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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 44
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1334Cairomycin Bnot availableNANANACyclic0MixNANaturalStreptomyces fungusMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC= 50 μg/mL BothNANANASwiss mice 3 mg/kg of body weightNANANANAAntimicrobial against S.aureus, B.subtilis, P.aureginosa,Pseudomonas. Antifungal also.1976855995
antitb_1335Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium tuberculosis Mycobacterium tuberculosis H37RvIC50 = <0.0125 μg/mL (50%)BothNANANAICR/JCL male mice and male beagle dogs 10 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1336Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium intracellulareMycobacterium intracellulareIC50 = 1.56 μg/mL (50%)BothNANANAICR/JCL male mice and male beagle dogs 11 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1337Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium kansasiiMycobacterium kansasiiIC50= 0.39 μg/mL (50%)BothNANANAICR/JCL male mice and male beagle dogs 12 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1338Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium tuberculosis Mycobacterium tuberculosis H37RvIC90= 0.05 μg/mL(90%)BothNANANAICR/JCL male mice and male beagle dogs 13 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1339Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium intracellulareMycobacterium intracellulareIC90= 0.78 μg/mL(90%)BothNANANAICR/JCL male mice and male beagle dogs 14 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1340Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium kansasiiMycobacterium kansasiiIC90= 0.78 μg/mL(90%)BothNANANAICR/JCL male mice and male beagle dogs 15 mg/kg for mice and 50mg/kg for dogNANANANANA19883348603
antitb_1341Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium bovisMycobacterium tuberculosis H37RvNABothNANANAICR/JCL Mice 15 mg/kg for mice and 50mg/kg for dogNANANA4mg of DHMPA peptide+ 0.1 mg of IsoniazidNA19883348603
antitb_1342Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium tuberculosis Mycobacterium tuberculosis R-KMNABothNANANAICR/JCL Mice 15 mg/kg for mice and 50mg/kg for dogNANANA4mg of DHMPA peptide+ 0.1 mg of IsoniazidNA19883348603
antitb_1343Dihydromycoplanecin AR-N(CH3)-CH(CH-CH3-CH3)-CO-N(CH-C-CH2-CH3-C-CH)-CO-N(CH3)-CH-C)-NH-CH(CH2-CH-CH3-CH3)-CO-N-CH-C-CH3_C-CH)-CONH-CH(CH2-CH2-CH-CH3-CH3)-Co-N-CH3-Ch-CH(CH3-CH3)-Co-N-(CH-C-Ch)-Co-N(CH3)-CH(CH2-CH-CH3-CH3)-CO-NH-CH2-CO-O-CH(CH3)Propanol is attached FreeR =CH3-CH2-CH(OH)-COCyclic21MixNANaturalAspergillus awajinensisMycobacterium smegmatisMycobacterium smegmatis ATCC 607FIC= 0.250 - 0.375 NANANANANA NANANANADHMPA+ IsoniazidNA19883348603
antitb_1762FKAB-1G2G-dF-Tic-Oic-GK-Tic-Oic-G-dF-Tic-Oic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19MixHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1763FKAB-1G3GF-Tic-Oic-G-dK-Tic-Oic-GF-Tic-Oic-G-dK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19MixHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1803Peptide-47G-f-Tic-Oic-GK-Tic-Oic-G-f-Tic-Oic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19MixAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 10 µM or 24 µg/mLBothNANANot testedNA NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1804Peptide-48GF-Tic-Oic-G-k-Tic-Oic-GF-Tic-Oic-G-k-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19MixAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 10 µM or 24 µg/mLBothNANANot testedNA NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1832Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 11.3 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1833Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X004439MIC = 9.3 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1834Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X004244MIC = 16.9 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1835Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X005282MIC = 9.6 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1836Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X005319MIC = 19.2 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1837Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X001354MIC = 9.7 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1838Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X003899MIC = 22.9 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1839Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to streptomycin (rSM, ATCC 35820)MIC = 11.6 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1840Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to rifampin (rRMP, ATCC 35838)MIC = 9.6 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1841Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to kanamycin (rKM, ATCC 35827)MIC = 12.4 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1842Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to isoniazid (rINH, ATCC 35822)MIC = 12.1 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1843Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to cycloserine (rCS, ATCC 35826)MIC = 20.6 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1844Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to moxifloxacin (rMOX)MIC = 9.0 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1845Hytramycin V(METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moietiesCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to capreomycin (rCAP)MIC = 12.1 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1846Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMIC = 6.0 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1847Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X004439MIC = 4.4 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1848Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X004244MIC = 4.7 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1849Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X005282MIC = 4.7 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1850Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X005319MIC = 4.8 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1851Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X001354MIC = 4.7 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1852Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisClinical isolate, X003899MIC = 4.8 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1853Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to streptomycin (rSM, ATCC 35820)MIC = 4.7 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1854Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to rifampin (rRMP, ATCC 35838)MIC = 4.7 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1855Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to kanamycin (rKM, ATCC 35827)MIC = 4.9 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1856Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to isoniazid (rINH, ATCC 35822)MIC = 4.7 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1857Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to cycloserine (rCS, ATCC 35826)MIC = 7.4 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1858Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to moxifloxacin (rMOX)MIC = 4.0 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1859Hytramycin I(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)FreeFreeMETH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucineCyclic (Intrachain bond between 1-6)6MixNANaturalFrom Streptomyces hygroscopicus strain ECUM 14046Mycobacterium tuberculosisMycobacterium tuberculosis resistant to capreomycin (rCAP)MIC = 4.8 μg/mLIn vitroNoneNANANA NANANANANAAntibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)201324224794
antitb_1972GranulysinRLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLRLCIPSTGPLFreeFreeNoneLinear123MixCationicNaturalHomo sapiensMycobacterium tuberculosisMycobacterium tuberculosis90% KillingIn vivoCD8+ TNANANA NANAAltering Membrane Permeabilitycell wall (lipid bilayer)Perforin (2000 U/ml)+granulysin (25 µM)Cryptococcus neoformans, Candida albicans, Leishmania major, S. typhimurium, L. monocytogenes, E. coli, and Staphylococcus aureus19889756476
antitb_1973GranulysinRLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLRLCIPSTGPLFreeFreeNoneLinear123MixCationicNaturalHomo sapiensMycobacterium tuberculosisMycobacterium tuberculosis10-15% KillingIn vivoCD8+ TNANANA NANAAltering Membrane Permeabilitycell wall (lipid bilayer)NACryptococcus neoformans, Candida albicans, Leishmania major, S. typhimurium, L. monocytogenes, E. coli, and Staphylococcus aureus19889756476