2SAK	Plasminogen Activator	date	Feb 20, 1997
title	Staphylokinase (Sakstar Variant)
authors	A.Rabijns, H.L.De Bondt, M.De Maeyer, I.Lasters, C.De Ranter
compound		source
Molecule: Staphylokinase Chain: A Mutation: Yes		Organism_scientific: Staphylococcus Aureus
symmetry	Space Group: C 1 2 1	R_factor	0.181
crystal cell	length a length b length c angle alpha angle beta angle gamma 60.600 43.730 54.270 90.00 115.63 90.00
method	X-Ray Diffraction	resolution	1.80 Å
ligand	TRS	enzyme
note	2SAK is a representative structure
related structures	by homologous chain: 1C76
similarity	Belongs to the Staphylokinase family.
subcellular loc.	Secreted protein.
Gene	SAK (S. aureus)
function	Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1. 1 complex with plasmin, which in turn activates other plasminogen molecules.
Gene Ontology	Chain Function Process Component A plasminogen activator activi...
Primary reference	Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential., Rabijns A, De Bondt HL, De Ranter C, Nat Struct Biol 1997 May;4(5):357-60. PMID:9145104

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (25 Kb) [Save to disk] Biological Unit Coordinates (2sak.pdb1.gz) 42 Kb CSU: Contacts of Structural Units for 2SAK Likely Quarternary Molecular Structure file(s) for 2SAK Retrieve 2SAK in mmCIF format [Save to disk]

View 2SAK in 3D

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Visual 3D analysis of 2SAK

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 2SAK, from MSDmotif at EBI Genome occurence of 2SAK's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d2sak__, region [Jmol] [rasmolscript] [script source] Fold representative 2sak from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [2sak_A]

Other resources with information on 2SAK

InterPro: IPR004093 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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