1SE3	Toxin	date	Oct 11, 1996
title	Staphylococcal Enterotoxin B Complexed With Gm3 Trisaccharide
authors	S.Swaminathan, M.Sax
compound		source
Molecule: Staphylococcal Enterotoxin B Chain: A Synonym: Seb Engineered: Yes Other_details: Complexed With Gm3 Trisaccharide (3'- Sialyllactose)		Organism_scientific: Staphylococcus Aureus Cell_line: S2 Expression_system: Staphylococcus Aureus
symmetry	Space Group: P 21 21 21	R_factor	0.220
crystal cell	length a length b length c angle alpha angle beta angle gamma 45.300 71.000 78.400 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.30 Å
ligand	GAL, GLC, SIA	enzyme
related structures	by homologous chain: 1JWU, 1KLG
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subcellular loc.	Secreted protein.
Gene	ENTB (S. aureus)
function	The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene Ontology	Chain Function Process Component A pathogenesis extracellular region
Primary reference	Residues defining V beta specificity in staphylococcal enterotoxins., Swaminathan S, Furey W, Pletcher J, Sax M, Nat Struct Biol 1995 Aug;2(8):680-6. PMID:7552730

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (48 Kb) [Save to disk] Biological Unit Coordinates (1se3.pdb1.gz) 44 Kb CSU: Contacts of Structural Units for 1SE3 Likely Quarternary Molecular Structure file(s) for 1SE3 Retrieve 1SE3 in mmCIF format [Save to disk]

View 1SE3 in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1SE3

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1SE3, from MSDmotif at EBI Genome occurence of 1SE3's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1se3_1, region 1-121 [Jmol] [rasmolscript] [script source]     - Domain d1se3_2, region 122-239 [Jmol] [rasmolscript] [script source] Fold representative 1se3 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1se3_A]

Other resources with information on 1SE3

InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

Movements, Movies and Images

Domain movements in 1SE3 from the Database of Macromolecular Movements. Images from IMB Jena Image Library of Biological Macromolecules.

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