Browse result page of B3Pdb

The total number entries retrieved from this search are 18, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0004NASLKPSerLeuLysProNANA5(6)-carboxyfluorescein attched to peptide4LinearNADodeca-neuropeptide (SLKPAANLPLRF) of frog brain.N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)ONANANANARat primary cortical neuronsNAIntraperitonealFourier Transform Infrared SpectroscopyInhibition of Aβ fibrillation It inhibits Aβ fibrillization, moderately binds with tubulin and promotes tubulin polymerization as NA NA NA Alzheimer’s disease NA NA NA 30408415
b3pdb_0005R-RfaSLKPAANLPLRFSerLeuLysProAlaAlaAsnLeuProLeuArgPheNANA5(6)-carboxyfluorescein attched to peptide12LinearNADodeca-neuropeptide (SLKPAANLPLRF) of frog brain.N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)ONANANANARat primary cortical neuronsNAIntraperitonealFourier Transform Infrared SpectroscopyInhibition of Aβ fibrillation It inhibits Aβ fibrillization, moderately binds with tubulin and promotes tubulin polymerization as NA NA NA Alzheimer’s disease NA NA NA 30408415
b3pdb_0038ApoB11RLTRKRGLKLAArgLeuThrArgLysArgGlyLeuLysLeuAlaNA5 Gly (G) and 9 Arg (R) amino acids to the C-termiCoupled with a 9-amiNA acid arginine linker11NANAApoB38 peptideN[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)OMouse cholinergic cell line Neuro2A (N2A)100000 cells/wellLaser scanning confocal microscopyIt crosses the BBB with conguagted siRNA for alpha-syn.Transgenic Mice50 microgramIntraperitonealLaser scanning confocal microscopyIt can transport siα-syn across the BBB as a therapeutic option for synucleinopathies. It showed reduced accumulation of α-syn associated with amelioration of the neurodegenerative and i NA Neurons and glial cellsexhibiting α-syn accumulation Combined with siRNA for alpha-syn Lewy body disease NA NA NA 30849508
b3pdb_0039C2-9rCDIFTNSRGKRACysAspIlePheThrAsnSerArgGlyLysArgAlaNA4 Gly (G) and nine d-Arg (9r) residues to the CterCoupled with a 9-amiNA acid arginine linker12NANArhabdovirus glycoproteinN[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)OMouse cholinergic cell line Neuro2A (N2A)100000 cells/wellLaser scanning confocal microscopyIt crosses the BBB with conguagted siRNA for alpha-syn.Transgenic Mice50 microgramIntraperitonealLaser scanning confocal microscopyIt can transport siα-syn across the BBB as a therapeutic option for synucleinopathies. It showed reduced accumulation of α-syn associated with amelioration of the neurodegenerative and i NA Neurons and glial cellsexhibiting α-syn accumulation Combined with siRNA for alpha-syn Lewy body disease NA NA NA 30849508
b3pdb_0065Ang-2CTFFYGGSRGKRNNFKTEECysThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluNANANA19LinearNAChemically synthesizedN[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)ONANANANAC57BL6 mice1 mg/mLIntraperitonealFluorescent microscopyLocalization of the nanoparticle within the brain cells, highlighting in particular the neuron accum Brain-targeted PLGA nanoparticles were able to cross the BBB and accumulated in neuronal cells, thus Transcytosis NA Conjugated to poly(lactic-co-glycolic acid) (PLGA) NA NA NA NA 31963430
b3pdb_0140Met-EnkephalinsYGGFMTyr-Gly-Gly-Phe-Met-OHNANANA5LinearNANANANANANANAICR male mice20 micromole/KgIntraperitonealHot water tail flick testAnalgesic effect seen within 2 seconds NA NA NA NA Alzheimer NA NA NA 22778833
b3pdb_0141Leu-EnkephalinsYGGFLTyr-Gly-Gly-Phe-Leu-OHNANANA5LinearNANANANANANANAICR male mice20 micromole/KgIntraperitonealHot water tail flick testAnalgesic effect seen within 2 seconds NA NA NA NA Alzheimer NA NA NA 22778833
