1TS2	Toxin	date	Oct 09, 1997
title	T128a Mutant Of Toxic Shock Syndrome Toxin-1 From S. Aureus
authors	C.A.Earhart, D.T.Mitchell, D.L.Murray, D.M.Pinheiro, M.Matsumura, P.M.Schlievert, D.H.Ohlendorf
compound		source
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A, B, C Synonym: Tsst-1 Engineered: Yes Mutation: Yes		Organism_scientific: Staphylococcus Aureus Expression_system: Staphylococcus Aureus
symmetry	Space Group: C 2 2 21	R_factor
crystal cell	length a length b length c angle alpha angle beta angle gamma 108.840 177.400 97.220 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.30 Å
related structures	by homologous chain: 1QIL, 2QIL
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc.	Secreted protein.
Gene	TST (S. aureus)
function	Responsible for the symptoms of toxic shock syndrome.
Gene Ontology	Chain Function Process Component A, C, B pathogenesis extracellular region
Primary reference	Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry 1998 May 19;37(20):7194-202. PMID:9585531

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (102 Kb) [Save to disk] Biological Unit Coordinates (1ts2.pdb1.gz) 37 Kb Biological Unit Coordinates (1ts2.pdb2.gz) 33 Kb Biological Unit Coordinates (1ts2.pdb3.gz) 32 Kb CSU: Contacts of Structural Units for 1TS2 Likely Quarternary Molecular Structure file(s) for 1TS2 Retrieve 1TS2 in mmCIF format [Save to disk]

View 1TS2 in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1TS2

Protein Explorer, Easier to use and more powerful than RasMol. (Win and Mac only) Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges. Cartoon representation from PDB Cartoon Ramachandran plot from PDBSum

Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1TS2, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1ts2a1, region A:1-93 [Jmol] [rasmolscript] [script source]     - Domain d1ts2a2, region A:94-194 [Jmol] [rasmolscript] [script source]     - Domain d1ts2b1, region B:201-293 [Jmol] [rasmolscript] [script source]     - Domain d1ts2b2, region B:294-394 [Jmol] [rasmolscript] [script source]     - Domain d1ts2c1, region C:401-493 [Jmol] [rasmolscript] [script source]     - Domain d1ts2c2, region C:494-594 [Jmol] [rasmolscript] [script source] Fold representative 1ts2 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1ts2_B] [1ts2_A] [1ts2_C]

Other resources with information on 1TS2

InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

Movements, Movies and Images

Images from IMB Jena Image Library of Biological Macromolecules.

You may enter another PDB ID code

Go [Back], to the [PDB Lite page], to the [OCA Search page] or to the [PDB Home page]

---

OCA© by Jaime Prilusky, 1996-2007
Bioinformatics and Biological Computing
Weizmann Institute of Science

---