Primary information |
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ID | antitb_1786 |
Peptide Name | Peptide-30 |
Sequence | G-Tic-Oic-K-Tic-Oic-G-Tic-Oic-K-Tic-KKKK |
N-terminal Modification | Acetylation |
C-terminal Modification | Amidation |
Chemical Modification | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid |
Linear/ Cyclic | Linear |
Length | 15 |
Chirality | L |
Nature | Amphipathic, Hydrophobic |
Source | Synthetic |
Origin | NA |
Species | Mycobacterium ranae |
Strain | Mycobacterium ranae (ATCC 110) |
Inhibition Concentartion | MIC = 3 µM or 6 µg/mL |
In vitro/In vivo | Both |
Cell Line | RBC |
Inhibition Concentartion | NA |
Cytotoxicity | 26.7 % and 9.2 % hemolytic activity at 100 µM and 25 µM peptide respectively |
In vivo Model | mouse skin wound healing model |
Lethal Dose | No toxicity observed at 25 mg/kg for 6 days |
Immune Response | Stimulate innate immune system |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | NA |
Other Activities | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) |
Pubmed ID | 17547385 |
Year of Publication | 2007 |
3-D Structure | NA |