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G-Tic-Oic-K-Tic-Oic-G-Tic-Oic-K-Tic-KKKK details |
Primary information | |
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ID | antitb_1745, |
Name | US 2012/0197004 |
N-Terminal modification | FKAB-1Ge |
C-Terminal Modification | G-Tic-Oic-K-Tic-Oic-G-Tic-Oic-K-Tic-KKKK |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid |
Chirality | Linear |
Nature | 15 |
Source | L |
Origin | Hydrophobic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium ranae |
In Vitro/ In vivo | Mycobacterium ranae |
Cell Line | MIC = 3 μM |
Inhibition Concentration | Both |
Sequence | 2012 |
Cytotoxicity | RBC |
In vivo Model | NA |
Lethal Dose | 26.7 % hemolysis at 100 μM and 9.2 % at 25 μM |
Immune Responce | Mice |
Mechanism of Action | No observed toxicity at 1, 5 and 25 mg/kg |
Target | NA |
Combination Therapy | NA |
Other activities | NA |
PMID | None |
Year of Publication | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
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ID | antitb_1786, |
Name | 17547385 |
N-Terminal modification | Peptide-30 |
C-Terminal Modification | G-Tic-Oic-K-Tic-Oic-G-Tic-Oic-K-Tic-KKKK |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid |
Chirality | Linear |
Nature | 15 |
Source | L |
Origin | Amphipathic, Hydrophobic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium ranae |
In Vitro/ In vivo | Mycobacterium ranae (ATCC 110) |
Cell Line | MIC = 3 µM or 6 µg/mL |
Inhibition Concentration | Both |
Sequence | 2007 |
Cytotoxicity | RBC |
In vivo Model | NA |
Lethal Dose | 26.7 % and 9.2 % hemolytic activity at 100 µM and 25 µM peptide respectively |
Immune Responce | mouse skin wound healing model |
Mechanism of Action | No toxicity observed at 25 mg/kg for 6 days |
Target | Stimulate innate immune system |
Combination Therapy | NA |
Other activities | NA |
PMID | NA |
Year of Publication | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) |
Tertiary Structure (Technique) | Not Predicted), |