1UNS	Toxin	date	Sep 15, 2003
title	Identification Of A Secondary Zinc-Binding Site In Staphylococcal Enterotoxin C2: Implications For Superantigen Recognition
authors	A.C.Papageorgiou, M.D.Baker, J.D.Mcleod, S.Goda, D.M.Sansom, H.S.Tranter, K.R.Acharya
compound		source
Molecule: Enterotoxin Type C-2 Chain: A Synonym: Staphylococcal Enterotoxin C2, Sec2		Organism_scientific: Staphylococcus Aureus
symmetry	Space Group: P 21 21 21	R_factor	0.198
crystal cell	length a length b length c angle alpha angle beta angle gamma 42.500 44.540 131.650 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.00 Å
ligand	ZN	enzyme
related structures	by homologous chain: 1KLU, 1STE
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subcellular loc.	Secreted protein.
Gene	ENTC2 (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A zinc ion binding metal ion binding pathogenesis extracellular region
Primary reference	Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition., Papageorgiou AC, Baker MD, McLeod JD, Goda SK, Manzotti CN, Sansom DM, Tranter HS, Acharya KR, J Biol Chem 2004 Jan 9;279(2):1297-303. Epub 2003 Oct 14. PMID:14559915

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (44 Kb) [Save to disk] Biological Unit Coordinates (1uns.pdb1.gz) 41 Kb CSU: Contacts of Structural Units for 1UNS Likely Quarternary Molecular Structure file(s) for 1UNS Retrieve 1UNS in mmCIF format [Save to disk]

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1UNS, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1unsa1, region A:1-120 [Jmol] [rasmolscript] [script source]     - Domain d1unsa2, region A:121-236 [Jmol] [rasmolscript] [script source] Fold representative 1uns from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1uns_A]

Other resources with information on 1UNS

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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