1TS4	Toxin	date	Oct 10, 1997
title	Q139k Mutant Of Toxic Shock Syndrome Toxin-1 From S. Aureus
authors	C.A.Earhart, D.T.Mitchell, D.L.Murray, D.M.Pinheiro, M.Matsumura, P.M.Schlievert, D.H.Ohlendorf
compound		source
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A, B Synonym: Tsst-1 Engineered: Yes Mutation: Yes		Organism_scientific: Staphylococcus Aureus Expression_system: Staphylococcus Aureus
symmetry	Space Group: H 3 2	R_factor	0.210
crystal cell	length a length b length c angle alpha angle beta angle gamma 152.350 152.350 142.310 90.00 90.00 120.00
method	X-Ray Diffraction	resolution	3.40 Å
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc.	Secreted protein.
Gene	TST (S. aureus)
function	Responsible for the symptoms of toxic shock syndrome.
Gene Ontology	Chain Function Process Component A, B pathogenesis extracellular region
Primary reference	Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry 1998 May 19;37(20):7194-202. PMID:9585531

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (65 Kb) [Save to disk] Biological Unit Coordinates (1ts4.pdb1.gz) 32 Kb Biological Unit Coordinates (1ts4.pdb2.gz) 32 Kb CSU: Contacts of Structural Units for 1TS4 Likely Quarternary Molecular Structure file(s) for 1TS4 Retrieve 1TS4 in mmCIF format [Save to disk]

View 1TS4 in 3D

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Visual 3D analysis of 1TS4

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1TS4, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1ts4a1, region A:1-93 [Jmol] [rasmolscript] [script source]     - Domain d1ts4a2, region A:94-194 [Jmol] [rasmolscript] [script source]     - Domain d1ts4b1, region B:201-293 [Jmol] [rasmolscript] [script source]     - Domain d1ts4b2, region B:294-394 [Jmol] [rasmolscript] [script source] Fold representative 1ts4 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1ts4_B] [1ts4_A]

Other resources with information on 1TS4

InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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