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Detailed description page of AntiTbPdb

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antitb_1157 details
Primary information
IDantitb_1157
Peptide NameNisin S
SequenceI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMS-(Abu)-A-(Abu)-ANASIHV-(Dha)-K
N-terminal ModificationFree
C-terminal ModificationFree
Chemical ModificationDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and Ala
Linear/ CyclicCyclic (5 hinge region dur to presence of lanthion
Length34
ChiralityL
NatureNA
SourceNatural
OriginProduced by Lactococcus lactis
SpeciesMycobacterium avium
StrainMycobacterium avium subsp. Hominissuis (CIT05/03)
Inhibition Concentartion28% reductions in growth, relative to that brought about by nisin A
In vitro/In vivoIn vitro
Cell LineNone
Inhibition ConcentartionNA
CytotoxicityNA
In vivo ModelNone
Lethal DoseNA
Immune ResponseNA
Mechanism of ActionNA
TargetNA
Combination TherapyNone
Other ActivitiesAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)
Pubmed ID21468208
Year of Publication2010
3-D StructureNA