2C4L	Hydrolase	date	Oct 20, 2005
title	Structure Of Neuraminidase Subtype N9 Complexed With 30 Mm Sialic Acid (Nana, Neu5ac), Crystal Soaked For 24 Hours At 291 K And Finally Backsoaked For 30 Min In A Cryoprotectant Solution Which Did Not Contain Neu5ac
authors	E.Rudino-Pinera, P.Tunnah, S.J.Crennell, R.G.Webster, W.G.Laver, E.F.Garman
compound		source
Molecule: Neuraminidase Subtype N9 Chain: A Fragment: Residues 83-470 Ec: 3.2.1.18 Engineered: Yes		Organism_scientific: Influenza A Virus Organism_common: Avian Influenza Virus A Organism_taxid: 11320 Strain: Aternsterna Albifronsn9 Expression_system: Gallus Gallus Expression_system_taxid: 9031
symmetry	Space Group: I 4 3 2	R_factor 0.155 R_Free 0.196
crystal cell	length a length b length c angle alpha angle beta angle gamma 181.178 181.178 181.178 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2 Å
ligand	BMA, CA, MAN, NAG, SIA	enzyme	Hydrolase E.C.3.2.1.18 BRENDA
Gene	NA
Gene Ontology	Chain Function Process Component A exo-alpha-sialidase activity... calcium ion binding hydrolase activity hydrolase activity, acting o... metal ion binding carbohydrate metabolic proce... metabolic process plasma membrane membrane integral to membrane virion host cell plasma membrane virion membrane

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (80 Kb) [Save to disk] Biological Unit Coordinates (2c4l.pdb1.gz) 277 Kb CSU: Contacts of Structural Units for 2C4L Likely Quarternary Molecular Structure file(s) for 2C4L Structure Factors (243 Kb) Retrieve 2C4L in mmCIF format [Save to disk]

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 2C4L, from MSDmotif at EBI Fold representative 2c4l from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [2c4l_A]

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