3SEB	Toxin	date	Nov 26, 1997
title	Staphylococcal Enterotoxin B
authors	A.C.Papageorgiou, K.R.Acharya
compound		source
Molecule: Staphylococcal Enterotoxin B Chain: A Synonym: Seb		Organism_scientific: Staphylococcus Aureus
symmetry	Space Group: P 21 21 21	R_factor
crystal cell	length a length b length c angle alpha angle beta angle gamma 45.404 67.720 79.065 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	1.48 Å
note	3SEB is a representative structure
related structures	by homologous chain: 1BXT
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subcellular loc.	Secreted protein.
Gene	ENTB (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A pathogenesis extracellular region
Primary reference	Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors., Papageorgiou AC, Tranter HS, Acharya KR, J Mol Biol 1998 Mar 20;277(1):61-79. PMID:9514739

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (47 Kb) [Save to disk] Biological Unit Coordinates (3seb.pdb1.gz) 43 Kb CSU: Contacts of Structural Units for 3SEB Likely Quarternary Molecular Structure file(s) for 3SEB Retrieve 3SEB in mmCIF format [Save to disk]

View 3SEB in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 3SEB

Protein Explorer, Easier to use and more powerful than RasMol. (Win and Mac only) Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges. Cartoon representation from PDB Cartoon Ramachandran plot from PDBSum

Structure-derived information

Conformational Epitope Prediction for 3SEB from the CEP Server. Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 3SEB, from MSDmotif at EBI Genome occurence of 3SEB's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d3seb_1, region 1-121 [Jmol] [rasmolscript] [script source]     - Domain d3seb_2, region 122-238 [Jmol] [rasmolscript] [script source] Fold representative 3seb from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [3seb_A]

Other resources with information on 3SEB

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

Movements, Movies and Images

Domain movements in 3SEB from the Database of Macromolecular Movements. Images from IMB Jena Image Library of Biological Macromolecules.

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