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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 90
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1002Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis strain H37Rv (ATCC 27294) MIC = 0.16 μMBothVero cells (ATCC CRL-1586), J774.1 macrophage cell line, Caco-2 cell monolayers0.12 μM, ecumicin reduced M. tuberculosis viabilities in J774 macrophages by 2 x log10>63 μM for vero cells Female BALB/c mice, male CD-1 mice 20 mg/kg causes reductions in M. tuberculosis lungNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex Ecumicin encapsulated in micelles distributes to mouse lung tissue NA201525421483
antitb_1003Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis strain H37Rv (ATCC 27294) MIC = 0.16 μMBothVero cells (ATCC CRL-1586), J774.1 macrophage cell line, Caco-2 cell monolayers0.12 μM, ecumicin reduced M. tuberculosis viabilities in J774 macrophages by 2 x log10>63 μM for vero cells Female BALB/c mice, male CD-1 mice 32 mg/kg reductions in M. tuberculosis lung CFU 1.NAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex Ecumicin encapsulated in micelles distributes to mouse lung tissue NA201525421483
antitb_1004Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis strain H37Rv (ATCC 27294) MIC = 0.16 μMBothVero cells (ATCC CRL-1586), J774.1 macrophage cell line, Caco-2 cell monolayers0.12 μM, ecumicin reduced M. tuberculosis viabilities in J774 macrophages by 2 x log10>63 μM for vero cells Female BALB/c mice, male CD-1 mice Complete inhibition of M. tuberculosis growth in tNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex Ecumicin encapsulated in micelles distributes to mouse lung tissue NA201525421483
antitb_1005Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis Erdman (ATCC 35801) MIC = 0.16 μMBothJ774.1 macrophage cell line0.12 μM, ecumicin reduced M. tuberculosis viabilities in J774 macrophages by 2 x log10 >63 μM for J774.1 cellsFemale BALB/c mice, male CD-1 mice 20 mg/kg causes reductions in M. tuberculosis lungNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex Ecumicin encapsulated in micelles distributes to mouse lung tissue NA201525421483
antitb_1006Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis Erdman (ATCC 35801) MIC = 0.16 μMBothJ774.1 macrophage cell line0.12 μM, ecumicin reduced M. tuberculosis viabilities in J774 macrophages by 2 x log10>63 μM for J774.1 cellsFemale BALB/c mice, male CD-1 mice 32 mg/kg reductions in M. tuberculosis lung CFU 1.NAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex Ecumicin encapsulated in micelles distributes to mouse lung tissue NA201525421483
antitb_1007Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv strains with monoresistance to isoniazid (INH) (ATCC 35822) MIC <0.12 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1008Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv strains with monoresistance to rifampin (RMP) (ATCC 35838)MIC = 0.19 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1009Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv strains with monoresistance to streptomycin (SM) (ATCC 35820), MIC <0.12 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1010Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv strains with monoresistance to cycloserine (CS) (ATCC 35826)MIC = <0.12 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1011Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv strains with monoresistance to moxifloxacin (MFX)MIC = 0.31 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1012Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv strains with monoresistance to capreomycin (CAP)MIC = 0.29 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1013Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium smegmatis Mycobacterium smegmatis (ATCC 700084) MIC = 1.7 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1014Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium chelonaeMycobacterium chelonae (ATCC 35752) MIC = 0.97 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1015Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium marinumMycobacterium marinum (ATCC 927) MIC = 0.95 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1016Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium abscessusMycobacterium abscessus (ATCC 19977) MIC >63 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1017Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium aviumMycobacterium avium (ATCC 15769) MIC = 0.35 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1018Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium kansasiiMycobacterium kansasii (ATCC 12478) MIC = <0.24 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1019Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Mycobaterium tuberculosis MDRMIC = 0.31 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1020Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosisMycobaterium tuberculosis XDRMIC = 0.31–0.62 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1021Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Single nucleotide polymorphism (SNP) clusters: X001354 corresponding to the Indo-Oceanic lineage,MIC = 0.13–0.38 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1022Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Single nucleotide polymorphism (SNP) clusters: X004439 and X004244 to the East Asian lineageMIC = 0.13–0.38 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1023Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Single nucleotide polymorphism (SNP) clusters: X005282 and X005319 to the Euro-American lineageMIC = 0.13–0.38 μM In vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1024Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium tuberculosis Single nucleotide polymorphism (SNP) clusters: X001354 to the East African Indian lineageMIC = 0.13–0.38 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1144Nisin AI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region due to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium smegmatisMycobacterium smegmatis mc2155 NAIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1145Nisin AI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region due to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium tuberculosisMycobacterium tuberculosis H37Ra NAIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1146Nisin AI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region due to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium kansasiiMycobacterium kansasii CIT11/06 NAIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1147Nisin