4TSS	Toxin	date	Dec 11, 1996
title	Toxic Shock Syndrome Toxin-1: Tetragonal P4(1)2(1)2 Crystal Form
authors	G.S.Prasad, R.Radhakrishnan, D.T.Mitchell, C.A.Earhart, M.M.Dinges, W.J.Cook, P.M.Schlivert, D.H.Ohlendorf
compound		source
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A Synonym: Tsst-1		Organism_scientific: Staphylococcus Aureus Strain: Mn 8 Cellular_location: Secreted Other_details: Purchased From Toxin Technologies
symmetry	Space Group: P 41 21 2	R_factor	0.191
crystal cell	length a length b length c angle alpha angle beta angle gamma 47.300 47.300 205.800 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.75 Å
ligand	ZN	enzyme
related structures	by homologous chain: 1QIL, 5TSS
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc.	Secreted protein.
Gene	TST (S. aureus)
function	Responsible for the symptoms of toxic shock syndrome.
Gene Ontology	Chain Function Process Component A pathogenesis extracellular region
Primary reference	Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci 1997 Jun;6(6):1220-7. PMID:9194182

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (35 Kb) [Save to disk] Biological Unit Coordinates (4tss.pdb1.gz) 32 Kb CSU: Contacts of Structural Units for 4TSS Likely Quarternary Molecular Structure file(s) for 4TSS Retrieve 4TSS in mmCIF format [Save to disk]

View 4TSS in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 4TSS

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 4TSS, from MSDmotif at EBI Genome occurence of 4TSS's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d4tss_1, region 1-93 [Jmol] [rasmolscript] [script source]     - Domain d4tss_2, region 94-194 [Jmol] [rasmolscript] [script source] Fold representative 4tss from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [4tss_A]

Other resources with information on 4TSS

InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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