3TSS	Toxin	date	Dec 11, 1996
title	Toxic Shock Syndrome Toxin-1 Tetramutant, P2(1) Crystal Form
authors	G.S.Prasad, R.Radhakrishnan, D.T.Mitchell, C.A.Earhart, M.M.Dinges, W.J.Cook, P.M.Schlivert, D.H.Ohlendorf
compound		source
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A Engineered: Yes Mutation: Yes		Organism_scientific: Staphylococcus Aureus Strain: Rn8361 Cellular_location: Secreted
symmetry	Space Group: P 1 21 1	R_factor	0.173
crystal cell	length a length b length c angle alpha angle beta angle gamma 44.360 33.960 55.180 90.00 92.96 90.00
method	X-Ray Diffraction	resolution	1.90 Å
note	3TSS is a representative structure
related structures	by homologous chain: 1AW7
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc.	Secreted protein.
Gene	TST (S. aureus)
function	Responsible for the symptoms of toxic shock syndrome.
Gene Ontology	Chain Function Process Component A pathogenesis extracellular region
Primary reference	Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci 1997 Jun;6(6):1220-7. PMID:9194182

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (36 Kb) [Save to disk] Biological Unit Coordinates (3tss.pdb1.gz) 33 Kb CSU: Contacts of Structural Units for 3TSS Likely Quarternary Molecular Structure file(s) for 3TSS Retrieve 3TSS in mmCIF format [Save to disk]

View 3TSS in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 3TSS

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 3TSS, from MSDmotif at EBI Genome occurence of 3TSS's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d3tss_1, region 5-93 [Jmol] [rasmolscript] [script source]     - Domain d3tss_2, region 94-194 [Jmol] [rasmolscript] [script source] Fold representative 3tss from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [3tss_A]

Other resources with information on 3TSS

InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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