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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 550
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1295Trichoderins A (MDA)-P-(AHMOD)-(Aib)-(Aib)-I-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 0.12 μg/mLIn vitroNoneNANANone NANANANANoneNone201020483615
antitb_1298Trichoderins A1 (MDA)-P-(AMOD)-(Aib)-(Aib)-I-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AMOD = 2-amino-4-methy1-8-oxodec-6-enoic acid, Aib = a-amino- isobutyric acid, Linear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 2.0 μg/mLIn vitroNoneNANANone NANANANANoneNone201020483615
antitb_1301Trichoderins B (MDA)-P-(AHMOD)-(Aib)-(Aib)-V-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 0.13 μg/mLIn vitroNoneNANANone NANANANANoneNone201220483615
antitb_1306D-(V13K) D1KWKSFLKTFKSAKKTVLHTALKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 70.7 μg/mLIn vitroHuman erythrocyteNAHC50 = 421.5 μg/mLNA NANANANANANA201120858205
antitb_1307D-(V13K,A20L) D2KWKSFLKTFKSAKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 83.7 μg/mLIn vitroHuman erythrocyteNAHC50 = 83 μg/mLNA NANANANANANA201120858205
antitb_1308D-(V13K,A12L,A20L) D3KWKSFLKTFKSLKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 109.2 μg/mLIn vitroHuman erythrocyteNAHC50 = 14 μg/mLNA NANANANANANA201120858205
antitb_1309D-(V13K,A12L,A20L,A23L) D4KWKSFLKTFKSLKKTVLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 200 μg/mLIn vitroHuman erythrocyteNAHC50 = 3.5 μg/mLNA NANANANANANA201120858205
antitb_1310D-(V13K,A12L,A20L,A23L,V16K) D5KWKSFLKTFKSLKKTKLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 35.2 μg/mLIn vitroHuman erythrocyteNAHC50 = 47 μg/mLNA NANANANANANA201120858205
antitb_1311D-(V13K) D1KWKSFLKTFKSAKKTVLHTALKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 57 μg/mLIn vitroHuman erythrocyteNAHC50 = 7.4 μg/mLNA NANANANANANA201120858205
antitb_1312D-(V13K,A20L) D2KWKSFLKTFKSAKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 72 μg/mLIn vitroHuman erythrocyteNAHC50 = 12 μg/mLNA NANANANANANA201120858205
antitb_1313D-(V13K,A12L,A20L) D3KWKSFLKTFKSLKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 100 μg/mLIn vitroHuman erythrocyteNAHC50 = 0.14 μg/mLNA NANANANANANA201120858205
antitb_1314D-(V13K,A12L,A20L,A23L) D4KWKSFLKTFKSLKKTVLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = Ie μg/mL(inactive)In vitroHuman erythrocyteNAHC50 = Ie μg/mL(inactive)NA NANANANANANA201120858205
antitb_1315D-(V13K,A12L,A20L,A23L,V16K) D5KWKSFLKTFKSLKKTKLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 49 μg/mLIn vitroHuman erythrocyteNAHC50 = 1.0 μg/mLNA NANANANANANA201120858205
antitb_1316L-LL37LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNFreeFreeNoneLinear31LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = Ie μg/mL(inactive)In vitroHuman erythrocyteNAHC50 = 43.5 μg/mLNA NANANANANANA201120858205
antitb_1317D-LL37LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNFreeFreeNoneLinear31DCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 200 μg/mLIn vitroHuman erythrocyteNAHC50 = 125 μg/mLNA NANANANANANA201120858205
antitb_1318Peptoid 1 H-(NLys-Nspe-Nspe)4-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 14.1μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 14.1μMNA NANANANANANA201121464254
antitb_13191-C134mer H-Ntridec-NLys-Nspe-Nspe-NLys-NH2FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycine, Ntridec = N-(tridecyl)glycineLinear5LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 6.6 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = >100 μMNA NANANANANANA201121464254
antitb_132014merH-NLys-Nspe-Nspe-NLys-NH2FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear4LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvNAIn vitroRaw 264.7 and J774 mouse macrophageNANon toxicNA NANANANANANA201121464254
antitb_13211-Pro9 H-(NLys-Nspe-Nspe)2-NLys-Nspe-L-Pro-NLys-Nspe-Nspe-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 14.5 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 50 μMNA NANANANANANA201121464254
antitb_13221-11mer H-(NLys-Nspe-Nspe)3-NLys-Nspe-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear11LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 14.46 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 50μMNA NANANANANANA201121464254
antitb_13231-Nssb H-(NLys-Nssb-Nssb)4-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nssb = (S)-N-(sec-butyl)glycineLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = >100 μMIn vitroRaw 264.7 and J774 mouse macrophageNANon toxicNA NANANANANANA201121464254
antitb_1331Innate defence regulator peptide HH2VQLRIRVAVIRA FreeFreeNoneLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvNABothHuman U937 promonocytic cell line NANoneBALB/C 32 mg in 100 mL of saline solution (1 mg/kg) Increase expression of MCP-1,Gro-α and TNF-αNANANAAntimicrobial against plasmodium aeruginosa/ S. aureus201223555622
antitb_1332Innate defence regulator peptide 1002VQRWLIVWRIRK FreeFreeNoneLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 29.3 ± 11.8 mg/mLBothHuman U937 promonocytic cell line NANoneBALB/C 32 mg in 100 mL of saline solution (1 mg/kg) Increase expression of MCP-1,Gro-α and TNF-αNANANAAntimicrobial against plasmodium aeruginosa/ S. aureus201223555622
antitb_1333Innate defence regulator peptide 1018VRLIVAVRIWRR FreeFreeNoneLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 16.4± 5.4 mg/mL BothHuman U937 promonocytic cell line NANoneBALB/C 32 mg in 100 mL of saline solution (1 mg/kg) Increase expression of MCP-1,Gro-α and TNF-αNANANAAntimicrobial against plasmodium aeruginosa/ S. aureus201223555622
