1SBB Immune System date Feb 22, 1999
title T-Cell Receptor Beta Chain Complexed With Superantigen Seb
authors H.Li, R.A.Mariuzza
compound source
Molecule: Protein (14.3.D T Cell Antigen Receptor)
Chain: A, C
Fragment: Beta Chain
Engineered: Yes
Mutation: Yes
 Organism_scientific: Mus Musculus
Organism_common: Mouse
Expression_system: Mus Musculus

Molecule: Protein (Staphylococcal Enterotoxin B)
Chain: B, D
Synonym: Seb
Engineered: Yes
Organism_scientific: Staphylococcus Aureus
Strain: Rn9220
Expression_system: Escherichia Coli
symmetry Space Group: P 1 21 1
R_factor 0.228
crystal
cell
length a length b length c angle alpha angle beta angle gamma
71.200 83.650 82.980 90.00 93.04 90.00
method X-Ray Diffractionresolution 2.40 Å
related structures by homologous chain: 1I4X, 1J8H, 1MWA, 1SJE
similarity Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subcellular loc. Secreted protein.
Gene ENTB (S. aureus)
function The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene
Ontology
ChainFunctionProcessComponent
A, C
  • receptor activity

  • membrane
  • integral to membrane
    • D, B
  • pathogenesis
  • extracellular region
    • Primary referenceThree-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B., Li H, Llera A, Tsuchiya D, Leder L, Ysern X, Schlievert PM, Karjalainen K, Mariuzza RA, Immunity 1998 Dec;9(6):807-16. PMID:9881971
    Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (164 Kb) [Save to disk]
  • Biological Unit Coordinates (1sbb.pdb1.gz) 159 Kb
  • CSU: Contacts of Structural Units for 1SBB
  • Likely Quarternary Molecular Structure file(s) for 1SBB
  • Structure Factors (276 Kb)
  • Retrieve 1SBB in mmCIF format [Save to disk]
    • View 1SBB in 3D
  • Proteopedia, because life has more than 2D.
  • On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure.
  • On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz.
  • On AstexViewer, from MSD-EBI (viewer documentation).
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    • Visual 3D analysis of 1SBB
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    • Structure-derived information
  • Electron Density related parameters from EDS Electron Density Server, at Upsala
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Crystal Contacts, from CryCo at Weizmann Institute
  • 3D motif for 1SBB, from MSDmotif at EBI
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1sbba2, region A:118-246 [Jmol] [rasmolscript] [script source]
        - Domain d1sbba1, region A:3-117 [Jmol] [rasmolscript] [script source]
        - Domain d1sbbb1, region B:1-121 [Jmol] [rasmolscript] [script source]
        - Domain d1sbbb2, region B:122-239 [Jmol] [rasmolscript] [script source]
        - Domain d1sbbc2, region C:118-246 [Jmol] [rasmolscript] [script source]
        - Domain d1sbbc1, region C:3-117 [Jmol] [rasmolscript] [script source]
        - Domain d1sbbd1, region D:1-121 [Jmol] [rasmolscript] [script source]
        - Domain d1sbbd2, region D:122-239 [Jmol] [rasmolscript] [script source]
  • Fold representative 1sbb from FSSP and Dali (Families of Structurally Similar Proteins)
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH
  • Summaries and structural analyses of PDB data files from PDBSum
  • Identification of Protein Pockets & Cavities at CASTp
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1sbb_A] [1sbb_C] [1sbb_D] [1sbb_B]
    • Other resources with information on 1SBB
  • InterPro: IPR006123 , IPR007110 , IPR006173 , IPR006177 , IPR006126 , IPR003597
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
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