1TS2 | Toxin | date | Oct 09, 1997 ![]() ![]() |
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title | T128a Mutant Of Toxic Shock Syndrome Toxin-1 From S. Aureus | ||||||||||||||
authors | C.A.Earhart, D.T.Mitchell, D.L.Murray, D.M.Pinheiro, M.Matsumura, P.M.Schlievert, D.H.Ohlendorf | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A, B, C Synonym: Tsst-1 Engineered: Yes Mutation: Yes |
Organism_scientific: Staphylococcus Aureus Expression_system: Staphylococcus Aureus | ||||||||||||||
symmetry | Space Group: C 2 2 21 | R_factor | |||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 2.30 Å | ||||||||||||
related structures | by homologous chain: 1QIL, 2QIL | ||||||||||||||
similarity | Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin] | ||||||||||||||
subcellular loc. | Secreted protein. | ||||||||||||||
Gene | TST (S. aureus) | ||||||||||||||
function | Responsible for the symptoms of toxic shock syndrome. | ||||||||||||||
Gene Ontology |
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Primary reference | Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry 1998 May 19;37(20):7194-202. PMID:9585531 |
Data retrieval |
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View 1TS2 in 3D |
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Visual 3D analysis of 1TS2 |
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Structure-derived information |
- Domain d1ts2a1, region A:1-93 [Jmol] [rasmolscript] [script source] - Domain d1ts2a2, region A:94-194 [Jmol] [rasmolscript] [script source] - Domain d1ts2b1, region B:201-293 [Jmol] [rasmolscript] [script source] - Domain d1ts2b2, region B:294-394 [Jmol] [rasmolscript] [script source] - Domain d1ts2c1, region C:401-493 [Jmol] [rasmolscript] [script source] - Domain d1ts2c2, region C:494-594 [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
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