Browse result page of AntiTbPdb
The total number entries retrieved from this search are 550
ID | Name | Sequence | N-Terminal Modification | C-Terminal Modification | Chemical Modification | Linear/Cyclic | Length | Chirality | Nature | Source | Origin | Species | Strain | Inhibition Concentration | In vitro/ In vivo | Cell Line | Intracellular Inhibition | Cytotoxicity | Animal Model | Effective Dose in model organism | Immune Responce | Mechanism of Action | Target | Combination Therapy | Other Activities | Year of Publication | Pubmed ID/ Patent No. |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
antitb_1656 | Trichoderins B | not available | NA | NA | NA | NA | 0 | NA | NA | Natural | Trichoderma species | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (aerobic) | IC90= 0.63 μg/ml | in vitro | Human THP-1 cell lines | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2010 | 20483615 |
antitb_1659 | Trichoderins B | not available | NA | NA | NA | NA | 0 | NA | NA | Natural | Trichoderma species | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (hypoxic) | IC90= 0.63 μg/ml | in vitro | Human THP-1 cell lines | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2010 | 20483615 |
antitb_1662 | Trichoderins B | not available | NA | NA | NA | NA | 0 | NA | NA | Natural | Trichoderma species | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (aerobic) | IC90= 0.02 μg/ml | in vitro | Human THP-1 cell lines | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2010 | 20483615 |
antitb_1665 | Trichoderins B | not available | NA | NA | NA | NA | 0 | NA | NA | Natural | Trichoderma species | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (hypoxic) | IC90= 0.02 μg/ml | in vitro | Human THP-1 cell lines | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2010 | 20483615 |
antitb_1668 | Trichoderins B | not available | NA | NA | NA | NA | 0 | NA | NA | Natural | Trichoderma species | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (aerobic) | IC90= 0.13 μg/ml | in vitro | Human THP-1 cell lines | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2010 | 20483615 |
antitb_1671 | Trichoderins B | not available | NA | NA | NA | NA | 0 | NA | NA | Natural | Trichoderma species | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (hypoxic) | IC90= 0.13 μg/ml | in vitro | Human THP-1 cell lines | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 2010 | 20483615 |
antitb_1679 | TL-119 | not available | NA | NA | None | NA | 0 | NA | NA | Natural | Bacillus species, strain TL-119 | Mycobacterium Tuberculosis | Mycobacterium tuberculosis H37Rv | MIC = >50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial against Bacillus subtilis PCI 219, Staphylococcus aureus FDA 209P JC-1, Staphylococcus aureus Smith, Diplococcus pneumoniae type I, Streptococcus pyogenes C-203, Escherichia coli NIHJ JC-2, Klebsiella pneumoniae, Salmonella typhimurium, Pseudomonas aeruginosa Ps 24 | 1974 | 1112764 |
antitb_1680 | 61-26 | not available | NA | NA | None | NA | 0 | NA | Weakly basic | Natural | Bacillus, strain 61-26, | Mycobacterium Tuberculosis | Mycobacterium tuberculosis H37Rv | MIC = >50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial against Bacillus subtilis PCI 219, Bacillus anthracis, Staphylococcus aureus FDA 209P JC-1, Staphylococcus aureus Smith, Diplococcus pneumoniae type I, Streptococcus pyogenes C-203, Escherichia coli NIHJ JC-2, Klebsiella pneumoniae, Salmonella typhimurium And Antifungal against Candida albicans M-9, Trichophyton rubrum, Trichophyton mentagrophytes | 1974 | 1112765 |
antitb_1683 | S35-Siomycin | not available | NA | NA | None | NA | 0 | NA | NA | Natural | Streptomyces sioyaensis | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | in vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | many clinical resistant strains of Staphylococcus | 1972 | 4630599 |
antitb_1684 | Jolipeptin | not available | NA | NA | None | NA | 0 | NA | NA | Natural | Bacillus polymyxa var. colistinus Koyama | Mycobacterium Tuberculosis | Mycobacterium tuberculosis 607 | MIC = 10 μg/mL | in vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial against E. coli B, E. coli NIHJ, Staphylococcus aureus FDA 209P, Bacillus subtilis PCI 219, Micrococcus lysodeihticus | 1972 | 5042449 |
antitb_1685 | S-520 | not available | NA | NA | None | NA | 0 | NA | NA | Natural | Streptomyces diastaticus | Mycobacterium Tuberculosis | Mycobacterium tuberculosis 607 | MIC = 100 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial against Bacillus subtilis, Bacillus anthracis, Staphylococcus aureus, Staphylococcus aureus,Streptococcus pyogenes,Diplococcus pneumoniae, Sarcinalutea Corynebacterium diphtheriae | 1970 | 5459623 |