antitb_1334Cairomycin Bnot availableNANANACyclic0MixNANaturalStreptomyces fungusMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC= 50 μg/mL BothNANANASwiss mice 3 mg/kg of body weightNANANANAAntimicrobial against S.aureus, B.subtilis, P.aureginosa,Pseudomonas. Antifungal also.1976855995
antitb_1335Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium tuberculosis Mycobacterium tuberculosis H37RvIC50 = <0.0125 μg/mL (50%)BothNANANAICR/JCL male mice and male beagle dogs 10 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1338Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium tuberculosis Mycobacterium tuberculosis H37RvIC90= 0.05 μg/mL(90%)BothNANANAICR/JCL male mice and male beagle dogs 13 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1342Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium tuberculosis Mycobacterium tuberculosis R-KMNABothNANANAICR/JCL Mice 15 mg/kg for mice and 50mg/kg for dogNANANA4mg of DHMPA peptide+ 0.1 mg of IsoniazidNA19883348603
antitb_1354Nk-lysinNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDFreeFreeInternal disuphide bond 13 -23Cyclic37LNANaturalPig cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25618IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA30 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1355NKLF1VTQAASRVCDKMKILRGVCKKIMRTFLRRFreeFreeInternal disulphide bond at residue between 9-13Cyclic29LNANaturalPig cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25619IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA31 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1356NKLF2VCDKMKILRGVCKKIMRTFLRRFreeFreeNoneCyclic22LNANaturalPig cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25620IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA32 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1357Gran F2VCRTGRSRWRDVCRNFMRRYQSRFreeFreeInternal disulphide bond at residue between 2-13Cyclic23LNANaturalHuman cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25621IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA33 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1358Gran F1VSNAATRVCRTGRSRWRDVCRNFMRRYQSRFreeFreeNoneLinear30LNANaturalHuman cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25622IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA34 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1359GranulysinTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGFreeFreeNoneLinear38LNANaturalHuman cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25623IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA35 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1362Thymus peptidenot availableNANANoneNA0NANANaturalcalf thymusMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 300 μg/mlIn vitroNoneNANANA NANANANANANA195313118063
antitb_1369Thymus peptidenot availableNANANoneNA0NANANaturalCalf thymusMycobacterium tuberculiiMycobacterium tuberculii BCG-PhippsMIC = 100 μg/mLIn vitroNoneNANANA NANANANANANA195313118063
antitb_1370Human neutrophil peptides-1 ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29cyclic30LCationicSyntheticHuman neutrophilsMycobacterium tuberculosisMycobacterium tuberculosis H37 RaNAin vitroNoneNANANA NANANAMycobacterial genomic DNANAantibacterial against candida albicans200011375668
antitb_1371Mycobacterial tuberculosis DHFR tripeptide analogWYDFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.26 × 10−7in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1372Mycobacterial tuberculosis DHFR tripeptide analogWYEFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 5.02 × 10−6 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1373Mycobacterial tuberculosis DHFR tripeptide analogWPDFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 9.12 × 10−9 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1374Mycobacterial tuberculosis DHFR tripeptide analogWPEFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.02 × 10−6 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1375Mycobacterial tuberculosis DHFR tripeptide analogYPDFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 4.17 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1376Mycobacterial tuberculosis DHFR tripeptide analogYPEFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 2.75 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1377Mycobacterial tuberculosis DHFR tripeptide analogWYYFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.78 × 10−9 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1378Mycobacterial tuberculosis DHFR tripeptide analogWPYFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 9.55 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1379Mycobacterial tuberculosis DHFR tripeptide analogWYPFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 4.57 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1380Mycobacterial tuberculosis DHFR tripeptide analogWPWFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 4.27 × 10−6 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1381Mycobacterial tuberculosis DHFR tripeptide analogWYWFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.45 × 10−7 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1382Mycobacterial tuberculosis DHFR tripeptide analogWYSFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.44 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1383Mycobacterial tuberculosis DHFR tripeptide analogWPSFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 7.94 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148