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
3440215
b3pdb_0299
HAV6
Ac-SHAVSS-NH2
Ac-SerHisAlaValSerSerAsnHis-NH2
NA
NA
NA
6
Linear
NA
EC1 domain of E-cadherin
NA
NA
NA
Rat
NA
NA
NA
NA
NA
NA
disrupt the BBB and enhance delivery of small molecules into the brain.
NA
NA
NA
NA
NA
NA
NA
26705088
b3pdb_0311
P021
Ac-DGGLAG-NH2
Ac-AspGlyGlyLeuAlaGlyAsnHis-NH2
NA
NA
NA
6
Pentamer
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
27400746
b3pdb_0336
WSW
SYPGWSW
NA
NA
NA
NA
7
NA
NA
NA
NA
NA
NA
NA
NA
retro-inverso isomerization technique
NA
NA
NA
NA
quorum sensing peptide
NA
NA
NA
NA
NA
NA
NA
28548480
b3pdb_0338
analog 8
YPW-(S,S)-AMBP-NH2
H-Dmt-Pro-Trp-(S,S)-AMBF-NH2
NA
NA
NA
8
Linear
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
28567476
b3pdb_0352
PepNeg
SGTQEEY
NA
NA
NA
NA
7
Linear
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
29057814
b3pdb_0362
opioid glycopeptide
Y-D-TGFLS(β-O-Glc)-CONH2
Tyr-D-Thr-Gly-Phe-Leu-Ser(β-O-Glc)-CONH2
NA
NA
NA
6
Linear
NA
NA
NA
NA
NA
NA
Adult Sprague-Dawley rats
NA
NA
NA
High penetration
NA
NA
NA
NA
NA
NA
NA
NA
23127847
b3pdb_0386
Ilantide
SGRKSSKMQA
SerGlyArgLysSerSerLysMetGlnAla
NA
NA
NA
10
Linear
NA
HEK-Blue IL-1β cells, HEK-Blue IL-6 cells
NA
NA
NA
rat
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
24490798
b3pdb_0404
Vasopressin
CYFQNCPRG
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly
NA
NA
Cys1-Cys6
9
Linear
NA
human,bovine,mouse,rat
O=C(O)CNC(=O)[C@@H](NC(=O)[C@@H]4N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)Cc3ccccc3)CCC(=O)N)CC(=O)N)CCC4)CCCNC(=[N@H])N
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
Unidirectional influx rate constant
0.00011 mL/(g x min)
Direct iodination
17950952
b3pdb_0405
Vasopressin
CYFQNCPRG
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly
NA
NA
Cys1-Cys6
9
Linear
NA
human,bovine,mouse,rat
O=C(O)CNC(=O)[C@@H](NC(=O)[C@@H]4N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)Cc3ccccc3)CCC(=O)N)CC(=O)N)CCC4)CCCNC(=[N@H])N
NA
NA
Capillary depletion
NA
NA
NA
NA
NA
NA
NA
saturable
NA
NA
NA
Capillary depletion (parenchyma/serum)
0.00827 ml/g
Direct iodination
17950952
b3pdb_0406
Oxytocin
CYIQNCPLG
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly
Cys1-Cys6
9
Linear
NA
human,bovine,mouse,rat
O=C(O)CNC(=O)[C@H](NC(=O)[C@H]3N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)[C@@H](C)CC)CCC(=O)N)CC(=O)N)CCC3)CC(C)C
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
% injected dose
0.018 %/g
H3/C14
10976589
b3pdb_0407
Oxytocin
CYIQNCPLG
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly
Cys1-Cys6
9
Linear
NA
human,bovine,mouse,rat
O=C(O)CNC(=O)[C@H](NC(=O)[C@H]3N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)[C@@H](C)CC)CCC(=O)N)CC(=O)N)CCC3)CC(C)C
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
Peak response
1.09 µL/(g x min)
H3/C14
10976589
b3pdb_0408
Oxytocin
CYIQNCPLG
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly
Cys1-Cys6
9
Linear
NA
human,bovine,mouse,rat
O=C(O)CNC(=O)[C@H](NC(=O)[C@H]3N(C(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)CSSC1)Cc2ccc(O)cc2)[C@@H](C)CC)CCC(=O)N)CC(=O)N)CCC3)CC(C)C
NA
NA
NA
NA
NA
NA
Intracarotid injection
NA
NA
NA
Permeability
NA
NA
NA
Volume of donor compartment
0.00815 ml/g
H3/C14
10976589
b3pdb_0415
Octreotide
fCFwKTCT
