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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 550
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1514Hirsutatins Anot availableFreeFreeNoneBranched cyclic0DCationicNaturalDerived from HirsutellaniveaMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC =50 mg/mlin vitroNANANANA NANANANANANA201525681127
antitb_1515Hirsutatins Bnot availableFreeFreeNoneBranched cyclic0DCationicNaturalDerived from HirsutellaniveaMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 50 mg/mlin vitroNANANANA NANANANANANA201525681127
antitb_1516PR-39RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFPFreeFreeNoneLinear39LCationicNaturalDerived from pig porcineMycobacterium tuberculosisMycobacterium tuberculosis H37RvReduction in growth is inhibited to to 30 % at conc. 6.25 mg/Lin vitroNANANANA NANANANANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1517PR-39RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFPFreeFreeNoneLinear39LCationicNaturalDerived from pig porcineMycobacterium tuberculosisMycobacterium tuberculosis H37RvReduction in growth is inhibited to to80% at conc. 50 mg/Lin vitroNANANANA NANANANANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1518PR-39RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFPFreeFreeNoneLinear39LCationicNaturalDerived from pig porcineMycobacterium tuberculosisMycobacterium tuberculosis H37RvIC50 = 17± 9 mg/Lin vitroNANANANA NANANANANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1519PR-39RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFPFreeFreeNoneLinear39LCationicNaturalDerived from pig porcineMycobacterium tuberculosisMycobacterium tuberculosis E1380/94 (MDR resistant stain)IC50= 93± 12 mg/Lin vitroNANANANA NANANANANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1521PR-39RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFPFreeFreeNoneLinear39LCationicNaturalDerived from pig porcineMycobacterium tuberculosisMycobacterium tuberculosis H37RvIC50= 50 mg/Lin vitroNANANANA NANANANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1522PR-39RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFPFreeFreeNoneLinear39LCationicNaturalDerived from pig porcineMycobacterium tuberculosisMycobacterium tuberculosis E1380/94 (MDR resistant stain)IC50= 50 mg/Lin vitroNANANANA NANANANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1524NK-LysinNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDFreeFreeNoneLinear36LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosis H37RvReduction in bacterial growth inhibiton to 60% at conc. Of 9.37 mg/Lin vitroNANANANA NANAInteacting with microbial membraneNANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1525N22VCEHIHLIRGLCHHLMHSYIKRFreeFreeNoneLinear21LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosis H37RvReduction in bacterial growth inhibiton to 59% at conc. Of 50 mg/L in vitroNANALow toxicity to erythrocyteNA NAInteacting with microbial membraneNANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1526NKLF2VCDKMKILRGVCKKIMRSFLRRFreeFreeNoneLinear21LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANANA NAInteacting with microbial membraneNANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1527Human neutrohil peptide (HNP-1)ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29cyclic30LCationicSyntheticHuman neutrophil Mycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANANA NAInteacting with microbial membraneNANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525681127
antitb_1528LL-37LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTESFreeFreeNoneLinear37LCationicProtein derivedDerived from Human cationic antimicrobial protein 18 (hCAP18)Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 2.1 μg/mlin vitroHuman macrophage THP1NANo cytotoxicityC57BL/6 Mice NAInduce expression of IL-8 and MCP-1In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteriaBacterial cell membrane NANA201525613372
antitb_1529LLKKK-18KEFKRIVKRIKKFLRKLVFreeFreeNoneLinear18LCationicProtein derivedDerived from Human cationic antimicrobial protein 18 (hCAP18)Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 25 μg/mlin vitroHuman macrophage THP1NANo cytotoxicityNA NAInduce expression of IL-8 and MCP-1In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteriaBacterial cell membrane NANA201525613372
antitb_1530D5KWKSFLKTFKSLKKTKLHTLLKLISSAcetylationAmidationNoneLinear27LCationicProtein derivedDerived from Human cationic antimicrobial protein 18 (hCAP18)Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 35.2 μg/mlin vitroHuman macrophage THP1NANo cytotoxicityNA NAInduce expression of IL-8and MCP-1In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteriaBacterial cell membrane NANA201525613372