b3pdb_0142Fmoc-Met-EnkephalinYGGFMTyr-Gly-Gly-Phe-Met-OHNANAAddition of Fmoc group towards N terminal5LinearNANANANANANANAICR male mice20 micromole/KgIntraperitonealHot water tail flick testAnalgesic effect seen within 2 seconds NA NA NA NA Alzheimer NA NA NA 22778833
b3pdb_0143Fmoc-Leu-EnkephalinsYGGFLTyr-Gly-Gly-Phe-Leu-OHNANAAddition of Fmoc group towards N terminal5LinearNANANANANANANAICR male mice20 micromole/KgIntraperitonealHot water tail flick testAnalgesic effect seen within 4 seconds NA NA NA NA Alzheimer NA NA NA 22778833
b3pdb_0144Fmoc-Leu-EnkephalinsYGGFLTyr-Gly-Gly-Phe-Leu-OHNANAAddition of Fmoc group towards N terminal5LinearNANANANANANANAICR male mice10 micromole/KgIntraperitonealHot water tail flick testAnalgesic effect seen within 4 seconds NA NA NA NA Alzheimer NA NA NA 22778833
b3pdb_0145HOOC-(CH2)10-Leu-EnkYGGFLTyr-Gly-Gly-Phe-Leu-OHAddition of HOOC-(CH2)10 group to FmocNAAddition of HOOC-(CH2)10 group to Fmoc5LinearNANANANANANANAICR male mice10 micromole/KgIntraperitonealHot water tail flick testAnalgesic effect seen within 3 seconds NA NA NA NA Alzheimer NA NA NA 22778833
b3pdb_0146Fmoc-Leu-EnkephalinsYGGFLTyr-Gly-Gly-Phe-Leu-OHNANAEnd to end joining of two Fmoc-Leu-Enkephalin5LinearNANANANANANANAICR male mice10 micromole/KgIntraperitonealHot water tail flick testAnalgesic effect seen within 3.5 seconds NA NA NA NA Alzheimer NA NA NA 22778833
b3pdb_0147Goldnanoparticle conTHRPPMWSPVWPThrHisArgProProMetTrpSerProValTrpProNANAConjugated with CLPFFD goldnaNAparticle12LinearCationicChemically synthesizedNANANANANAAdult Sprague-Dawley rats1.86 mg/KgIntraperitonealInstrumental neutron activation analysis and Nissl stainingConjugate was found to cross blodd brain barrier; does not effect mice survival; no toxicity as meas NA NA NA NA Alzheimer NA NA NA 22795856
b3pdb_0148PACAP-TAT peptidePACAP-YGRKKRRQRRRPACAP-TyrGlyArgLysLysArgArgGlnArgArgArgNAConjugated with TATNANACyclicCationicNatural from pituitary glandNANANANANAMale NIH mouse100 nmol/KgIntraperitonealFluoroscent screening by FITC labbled peptide maass in brain tissuecrosses blood brain barrier with 6.55+/-0.55% efficacy NA NA NA NA Alzheimer NA NA NA 22939769
b3pdb_0149PACAP-TAT peptidePACAP-YGRKKRRQRRRPACAP-TyrGlyArgLysLysArgArgGlnArgArgArgNANANANACyclicCationicNatural from pituitary glandNANANANANAMale NIH mouse100 nmol/KgIntraperitonealFluoroscent screening by FITC labbled peptide maass in brain tissuecrosses blood brain barrier with 2.77+/-0.88% efficacy NA NA NA NA Alzheimer NA NA NA 22939769
b3pdb_0150MMP-2200Y-D-TGFLS(β-O-Glc)-CONH2Tyr-D-Thr-Gly-Phe-Leu-Ser(β-O-Glc)-CONH2NANAGlycosylated serine residue6LinearNAChemically synthesizedNANANANANAAdult Sprague-Dawley rats10mg/KgIntraperitonealMicrodialysis analysis and LCMS analysisSignificant amount of peptide crosses blood brain barrier after 12 minute and remain stable up to 80 Shows potent analgesic behaviour NA NA NA Parkinson Stability/half life 80 minute NA 23127847
b3pdb_1208Adiponetic peptideLQVYGDGDHNGLYADNVNNANANANA18LinearNANANANANANANAC57BL/6J mice15 mg/kg of APNpIntraperitonealFourier Transform Infrared SpectroscopyAPNp suppressed mitochondrial and ATF4-CHOP apoptosis pathways in a Smad3 dependent manner. NA Permeability NA Alone ICH injury in diabetic mice NA APNp promoted neural sur- vival following ICH injury in the diabetic setting, by suppressing mitocho NA 31922310
b3pdb_1218dNP2KIKKVKKKGRKGSKIKKVKKKGRKNANANANA24NACationicChemically synthesizedNAJurkat cells2 μMConfocal microscopydNP2 enables the delivery of LRR domain of NLRX1 into T cellsC57BL/6J MiceNAIntraperitonealConfocal microscopydNP2 enables the delivery of LRR domain of NLRX1 into T cells It directly inhibits the functions of effector T cells and ameliorates disease severity of EAE with NA NA Combined with LRR Encephalomyelitis NA NA NA 32194859