(D)Phe-Cys-Phe-(D)Trp-Lys-Thr-Cys-Thr
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(O)[C@@H](NC(=O)[C@H]2NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](N)Cc1ccccc1)CSSC2)Cc3ccccc3)Cc5c4ccccc4nc5)CCCCN)[C@H](O)C)[C@H](O)C
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
b3pdb_0416
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
non saturable
NA
NA
NA
Unidirectional influx rate constant
0.0000923 mL/(g x min)
Direct iodination
1975697
b3pdb_0417
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
Initial distribution volume
0.0137 ml/g
Direct iodination
1975697
b3pdb_0418
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
NA
NA
NA
NA
Intravenous
NA
NA
NA
Permeability
NA
NA
NA
half life, serum
1.05 min
Direct iodination
1975697
b3pdb_0419
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
Efflux study ICU
NA
NA
NA
NA
NA
NA
NA
Permeability
NA
NA
NA
half life, brain
24 min
Direct iodination
1975697
b3pdb_0420
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
Efflux study ICU
NA
NA
NA
NA
NA
NA
NA
saturable
NA
NA
NA
Brain elemination rate constant
0.029 min-1
Direct iodination
1975697
b3pdb_0421
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
NA
NA
NA
NA
in situ brain perfusion
NA
NA
NA
non saturable
NA
NA
NA
Permeability surface area cofficient
20.3 µL/(g x min)
Direct iodination
1975697
b3pdb_0422
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
HPLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% injected dose
41.6 %/g
Direct iodination
1975697
b3pdb_0423
Vapreotide
fCYwKVCW-NH2
(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2
NA
NA
Cys2-Cys7
8
Linear
NA
Chemically synthesized
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7
NA
NA
HPLC
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
% injected dose
36.9 %/g
Direct iodination
1975697
b3pdb_0478
Deltorphin I, [D-Ala
YaFDVVG-NH2
Tyr-(D)Ala-Phe-Asp-Val-Val-Gly-NH2
NA
7
Linear
NA
Gila monster
O=C(N)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C)Cc2ccccc2)CC(=O)O)C(C)C)C(C)C
NA
NA
BMEC
NA
NA
NA
BMEC
NA
NA
NA
(saturable)
NA
NA
NA
Permeability coefficient
0.00003788 cm/s
NA
9152390
b3pdb_0479
Deltorphin II, [D-Al
YaFEVVG-NH2
Tyr-(D)Ala-Phe-Glu-Val-Val-Gly-NH2
NA
7
Linear
NA
human,mouse,rat
O=C(N)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C)Cc2ccccc2)CCC(=O)O)C(C)C)C(C)C
NA
NA
BMEC
NA
NA
NA
BMEC
NA
NA
NA
(saturable)
NA
NA
NA
Permeability coefficient
0.00003915 cm/s
NA
9152390
b3pdb_0575
Biphalin
YaGF-NH-NH-FGaY
Tyr-(D)Ala-Gly-Phe-NH-NH-Phe-Gly-(D)Ala-Tyr
NA
NA
NA
8
Linear
NA
cat
O=C(N[C@@H](C(=O)NCC(=O)N[C@H](C(=O)NNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C)Cc2ccccc2)Cc3ccccc3)C)[C@@H](N)Cc4ccc(O)cc4
NA
NA
NA
NA
NA
NA
in situ brain perfusion
NA
NA
NA
Permeability
NA
NA
NA
Unidirectional flux rate constant
0.001 mL/(g x min)
Direct iodination
11714884
b3pdb_0576
Biphalin
YaGF-NH-NH-FGaY
Tyr-(D)Ala-Gly-Phe-NH-NH-Phe-Gly-(D)Ala-Tyr
NA
NA
NA
8
Linear
NA
cat
O=C(N[C@@H](C(=O)NCC(=O)N[C@H](C(=O)NNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C)Cc2ccccc2)Cc3ccccc3)C)[C@@H](N)Cc4ccc(O)cc4
NA
NA
NA
NA
NA
NA
in situ brain perfusion
NA
NA
NA
Permeability
NA
NA
NA
Initial distribution vaolume
0.0097 ml/g
Direct iodination
11714884
previous
1
2
3
4
5
next
IIITD/CB
Raghava's Group
IMTECH
CellPPDMOD