1SXT	Superantigen	date	Nov 14, 1996
title	Staphylococcal Enterotoxin Type A (Sea) Co-Crystallised With Zinc
authors	S.M.Sundstrom
compound		source
Molecule: Staphylococcal Enterotoxin Type A Chain: A, B Synonym: Sea Engineered: Yes		Organism_scientific: Staphylococcus Aureus Expression_system: Escherichia Coli
symmetry	Space Group: P 31 2 1	R_factor	0.206
crystal cell	length a length b length c angle alpha angle beta angle gamma 75.590 75.590 175.310 90.00 90.00 120.00
method	X-Ray Diffraction	resolution	2.70 Å
ligand	ZN	enzyme
related structures	by homologous chain: 1I4G, 1I4H
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subunit	Monomer.
subcellular loc.	Secreted protein.
Gene	ENTA (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A, B zinc ion binding metal ion binding pathogenesis extracellular region
Primary reference	The Co-crystal structure of staphylococcal enterotoxin type A with Zn2+ at 2.7 A resolution. Implications for major histocompatibility complex class II binding., Sundstrom M, Hallen D, Svensson A, Schad E, Dohlsten M, Abrahmsen L, J Biol Chem 1996 Dec 13;271(50):32212-6. PMID:8943278

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (76 Kb) [Save to disk] Biological Unit Coordinates (1sxt.pdb1.gz) 37 Kb Biological Unit Coordinates (1sxt.pdb2.gz) 37 Kb CSU: Contacts of Structural Units for 1SXT Likely Quarternary Molecular Structure file(s) for 1SXT Retrieve 1SXT in mmCIF format [Save to disk]

View 1SXT in 3D

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Visual 3D analysis of 1SXT

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1SXT, from MSDmotif at EBI Genome occurence of 1SXT's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1sxta1, region A:10-120 [Jmol] [rasmolscript] [script source]     - Domain d1sxta2, region A:121-233 [Jmol] [rasmolscript] [script source]     - Domain d1sxtb1, region B:10-120 [Jmol] [rasmolscript] [script source]     - Domain d1sxtb2, region B:121-233 [Jmol] [rasmolscript] [script source] Fold representative 1sxt from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1sxt_A] [1sxt_B]

Other resources with information on 1SXT

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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