Browse result page of AntiTbPdb
The total number entries retrieved from this search are 7
ID | Name | Sequence | N-Terminal Modification | C-Terminal Modification | Chemical Modification | Linear/Cyclic | Length | Chirality | Nature | Source | Origin | Species | Strain | Inhibition Concentration | In vitro/ In vivo | Cell Line | Intracellular Inhibition | Cytotoxicity | Animal Model | Effective Dose in model organism | Immune Responce | Mechanism of Action | Target | Combination Therapy | Other Activities | Year of Publication | Pubmed ID/ Patent No. |
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antitb_1001 | Polydim-I | AVAGEKLWLLPHLLKMLLTPTP | Free | Free | None | Linear | 22 | L | Amphipathic | Natural | Isolated from the venom of the Neotropical wasp Polybia dimorpha | Mycobacterium abscessus subsp. massiliense | Mycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus) | MIC = 60.8 μg/mL | Both | Peritoneal macrophages, J774 macrophages cells, human red blood cells | Treatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load | Non-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity | 6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice | 2 mg/kg/mLW shows 90% reduction in bacterial load | NA | Cell wall disruption | Cell wall | None | NA | 2016 | 26930596 |
antitb_1016 | Ecumicin | (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val) | Free | Free | N-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe | Macrocyclic | 13 | L | NA | Natural | Produced by a genetically distinct Nonomuraea species, strain MJM5123. | Mycobacterium abscessus | Mycobacterium abscessus (ATCC 19977) | MIC >63 μM | In vitro | None | NA | NA | None | None | NA | Ecumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicin | ClpC1 ATPase complex | None | NA | 2015 | 25421483 |
antitb_1869 | Mastoparan Polybia-MPII | INWLKLGKMVIDAL | Free | Free | None | Linear | 14 | L | Cationic | Natural | Isolated from venom of the social wasp Pseudopolybia vespiceps testacea | Mycobacterium abscessus | Mycobacterium abscessus subsp. massiliense GO06 | 80% inhibition at 12.5 μM | In vitro | murine macrophages, human and mouse erythrocytes | 80% inhibition at 12.5 μM | 50% hemolysis at 24.18 μM and 48.47 μM against mouse and human erythrocytes respectively | NA | NA | NA | membrane pore formation | cell membrane | NA | Antifungal (Candida albicans and Cryptococcus neoformans) and Antibacterial (Staphylococcus aureus) | 2017 | 28108242 |
antitb_1881 | Polydim-I | AVAGEKLWLLPHLLKMLLTPTP | Free | Free | None | Linear | 22 | L | Amphipathic | Natural | Isolated from the venom of the Neotropical wasp Polybia dimorpha | Mycobacterium abscessus | Mycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus) | MIC = 60.8 μg/mL | Both | Peritoneal macrophages, J774 macrophages cells, human red blood cells | Treatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load | Non-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity | 6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice | 2 mg/kg/mLW shows 90% reduction in bacterial load | NA | Cell wall disruption | Cell wall | None | NA | 2016 | 26930596 |
antitb_1950 | NDBP-5 | IFSAIAGLLSNLL | Free | Free | None | Linear | 13 | L | Cationic | Natural | Derived from scorpion hadrurus gertschi | Mycobacterium abscessus | Mycobacterium abscessus subsp. Massiliene GO01 | MIC = 100 μM | In vitro | Human erythrocyte | NA | No cytotoxicity | BALB/c mice | 2mg/kg | IFN-y production | NA | NA | NA | NA | 2017 | 28275372 |
antitb_1951 | NDBP-5 | IFSAIAGLLSNLL | Free | Free | None | Linear | 13 | L | Cationic | Natural | Derived from scorpion hadrurus gertschi | Mycobacterium abscessus | Mycobacterium abscessus subsp. Massiliene GO06 | MIC = 100 μM | In vitro | Human erythrocyte | NA | No cytotoxicity | BALB/c mice | 2mg/kg | IFN-y production | NA | NA | NA | NA | 2017 | 28275372 |
antitb_1952 | NDBP-5 | IFSAIAGLLSNLL | Free | Free | None | Linear | 13 | L | Cationic | Natural | Derived from scorpion hadrurus gertschi | Mycobacterium abscessus | Mycobacterium abscessus subsp. Massiliene GO08 | MIC = 100 μM | In vitro | Human erythrocyte | NA | No cytotoxicity | BALB/c mice | 2mg/kg | IFN-y production | NA | NA | NA | NA | 2017 | 28275372 |