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Browse result page of B3Pdb
The total number entries retrieved from this search are
335
, scroll left/right for detailed information.
B3pdbID
PEPTIDE NAME
PEPTIDE SEQUENCE (1-letter)
PEPTIDE SEQUENCE (3-letter)
N-TERMINAL MODIFICATION
C-TERMINAL MODIFICATION
CHEMICAL MODIFICATION
PEPTIDE LENGTH
PEPTIDE CONFORMATION
PEPTIDE NATURE
SOURCE/ORIGIN OF PEPTIDE
SMILES
CELL LINE
In vitro
CONCENTRATION
In vitro
METHOD
In vitro
RESULT
ANIMAL MODEL
In vivo
CONCENTRATION
In vivo
MODE OF DELIVERY
In vivo
METHOD
In vivo
RESULT
ACTION
TRANSPORT TYPE
SUBCELLULAR LOCALISATION
COMBINATION
PHYSICAL CONDITION
RESPONSE
RESULT
LABEL
PMID
b3pdb_0004
NA
SLKP
SerLeuLysPro
NA
NA
5(6)-carboxyfluorescein attched to peptide
4
Linear
NA
Dodeca-neuropeptide (SLKPAANLPLRF) of frog brain.
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)O
NA
NA
NA
NA
Rat primary cortical neurons
NA
Intraperitoneal
Fourier Transform Infrared Spectroscopy
Inhibition of Aβ fibrillation
It inhibits Aβ fibrillization, moderately binds with tubulin and promotes tubulin polymerization as
NA
NA
NA
Alzheimer’s disease
NA
NA
NA
30408415
b3pdb_0047
C-TN-APNPs
CAQK
CysAlaGlnLys
NA
NA
NA
4
Linear
NA
Chemically synthesized
N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O
hCMEC/D3 and NHA cells
NA
TEM imaging
Responsive to thrombin cleavage, reduced the cytotoxicity of Tat-NR2B9c, and increased BBB permeabil
C57BL6 mice
NA
Intravenous
Dynamic light scattering
Better circulation time, better targeting ability and penetrating efficiency to the injured brain, a
Treatment reduced the injury size
NA
NA
Combined with Tat-NR2B9c
Traumatic brain injury
NA
NA
NA
31213815
b3pdb_0048
CC-TN-APNPs
CCAQK
CysCysAlaGlnLys
NA
NA
NA
5
Linear
NA
Chemically synthesized
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O
hCMEC/D3 and NHA cells
NA
TEM imaging
Responsive to thrombin cleavage, reduced the cytotoxicity of Tat-NR2B9c, and increased BBB permeabil
C57BL6 mice
NA
Intravenous
Dynamic light scattering
Better circulation time, better targeting ability and penetrating efficiency to the injured brain, a
Treatment reduced the injury size
NA
NA
Combined with Tat-NR2B9c
Traumatic brain injury
NA
NA
NA
31213815
b3pdb_0067
HAVN2
SHAVS
SerHisAlaValSer
NA
NA
NA
5
Cyclic
NA
Chemically synthesized
N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)O
NA
NA
NA
NA
C57BL6 mice
NA
Intracerebral ventricular
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
NA
NA
Combined with monoclonal antibody
NA
NA
NA
NA
31683745
b3pdb_0077
Leu-Enkephalins
YGGFL
Tyr-Gly-Gly-Phe-Leu
NA
NA
NA
5
Pentapeptide
NA
Intestine and Brain
N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
NA
NA
NA
NA
Adult Wistar SPF rats
NA
NA
NA
NA
morphine-like actions and addictive properties
NA
NA
NA
NA
NA
NA
NA
744146
b3pdb_0078
Met-Enkephalins
YGGFM
Tyr-Gly-Gly-Phe-Met
NA
NA
NA
5
Pentapeptide
NA
Intestine and Brain
N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCSC)C(=O)O
NA
NA
NA
NA
Adult Wistar SPF rats
NA
NA
NA
NA
morphine-like actions and addictive properties
NA
NA
NA
NA
NA
NA
NA
744146
b3pdb_0080
BVDO2
DmtNmeAFS-NH2
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
5 mg/Kg
Intravenous
Hot water tail flick test
70% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0081
BVDO2
DmtNmeAFS-NH3
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
5 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0082
BVDO2
DmtNmeAFS-NH4
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
5 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0083
BVDO2
DmtNmeAFS-NH5
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
5 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0084
BVDO2
DmtNmeAFS-NH6
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
5 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0085
BVDO2
DmtNmeAFS-NH7
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
40% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0086
BVDO2
DmtNmeAFS-NH8
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
80% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0087
BVDO2
DmtNmeAFS-NH9
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
80% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0088
BVDO2
DmtNmeAFS-NH10
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
90% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0089
BVDO2
DmtNmeAFS-NH11
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0090
BVDO2
DmtNmeAFS-NH12
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
10% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0091
BVDO2
DmtNmeAFS-NH13
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
40% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0092
BVDO2
DmtNmeAFS-NH14
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
70% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0093
BVDO2
DmtNmeAFS-NH15
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
80% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0094
