2HSQ	Cell Adhesion, Structural Protein	date	Jul 22, 2006
title	Human Vinculin (Head Domain, Vh1, Residues 1-258) In Complex With Shigella'S Ipaa Vinculin Binding Site 2 (Residues 565-587)
authors	T.Izard
compound		source
Molecule: Vinculin Chain: A Synonym: Metavinculin Engineered: Yes		Organism_scientific: Homo Sapiens Organism_common: Human Gene: Vcl Expression_system: Escherichia Coli Expression_system_common: Bacteria
Molecule: Invasin Ipaa Chain: B Synonym: 70 Kda Antigen Engineered: Yes		Organism_scientific: Shigella Flexneri Organism_common: Bacteria Gene: Ipaa Expression_system: Escherichia Coli Expression_system_common: Bacteria
symmetry	Space Group: I 4 3 2	R_factor	0.286
crystal cell	length a length b length c angle alpha angle beta angle gamma 203.170 203.170 203.170 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	3.97 Å
Genes	CP0125, IPAA (S. flexneri); VCL (H. sapiens)
Gene Ontology	Chain Function Process Component A actin binding structural molecule activity... protein binding oxidoreductase activity alpha-catenin binding cell motility cell adhesion lamellipodium biogenesis regulation of cell migration... negative regulation of cell ... apical junction assembly cytoplasm cytoskeleton plasma membrane intercellular junction adherens junction fascia adherens focal adhesion actin cytoskeleton cell junction cell-matrix junction costamere protein complex
Primary reference	Shigella applies molecular mimicry to subvert vinculin and invade host cells., Izard T, Tran Van Nhieu G, Bois PR, J Cell Biol. 2006 Nov 6;175(3):465-75. PMID:17088427

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (46 Kb) [Save to disk] Biological Unit Coordinates (2hsq.pdb1.gz) 42 Kb CSU: Contacts of Structural Units for 2HSQ Likely Quarternary Molecular Structure file(s) for 2HSQ Retrieve 2HSQ in mmCIF format [Save to disk]

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 2HSQ, from MSDmotif at EBI Fold representative 2hsq from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [2hsq_A] [2hsq_B]

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