AI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region due to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium subsp. Hominissuis (CIT05/03)NAIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1148Nisin AI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region due to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium paratuberculosis (ATCC 19698) NAIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1149Nisin VI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANVK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium smegmatisMycobacterium smegmatis MC2155 2.2 mm zone of activity as compared to Nisin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1150Nisin VI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANVK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium tuberculosisMycobacterium tuberculosis H37Ra 10% decrease in relative growth as compared to Nicin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1151Nisin VI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANVK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium kansasiiMycobacterium kansasii CIT11/06 20% decrease in relative growth as compared to Nicin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1152Nisin VI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANVK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium subsp. Hominissuis (CIT05/03)16% decrease in relative growth as compared to Nicin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1153Nisin VI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANVK-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium paratuberculosis (ATCC 19698) 23% decrease in relative growth as compared to Nicin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1154Nisin SI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMS-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium smegmatisMycobacterium smegmatis MC2155 4 mm zone of activity as compared to Nisin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1155Nisin SI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMS-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium tuberculosisMycobacterium tuberculosis H37Ra 26% reductions in growth, relative to that brought about by nisin A In vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1156Nisin SI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMS-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium kansasiiMycobacterium kansasii CIT11/06 Relative growth was reduced by 29% compared to that which occurred in the presence of nisin A.In vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1157Nisin SI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMS-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium subsp. Hominissuis (CIT05/03)28% reductions in growth, relative to that brought about by nisin A In vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1158Nisin SI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMS-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium paratuberculosis (ATCC 19698) 19% decrease in growth as compare to the presence of Nicin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1159Nisin TI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMT-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium smegmatisMycobacterium smegmatis MC2155 2.7 mm zone of activity as compared to Nisin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1160Nisin TI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMT-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium tuberculosisMycobacterium tuberculosis H37Ra 24% more inhibition as compared to nisin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1161Nisin TI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMT-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium kansasiiMycobacterium kansasii CIT11/06 24% more inhibition as compared to nisin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1162Nisin TI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMT-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium subsp. Hominissuis (CIT05/03)16% more inhibition as compared to nisin AIn vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1163Nisin TI-(Dhb)-AI-(Dha)-LA-(Abu)-PGAK-(Abu)-GALMGANMT-(Abu)-A-(Abu)-ANASIHV-(Dha)-KFreeFreeDha= Didehydroalanine, Dhb= Didehydroaminobutyric acid, Abu= 2-aminobutyric acid, Lanthionine (Ala-S-Ala) formation from 3-7 Ala, and β-methyllanthionine (Abu-S-Ala) from 8-11, 13-19, 23-26, 25-28 in between Abu and AlaCyclic (5 hinge region dur to presence of lanthion34LNANaturalProduced by Lactococcus lactis Mycobacterium aviumMycobacterium avium paratuberculosis (ATCC 19698) 27% decrease in growth relative to nisin A In vitroNoneNANANone NANANANANoneAntibacterial (Shigella, Pseudomonas and Salmonella, S. aureus, S. agalactiae and L. monocytogenes)201021468208
antitb_1293Trichoderins A (MDA)-P-(AHMOD)-(Aib)-(Aib)-I-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium smegmatis Mycobacterium smegmatis MIC = 0.1 μg/mLIn vitroNoneNANANone NANANANANoneNone201020483615
antitb_1294Trichoderins A (MDA)-P-(AHMOD)-(Aib)-(Aib)-I-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium bovis Mycobacterium bovis BCGMIC =0.02 μg/mLIn vitroNoneNANANone NANANANANoneNone201020483615
antitb_1295Trichoderins A (MDA)-P-(AHMOD)-(Aib)-(Aib)-I-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 0.12 μg/mLIn vitroNoneNANANone NANANANANoneNone201020483615
antitb_1299Trichoderins B (MDA)-P-(AHMOD)-(Aib)-(Aib)-V-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium smegmatis Mycobacterium smegmatis MIC =0.63 μg/mLIn vitroNoneNANANone NANANANANoneNone201020483615
antitb_1300Trichoderins B (MDA)-P-(AHMOD)-(Aib)-(Aib)-V-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium bovis Mycobacterium bovis BCGMIC = 0.02 μg/mLIn vitroNoneNANANone NANANANANoneNone201120483615
antitb_1301Trichoderins B (MDA)-P-(AHMOD)-(Aib)-(Aib)-V-V-(Aib)-(Aib)-(AMAE)Addition of MDA = 2-methyl decanoic acid.Addition of AMAE = 2-[(20-aminopropyl) methylamino] ethanol.AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid, Aib = α-amino- isobutyric acidLinear8LNANaturalIsolated from a culture of marine sponge derived fungus of Trichoderma sp. Mycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 0.13 μg/mLIn vitroNoneNANANone NANANANANoneNone201220483615
antitb_1713Ecumicin(N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic 13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123Mycobacterium tuberculosis Mycobacterium Tuberculosis H37Rv resistant to streptomycinIC90= < 0.20 μg/mlBothVERO cell line50 % bacteria is killed No cytotoxicityNA NANANANANANA201425409285