2FJC	Metal Transport	date	Jan 02, 2006
title	Crystal Structure Of Antigen Tpf1 From Treponema Pallidum
authors	A.Thumiger, A.Polenghi, E.Papinutto, R.Battistutta, C.Montecucco, G.Zanotti
compound		source
Molecule: Antigen Tpf1 Chain: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P Synonym: Antigen C1-5, Antigen 4d Engineered: Yes		Organism_scientific: Treponema Pallidum Organism_common: Bacteria Gene: Tpf1 Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Xl 1blue Expression_system_vector_type: Plasmid Expression_system_plasmid: Psm214g-Tpf1
symmetry	Space Group: P 3 2 1	R_factor	0.227
crystal cell	length a length b length c angle alpha angle beta angle gamma 184.921 184.921 154.883 90.00 90.00 120.00
method	X-Ray Diffraction	resolution	2.50 Å
ligand	FE	enzyme
note	2FJC is a representative structure
similarity	Belongs to the dps family.[Ferritin]
subunit	Homodecamer; either linked or stabilized by disulfide bonds.
Gene	TPF1 (T. pallidum); TP (T. pallidum)
function	May play an important structural role in the outer membrane.
Gene Ontology	Chain Function Process Component F, N, K, E, M, C, L, A, J, O, P, B, H, D, I, G ferric iron binding oxidoreductase activity transition metal ion binding... cellular iron ion homeostasi... response to stress
Primary reference	Crystal structure of antigen TpF1 from Treponema pallidum., Thumiger A, Polenghi A, Papinutto E, Battistutta R, Montecucco C, Zanotti G, Proteins. 2005 Dec 12;. PMID:16345079

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (393 Kb) [Save to disk] Biological Unit Coordinates (2fjc.pdb1.gz) 294 Kb Biological Unit Coordinates (2fjc.pdb2.gz) 285 Kb CSU: Contacts of Structural Units for 2FJC Likely Quarternary Molecular Structure file(s) for 2FJC Structure Factors (918 Kb) Retrieve 2FJC in mmCIF format [Save to disk]

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Visual 3D analysis of 2FJC

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 2FJC, from MSDmotif at EBI Fold representative 2fjc from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [2fjc_C] [2fjc_K] [2fjc_B] [2fjc_E] [2fjc_L] [2fjc_F] [2fjc_G] [2fjc_D] [2fjc_A] [2fjc_N] [2fjc_H] [2fjc_P] [2fjc_J] [2fjc_I] [2fjc_O] [2fjc_M]

Other resources with information on 2FJC

InterPro: IPR012347 , IPR002177 , IPR008331 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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