antitb_1702 | Human neutrophil peptide (HNP-1) | ACYCRIPACIAGERRYGTCIYQGRLWAFCC | Free | Free | Disulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29 | Cyclic | 30 | L | Cationic | Natural | Human neutrophil | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 7632G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1703 | Human neutrophil peptide (HNP-1) | ACYCRIPACIAGERRYGTCIYQGRLWAFCC | Free | Free | Disulphide linkage between cys2-cys30, cys4-cys19,cys9-cys30 | Cyclic | 30 | L | Cationic | Natural | Human neutrophil | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 9034G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1704 | Human neutrophil peptide (HNP-1) | ACYCRIPACIAGERRYGTCIYQGRLWAFCC | Free | Free | Disulphide linkage between cys2-cys30, cys4-cys19,cys9-cys31 | Cyclic | 30 | L | Cationic | Natural | Human neutrophil | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 11170G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1705 | Synthetic rabbit neytrophil (SNP-1) | not available | NA | NA | NA | NA | 0 | NA | Cationic | Natural | Rabbit neutrophil | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 7632G | 5Reduction in CFU at 0 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1706 | Synthetic rabbit neytrophil (SNP-1) | not available | NA | NA | NA | NA | 0 | NA | Cationic | Natural | Rabbit neutrophil | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 9034G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1707 | Synthetic rabbit neytrophil (SNP-1) | not available | NA | NA | NA | NA | 0 | NA | Cationic | Natural | Rabbit neutrophil | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 11170G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1708 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 7632G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1709 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-14 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 9034G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1710 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-15 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 11170G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1711 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-16 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37 Ra | IC50= 5 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1712 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-17 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37 Ra | MIC = 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
antitb_1713 | Ecumicin | (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val) | Free | Free | N-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe | Macrocyclic | 13 | L | NA | Natural | Produced by a genetically distinct Nonomuraea species, strain MJM5123 | Mycobacterium tuberculosis | Mycobacterium Tuberculosis H37Rv resistant to streptomycin | IC90= < 0.20 μg/ml | Both | VERO cell line | 50 % bacteria is killed | No cytotoxicity | NA | NA | NA | NA | NA | NA | NA | 2014 | 25409285 |
antitb_1714 | Ecumicin | (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val) | Free | Free | N-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe | Macrocyclic | 13 | L | NA | Natural | Produced by a genetically distinct Nonomuraea species, strain MJM5124 | Mycobacterium tuberculosis | Mycobacterium Tuberculosis H37Rv resistant to rifampicin | IC90= 0.30 μg/ml | Both | VERO cell line | 51 % bacteria is killed | No cytotoxicity | NA | NA | NA | NA | NA | NA | NA | 2014 | 25409285 |
antitb_1715 | Ecumicin | (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val) | Free | Free | N-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe | Macrocyclic | 13 | L | NA | Natural | Produced by a genetically distinct Nonomuraea species, strain MJM5125 | Mycobacterium tuberculosis | Mycobacterium Tuberculosis H37Rv resistant to cycloserine | IC90= < 0.20μg/ml | Both | VERO cell line | 52 % bacteria is killed | No cytotoxicity | NA | NA | NA | NA | NA | NA | NA | 2014 | 25409285 |
antitb_1723 | SEQ ID NO 3 | NVTSIHSLL | Free | Free | None | Linear | 9 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1724 | SEQ ID NO 4 | ELNNALQNLART | Free | Free | None | Linear | 12 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1725 | SEQ ID NO 7 | SGSEAYQGVQQKWDA | Free | Free | None | Linear | 15 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1726 | SEQ ID NO 8 | TATELNNAL | Free | Free | None | Linear | 9 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1727 | SEQ ID NO 9 | RTISEAGQAM | Free | Free | None | Linear | 10 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1728 | SEQ ID NO 10 | AYQGVQQKW | Free | Free | None | Linear | 9 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1729 | SEQ ID NO 11 | SEAYQGVQQ | Free | Free | None | Linear | 9 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1730 | SEQ ID NO 12 | SEAYQGVQQK | Free | Free | None | Linear | 10 | L | NA | Protein Derived | From the proetins containing mycobacterial CD8 T cell epitopes | Mycobacterium tuberculosis | Mycobacterium tuberculosis | NA | In vitro | PBMcs | NA | NA | β2-microglobulin gene knowckout mice, TAP-1 null mutant mice and HSP-65 immunized mice | NA | IFN-γ release increases | By CD8 T cell response | NA | None | None | 2002 | US 2002/013197 |
antitb_1731 | Seq ID No 10 | KMHATNHGGGS | Free | Free | None | Linear | 11 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M13 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
