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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 7
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1001Polydim-I AVAGEKLWLLPHLLKMLLTPTPFreeFreeNoneLinear22LAmphipathicNaturalIsolated from the venom of the Neotropical wasp Polybia dimorpha Mycobacterium abscessus subsp. massiliense Mycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus)MIC = 60.8 μg/mL BothPeritoneal macrophages, J774 macrophages cells, human red blood cells Treatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load Non-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice 2 mg/kg/mLW shows 90% reduction in bacterial loadNACell wall disruption Cell wallNoneNA201626930596
antitb_1016Ecumicin (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val)FreeFreeN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = PheMacrocyclic13LNANaturalProduced by a genetically distinct Nonomuraea species, strain MJM5123. Mycobacterium abscessusMycobacterium abscessus (ATCC 19977) MIC >63 μMIn vitroNoneNANANone NoneNAEcumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. so toxic proteins which are normally degraded by the ClpC1P1P2 complex, accumulate in the presence of ecumicinClpC1 ATPase complex NoneNA201525421483
antitb_1869Mastoparan Polybia-MPIIINWLKLGKMVIDALFreeFreeNoneLinear14LCationicNaturalIsolated from venom of the social wasp Pseudopolybia vespiceps testaceaMycobacterium abscessusMycobacterium abscessus subsp. massiliense GO0680% inhibition at 12.5 μMIn vitromurine macrophages, human and mouse erythrocytes80% inhibition at 12.5 μM50% hemolysis at 24.18 μM and 48.47 μM against mouse and human erythrocytes respectivelyNA NANAmembrane pore formationcell membraneNAAntifungal (Candida albicans and Cryptococcus neoformans) and Antibacterial (Staphylococcus aureus)201728108242
antitb_1881Polydim-I AVAGEKLWLLPHLLKMLLTPTPFreeFreeNoneLinear22LAmphipathicNaturalIsolated from the venom of the Neotropical wasp Polybia dimorpha Mycobacterium abscessusMycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus)MIC = 60.8 μg/mL BothPeritoneal macrophages, J774 macrophages cells, human red blood cells Treatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load Non-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice 2 mg/kg/mLW shows 90% reduction in bacterial loadNACell wall disruption Cell wallNoneNA201626930596
antitb_1950NDBP-5IFSAIAGLLSNLLFreeFreeNoneLinear13LCationicNaturalDerived from scorpion hadrurus gertschiMycobacterium abscessus Mycobacterium abscessus subsp. Massiliene GO01MIC = 100 μMIn vitroHuman erythrocyteNANo cytotoxicityBALB/c mice 2mg/kgIFN-y productionNANANANA201728275372
antitb_1951NDBP-5IFSAIAGLLSNLLFreeFreeNoneLinear13LCationicNaturalDerived from scorpion hadrurus gertschiMycobacterium abscessusMycobacterium abscessus subsp. Massiliene GO06MIC = 100 μMIn vitroHuman erythrocyteNANo cytotoxicityBALB/c mice 2mg/kgIFN-y productionNANANANA201728275372
antitb_1952NDBP-5IFSAIAGLLSNLLFreeFreeNoneLinear13LCationicNaturalDerived from scorpion hadrurus gertschiMycobacterium abscessusMycobacterium abscessus subsp. Massiliene GO08MIC = 100 μMIn vitroHuman erythrocyteNANo cytotoxicityBALB/c mice 2mg/kgIFN-y productionNANANANA201728275372