1RU7	Viral Protein	date	Dec 11, 2003
title	1934 Human H1 Hemagglutinin
authors	J.J.Skehel, S.J.Gamblin, L.F.Haire, R.J.Russell, D.J.Stevens, B.Xiao, Y.Ha, N.Vasisht, D.A.Steinhauer, R.S.Daniels
compound		source
Molecule: Hemagglutinin Chain: A, C, E, G, I, K Other_details: Hemagglutinin Ha1 Chain		Organism_scientific: Influenza A Virus (Apuerto Rico834(H1n1)); Organism_taxid: 211044 Strain: A-Puerto Rico-8-34 Other_details: Bromelain Digested
Molecule: Hemagglutinin Chain: B, D, F, H, J, L Other_details: Hemagglutinin Ha2 Chain		Organism_scientific: Influenza A Virus (Apuerto Rico834(H1n1)); Organism_taxid: 211044 Strain: A-Puerto Rico-8-34
symmetry	Space Group: C 1 2 1	R_factor 0.235 R_Free 0.266
crystal cell	length a length b length c angle alpha angle beta angle gamma 227.515 131.084 174.383 90.00 109.81 90.00
method	X-Ray Diffraction	resolution	2 Å
related structures	by homologous chain: 1JSH, 1RV0, 1RVZ
Gene Ontology	Chain Function Process Component F, A, J, K, E, B, H, C, D, I, G, L host cell surface receptor b... viral envelope fusion with h... Golgi membrane endoplasmic reticulum membra... plasma membrane membrane integral to membrane virion viral envelope host cell plasma membrane endocytic vesicle membrane virion membrane
Primary reference	The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (494 Kb) [Save to disk] Biological Unit Coordinates (1ru7.pdb1.gz) 247 Kb Biological Unit Coordinates (1ru7.pdb2.gz) 248 Kb CSU: Contacts of Structural Units for 1RU7 Likely Quarternary Molecular Structure file(s) for 1RU7 Retrieve 1RU7 in mmCIF format [Save to disk]

View 1RU7 in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1RU7

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1RU7, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1ru7a_, region A [Jmol] [rasmolscript] [script source]     - Domain d1ru7b_, region B [Jmol] [rasmolscript] [script source]     - Domain d1ru7c_, region C [Jmol] [rasmolscript] [script source]     - Domain d1ru7d_, region D [Jmol] [rasmolscript] [script source]     - Domain d1ru7e_, region E [Jmol] [rasmolscript] [script source]     - Domain d1ru7f_, region F [Jmol] [rasmolscript] [script source]     - Domain d1ru7g_, region G [Jmol] [rasmolscript] [script source]     - Domain d1ru7h_, region H [Jmol] [rasmolscript] [script source]     - Domain d1ru7i_, region I [Jmol] [rasmolscript] [script source]     - Domain d1ru7j_, region J [Jmol] [rasmolscript] [script source]     - Domain d1ru7k_, region K [Jmol] [rasmolscript] [script source]     - Domain d1ru7l_, region L [Jmol] [rasmolscript] [script source] Fold representative 1ru7 from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1ru7_J] [1ru7_H] [1ru7_E] [1ru7_D] [1ru7_I] [1ru7_C] [1ru7_G] [1ru7_K] [1ru7_L] [1ru7_B] [1ru7_F] [1ru7_A]

Other resources with information on 1RU7

MMDB (Entrez's Structure Database)

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