antitb_1732 | Seq ID No 22 | YPHHFKHRHIPIGGGS | Free | Free | None | Linear | 16 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M14 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
antitb_1733 | Seq ID No 1 | GVENVSW | Free | Free | None | Linear | 7 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M15 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
antitb_1734 | Seq ID No 2 | KMHATNH | Free | Free | None | Linear | 7 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M16 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
antitb_1735 | Seq ID No 9 | KMHATNHGGGS | Free | Free | None | Linear | 11 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M17 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
antitb_1736 | Seq ID No 21 | YPHHFKHRHIPI | Free | Free | None | Linear | 12 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M18 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
antitb_1811 | LL- 37 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | Free | Free | None | Linear | 37 | L | Cationic | Natural | Human cells | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 5 μM | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1812 | mouse CRAMP | GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ | Free | Free | None | Linear | 34 | L | Cationic | Natural | Mouse cells | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 4 μM | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1813 | E2 (also known as Bac8c) | RIWVIWRR | Free | Amidation | None | Linear | 8 | L | Cationic | Synthetic | NA | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 2.6 ± 0.34 g/mL | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1814 | E6 (also called Sub3) | RRWRIVVIRVRR | Free | Amidation | None | Linear | 12 | L | Cationic | Synthetic | NA | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 3.2 ± 0.10 g/mL | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1815 | CP26 | KWKSFIKKLTSAAKKVVTTAKPLISS | Free | Free | None | Linear | 26 | L | Cationic | Protein Derived | derived from a hybrid peptide comprising the amphipathic α -helical Nterminal region of cecropin A and the hydrophobic N-terminal α-helix of the bee venom peptide melittin | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 2.1 ± 0.33 g/mL | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1832 | Hytramycin V | (METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip) | Free | Free | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties | Cyclic (Intrachain bond between 1-6) | 6 | Mix | NA | Natural | From Streptomyces hygroscopicus strain ECUM 14046 | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | MIC = 11.3 μg/mL | In vitro | None | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) | 2013 | 24224794 |
antitb_1833 | Hytramycin V | (METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip) | Free | Free | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties | Cyclic (Intrachain bond between 1-6) | 6 | Mix | NA | Natural | From Streptomyces hygroscopicus strain ECUM 14046 | Mycobacterium tuberculosis | Clinical isolate, X004439 | MIC = 9.3 μg/mL | In vitro | None | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) | 2013 | 24224794 |
antitb_1834 | Hytramycin V | (METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip) | Free | Free | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties | Cyclic (Intrachain bond between 1-6) | 6 | Mix | NA | Natural | From Streptomyces hygroscopicus strain ECUM 14046 | Mycobacterium tuberculosis | Clinical isolate, X004244 | MIC = 16.9 μg/mL | In vitro | None | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) | 2013 | 24224794 |
antitb_1835 | Hytramycin V | (METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip) | Free | Free | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties | Cyclic (Intrachain bond between 1-6) | 6 | Mix | NA | Natural | From Streptomyces hygroscopicus strain ECUM 14046 | Mycobacterium tuberculosis | Clinical isolate, X005282 | MIC = 9.6 μg/mL | In vitro | None | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) | 2013 | 24224794 |
antitb_1836 | Hytramycin V | (METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip) | Free | Free | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties | Cyclic (Intrachain bond between 1-6) | 6 | Mix | NA | Natural | From Streptomyces hygroscopicus strain ECUM 14046 | Mycobacterium tuberculosis | Clinical isolate, X005319 | MIC = 19.2 μg/mL | In vitro | None | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) | 2013 | 24224794 |
antitb_1837 | Hytramycin V | (METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip) | Free | Free | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties | Cyclic (Intrachain bond between 1-6) | 6 | Mix | NA | Natural | From Streptomyces hygroscopicus strain ECUM 14046 | Mycobacterium tuberculosis | Clinical isolate, X001354 | MIC = 9.7 μg/mL | In vitro | None | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) | 2013 | 24224794 |