1ROJ Histocompatibility Antigen date Jul 19, 1994
title Molecular Dynamics Simulation Of Mhc-Peptide Complexes As A Tool For Predicting Potential Tcell Epitopes
authors D.Rognan, L.Scapozza, G.Folkers, A.Daser
compound source
Molecule: Class I Histocompatibility Antigen (Hla-B2705)
Chain: A
Engineered: Yes

Molecule
Chain: B
Engineered: Yes
methodTheoretical Model
similarity Belongs to the mhc class i family. Belongs to the chaperonin (hsp60) family. Contains 1 ig-like c1-type (immunoglobulin-like) domain.[MHC_I]
subunit Oligomer of 14 subunits composed of two stacked rings of 7 subunits (by similarity). Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin).
induction By stress.
polymorphism The sequence shown is that of b*2701. The following alleles of b-27 are known: b*2701=b*2705, b*2702 (b27.2; b-27k; b27e), b*2703 (b27d), b*2704, b*2706, b*2707, b*2708 (b7qui) and b*2709 (b27-ci).
subcellular loc. Cytoplasm. Membrane; single-pass type i membrane protein.
function This protein is implicated in the pathogenesis of chlamydial disease. Involved in the presentation of foreign antigens to the immune system. Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (by similarity). Inflammation elicited by the 57 kda antigen may damage tissue, with progression to scarring of conjunctival and fallopian tube mucosae, which respectively result in blindness and infertility.
Primary referenceMolecular dynamics simulation of MHC-peptide complexes as a tool for predicting potential T cell epitopes., Rognan D, Scapozza L, Folkers G, Daser A, Biochemistry 1994 Sep 27;33(38):11476-85. PMID:7522551
Data retrieval
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