2TSS	Toxin	date	Dec 04, 1996
title	Toxic Shock Syndrome Toxin-1 From Staphylococcus Aureus: Orthorhombicc222(1) Crystal Form
authors	G.S.Prasad, R.Radhakrishnan, D.T.Mitchell, C.A.Earhart, M.M.Dinges, W.J.Cook, P.M.Schlivert, D.H.Ohlendorf
compound		source
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A, B, C Synonym: Tsst-1		Organism_scientific: Staphylococcus Aureus
symmetry	Space Group: C 2 2 21	R_factor	0.154
crystal cell	length a length b length c angle alpha angle beta angle gamma 108.700 177.500 97.600 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.05 Å
note	2TSS supersedes 1TSS
related structures	by homologous chain: 1TS3, 2QIL
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc.	Secreted protein.
Gene	TST (S. aureus)
function	Responsible for the symptoms of toxic shock syndrome.
Gene Ontology	Chain Function Process Component A, C, B pathogenesis extracellular region
Primary reference	Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci 1997 Jun;6(6):1220-7. PMID:9194182

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (107 Kb) [Save to disk] Biological Unit Coordinates (2tss.pdb1.gz) 42 Kb Biological Unit Coordinates (2tss.pdb2.gz) 34 Kb Biological Unit Coordinates (2tss.pdb3.gz) 34 Kb CSU: Contacts of Structural Units for 2TSS Likely Quarternary Molecular Structure file(s) for 2TSS Retrieve 2TSS in mmCIF format [Save to disk]

View 2TSS in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 2TSS

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 2TSS, from MSDmotif at EBI Genome occurence of 2TSS's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d2tssa1, region A:1-93 [Jmol] [rasmolscript] [script source]     - Domain d2tssa2, region A:94-194 [Jmol] [rasmolscript] [script source]     - Domain d2tssb1, region B:1-93 [Jmol] [rasmolscript] [script source]     - Domain d2tssb2, region B:94-194 [Jmol] [rasmolscript] [script source]     - Domain d2tssc1, region C:1-93 [Jmol] [rasmolscript] [script source]     - Domain d2tssc2, region C:94-194 [Jmol] [rasmolscript] [script source] Fold representative 2tss from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [2tss_A] [2tss_C] [2tss_B]

Other resources with information on 2TSS

InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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