antitb_1531D5KWKSFLKTFKSLKKTKLHTLLKLISSAcetylationAmidationNoneLinear27LCationicProtein derivedDerived from Human cationic antimicrobial protein 18 (hCAP18)Mycobacterium tuberculosisMycobacterium tuberculosis MDR-TBMIC = 49 μg/mlin vitroHuman macrophage THP1NANo cytotoxicityNA NAInduce expression of IL-8and MCP-1In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteriaBacterial cell membrane NANA201525613372
antitb_1532G13QRSVSNAATRVCRTGRSRWFreeFreeNoneLinear19LCationicProtein derivedDerived from human granulysin proteinMycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANo cytotoxicityNA NANANANANANA201525613372
antitb_1533GranF2VCRTGRSRWRDVNRNFMRRYQSRFreeFreeNoneLinear23LCationicProtein derivedDerived from human granulysin proteinMycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANo cytotoxicityNA NANANANANANA201525613372
antitb_1534ProregionSVFPQQTTGQLAELQPQDRAGARASWMPMFQRRRRRFreeFreeNoneLinear36LCationicProtein derivedDerived from Hepcidin proteinMycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANANA NAinduce expression of IFN-γ Cause structural damage to mycobacteriaNANANA201525613372
antitb_1535Human neutrohil peptide (HNP-1)DCYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29Cyclic30LCationicNaturalHuman neutrophil Mycobacterium tuberculosisMycobacterium tuberculosis H37Rv2.5 μg/mlin vitroNANANo cytotoxicityNA NAMediate macrophage to induce TNF-α expression Inhibit lipid biosynthesiNANAAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525613372
antitb_1536Human neutrohil peptide (HNP-1)DCYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29Cyclic30LCationicNaturalHuman neutrophil Mycobacterium tuberculosisMycobacterium tuberculosis H37RvIC50=0.0375 μg/mlin vitroNANANANA NAMediate macrophage to induce TNF-α expression Inhibit lipid biosynthesiNAHNP-1 + RifampicinAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525613372
antitb_1537Human neutrohil peptide (HNP-1)DCYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29Cyclic30LCationicNaturalHuman neutrophil Mycobacterium tuberculosisMycobacterium tuberculosis H37RvIC50= 0.0255 μg/mlin vitroNANANANA NAMediate macrophage to induce TNF-α expression Inhibit lipid biosynthesiNAHNP-1 + IsoniazidAntibacterial against E.coli, S.aureus, bacillus, pseudomonas201525613372
antitb_1538HCL2ESTYQGHHTPPVQKGLRYGIILFITSEVFFFAGFFFreeFreeNoneLinear35LCationicProtein derivedDerived from Cytochrome C oxidase subunit 3Mycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroHuman macrophage THP1NANo cytotoxicityNA NANADisrupt interaction between ESAT-6 and CFP10 bacterial ESAT-6NANA201525613372
antitb_1539MIAPGIGKFLKSKGKFGKAFreeFreeNoneLinear15LCationicNANAMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 300 μg/mlin vitroNANANANA NANANANANANA201525613372
antitb_1540Ub2STLHLVLRLRGGFreeFreeNoneLinear12LCationicProtein derivedDerived from human ubiquitin proteinMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 5 μg/mlin vitroNANANANA NANADisrupt the mycobacterial membraneNANABactericidal against pseudomonas and staphylococcus at pH 5.5201525613372
antitb_1541RNase3RPPQFTRAQWFAIQHISLMPPRCTIAMRAINNYRWRCKNQNTFLRFreeFreeNoneLinear45LCationicProtein derivedDerived from eisinophilic cationic protein (ECP) Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 20 μg/mlin vitroNANANANA NANADisrupt the mycobacterial membraneNANABactericidal against pseudomonas and staphylococcus at pH 5.5201525613372
antitb_1542RNAse7RPPQFTRAQWFAIQHISLMPPRCTIAMRAINNYRWRCKNQNTFLRFreeFreeNoneLinear45LCationicProtein derivedDerived from eisinophilic cationic protein (ECP) Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 10 μg/mlin vitroNANANANA NANADisrupt the mycobacterial membraneNANABactericidal against pseudomonas and staphylococcus at pH 5.5201525613372
antitb_1544HepcidinDTHFPICIFCCGCCHRSKCGMCCKTFreeFreeNoneLinear25LCationicProtein derivedDerived from Hepcidin proteinMycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANANA NAinduce expression of IFN-γ Cause structural damage to mycobacteriaNANANA201525613372
antitb_1545D-LFcin17-30FKCRRWQWRMKKLGFreeFreeNoneLinear14LCationicNANAMycobacterium tuberculosisMycobacterium tuberculosis H37Rv14.4 μg/mlin vitroNANANANA NAinduce expression of IFN-γ Cause structural damage to mycobacteriaNANANA201525613372
antitb_1546LassomycinGLRRLFADQLVGRRNFreeMethylationFree NH- group of first Glycine form NHCO bond with CO group of eight Asparagine to form cyclic bond Cyclic15DCationicNaturalDerived from lentzea kentuckyensisMycobacterium tuberculosisMycobacterium tuberculosis H37RvIC50 = 0.8-3 mg/mlin vitroNANANANA NANANANANANA201525613372
antitb_1547LassomycinGLRRLFADQLVGRRNFreeMethylationFree NH- group of first Glycine form NHCO bond with CO group of eight Asparagine to form cyclic bond Cyclic15DCationicNaturalDerived from lentzea kentuckyensisMycobacterium tuberculosisMycobacterium tuberculosis MDRIC50= 0.8-3 mg/mlin vitroNANANANA NANANANANANA201525613372