BVDO2
DmtNmeAFS-NH16
H-Dmt-Nme-D-Ala-Phe-Ser-NH2
Methylation
Amidation
NA
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
30% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0095
BVDO3
Dmt-N-Me-D-AAbaG-NH2
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
10% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0096
BVDO3
Dmt-N-Me-D-AAbaG-NH3
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
40% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0097
BVDO3
Dmt-N-Me-D-AAbaG-NH4
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
70% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0098
BVDO3
Dmt-N-Me-D-AAbaG-NH5
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
70% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0099
BVDO3
Dmt-N-Me-D-AAbaG-NH6
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
50% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0100
BVDO3
Dmt-N-Me-D-AAbaG-NH7
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
10% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0101
BVDO3
Dmt-N-Me-D-AAbaG-NH8
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
50% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0102
BVDO3
Dmt-N-Me-D-AAbaG-NH9
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
70% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0103
BVDO3
Dmt-N-Me-D-AAbaG-NH10
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
90% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0104
BVDO3
Dmt-N-Me-D-AAbaG-NH11
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
90% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0105
BVDO3
Dmt-N-Me-D-AAbaG-NH12
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
30% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0106
BVDO3
Dmt-N-Me-D-AAbaG-NH13
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
40% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0107
BVDO3
Dmt-N-Me-D-AAbaG-NH14
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
40% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0108
BVDO3
Dmt-N-Me-D-AAbaG-NH15
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
90% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0109
BVDO3
Dmt-N-Me-D-AAbaG-NH16
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.5 mg/Kg
Intravenous
Hot water tail flick test
90% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0110
BVDO3
Dmt-N-Me-D-AAbaG-NH17
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.25mg/Kg
Intravenous
Hot water tail flick test
30% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0111
BVDO3
Dmt-N-Me-D-AAbaG-NH18
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.25mg/Kg
Intravenous
Hot water tail flick test
30% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0112
BVDO3
Dmt-N-Me-D-AAbaG-NH19
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.25mg/Kg
Intravenous
Hot water tail flick test
30% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0113
BVDO3
Dmt-N-Me-D-AAbaG-NH20
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.25mg/Kg
Intravenous
Hot water tail flick test
40% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0114
BVDO3
Dmt-N-Me-D-AAbaG-NH21
Dmt-N-Me-D-Ala-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at alanine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
0.25mg/Kg
Intravenous
Hot water tail flick test
50% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0115
BVDO3
H-Dmt-D-RAbaG-NH2
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
30% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0116
BVDO3
H-Dmt-D-RAbaG-NH3
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0117
BVDO3
H-Dmt-D-RAbaG-NH4
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0118
BVDO3
H-Dmt-D-RAbaG-NH5
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0119
BVDO3
H-Dmt-D-RAbaG-NH6
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
4 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 120 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0120
BVDO3
H-Dmt-D-RAbaG-NH7
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
30% maximum possible effect after 5 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0121
BVDO3
H-Dmt-D-RAbaG-NH8
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
60% maximum possible effect after 15 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0122
BVDO3
H-Dmt-D-RAbaG-NH9
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
90% maximum possible effect after 30 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
b3pdb_0123
BVDO3
H-Dmt-D-RAbaG-NH10
H-Dmt-D-Arg-Aba-Gly-NH2
Methylation
Amidation
Addition of amiNAbenzoic acid at arginine
4
Tetrapeptide
Cationic
NA
NA
NA
NA
NA
NA
C57BL6 mice
1 mg/Kg
Intravenous
Hot water tail flick test
100% maximum possible effect after 60 minutes
Cross BBB and shows morphine like action with analgesic effects
NA
NA
NA
NA
NA
NA
NA
22289619
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IIITD/CB
Raghava's Group
IMTECH
CellPPDMOD