antitb_1548LassomycinGLRRLFADQLVGRRNFreeMethylationFree NH- group of first Glycine form NHCO bond with CO group of eight Asparagine to form cyclic bond Cyclic15DCationicNaturalDerived from lentzea kentuckyensisMycobacterium tuberculosisMycobacterium tuberculosis XDRIC50= 0.8-3 mg/mlin vitroNANANANA NANANANANANA201525613372
antitb_1549NisinAI-(Dhb)-A-I-D-L-A-(Dha)-P-G-A-K-(Abu)-G-A-L-M-G-A-N-M-K-(Abu)-A-(Abu)-A-N-S-I-H-V-(Dha)-LFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acidLinear33LCationicNANAMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 60 μg/mlin vitroNANANANA NANANANANANA201525613372
antitb_1550Lacticin 3147AA-(Dhb)-N-(Dhb)-FALADYWGNNGAWA-(Abu)-L-(Abu)-HEAMAWAKFreeFreeDhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acidLinear30LCationicNaturalDerived from Lactococcus lactisMycobacterium tuberculosisMycobacterium tuberculosis H37RaIC90= 7.5 μg/mlin vitroNANANANA NANANANANANA201525613372
antitb_1553E50-52TTKNYGNGVCNSVNWCQCGNVWASCNLATGCAAWLCKLAFreeFreeNoneLinear39LCationicNaturalDerived from Enterococcus faecalisMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC= 0.1mg/L (within macrophage)in vitro NANANANA NANANANANANA201525613372
antitb_1554E50-52TTKNYGNGVCNSVNWCQCGNVWASCNLATGCAAWLCKLAFreeFreeNoneLinear39LCationicNaturalDerived from Enterococcus faecalisMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 1μg/mlin vitroNANANANA NANANANANANA201525613372
antitb_1555Pk34PRVIETKVHGREVTGLARNVSEENVDRLAKRWIKFreeFreeNoneLinear34LCationicMycobacteriophage derivedDerived from mycobacteriophage Mycobacterium tuberculosisMycobacterium tuberculosis H37RvIC50= 50 μg/mlin vitroNANAMacrophage like J774A.1 cell lineBALB/C mice 20mg/KgIncrease production of cytokine like IFN-γ,TNF-α,IL-12,MCp-1, IL-10, IL-6 NANANABactericidal against E.coli, pseudomonas, S.aureus, Bacillus subtilis201525613372
antitb_15561-C134merH-Ntridec-Nlys-Nspe-Nspe-Nlys_NH2FreeAmidationNlys = N-(4-aminobutyl)glycine, Nssb = (S)-N-(sec-butyl)glycineNA5LCationicNANAMycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 6.3 μg/mlNANANANANA NANANANANANA201525613372
antitb_1557Vgf-1ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGGFreeFreeNoneLinear59LNANaturalDerived from snake venom N.atraMycobacterium tuberculosisMycobacterium tuberculosis H37Rv ATCC25618 (resistant to INH) DR-iMIC = 8.5 ± 0.1 mg/Lin vitroNANANANA NANANANANANA200312927960
antitb_1558Vgf-1ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGGFreeFreeNoneLinear59LNANaturalDerived from snake venom N.atraMycobacterium tuberculosisMycobacterium tuberculosis H37Rv ATCC25618 (resistant to INH+Rif) DR-irMIC = 8.5 ± 0.1 mg/Lin vitroNANANANA NANANANANANA200412927960
antitb_1559Vgf-1ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGGFreeFreeNoneLinear59LNANaturalDerived from snake venom N.atraMycobacterium tuberculosisMycobacterium tuberculosis H37Rv ATCC25618 (resistant to INH+Streptomycin) DR-isMIC = 8.5 ± 0.1 mg/Lin vitroNANANANA NANANANANANA200512927960
antitb_1560Vgf-1ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGGFreeFreeNoneLinear59LNANaturalDerived from snake venom N.atraMycobacterium tuberculosisMycobacterium tuberculosis H37Rv ATCC25618 (resistant to INH+Streptomycin) DR-isMIC = 8.5 ± 0.1 mg/Lin vitroNANANANA NANANANANANA200612927960
antitb_1561Vgf-1ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGGFreeFreeNoneLinear59LNANaturalDerived from snake venom N.atraMycobacterium tuberculosisMycobacterium tuberculosis H37Rv ATCC25618 (resistant to INH+Rif+Streptomycin) DR-irsMIC = 8.5 ± 0.1 mg/Lin vitroNANANANA NANANANANANA200712927960
antitb_1562Vgf-1ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGGFreeFreeNoneLinear59LNANaturalDerived from snake venom N.atraMycobacterium tuberculosisMycobacterium tuberculosis H37Rv ATCC25618 (resistant to INH+Rif+Streptomycin+ehambutol) DR-irseMIC = 8.5 ± 0.1 mg/Lin vitroNANANANA NANANANANANA200812927960
antitb_1563Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.20 ± 0.15 at peptide concentration 64μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1564Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 2.70 ± 0.15 at peptide concentration 64μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1565Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 0.88± 0.30 at peptide concentration 4 μg/ml +INH 0.06 μg/mlin vitroNANANANA NANABacterial membrane pore formationNAINH +peptideNA200415245864
antitb_1566Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.19 ± 0.15 at peptide concentration 64 μg/ml +INH 0.06 μg/mlin vitroNANANANA NANABacterial membrane pore formationNAINH+PeptideNA200415245864
antitb_1567Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.19 ± 0.15 at peptide concentration 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1568Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.58 ± 0.47 at peptide concentration 8 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864