1QWM | Oxidoreductase | date | Sep 02, 2003 ![]() |
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title | Structure Of Helicobacter Pylori Catalase With Formic Acid Bound | ||||||||||||||
authors | P.C.Loewen, X.Carpena, R.Perez-Luque, C.Rovira, R.Haas, S.Odenbreit, P.Nicholls, I.Fita | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Kata Catalase Chain: A, B Ec: 1.11.1.6 Engineered: Yes |
Organism_scientific: Helicobacter Pylori Organism_common: Bacteria Gene: Kata (Hp0875) Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Um255 Expression_system_vector_type: Plasmid Expression_system_plasmid: Pso100 | ||||||||||||||
symmetry | Space Group: P 21 21 2 | R_factor | 0.194 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 1.60 Å | ||||||||||||
ligand | AZI, FMT, HEM | enzyme | Catalase;. Equilase;. Caperase;. Optidase;. Catalase-peroxidase;. CAT. Oxidoreductase E.C.1.11.1.6 BRENDA | ||||||||||||
similarity | Belongs to the Catalase family. | ||||||||||||||
catalytic activ. | 2 h(2)o(2) = o(2) + 2 h(2)o. | ||||||||||||||
subcellular loc. | Cytoplasm (probable). | ||||||||||||||
genes | CAT (B. taurus); katE, katG (E. coli); perA (H. marismortui); katA (H. pylori); CAT (H. sapiens); katA (M. luteus); MT1959, katG (M. tuberculosis); cat-1 (N. crassa); katA (P. mirabilis); katB (P. syringae); CTA1 (S. cerevisiae) | ||||||||||||||
function | Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. | ||||||||||||||
Gene Ontology | |||||||||||||||
disease | Acatalasemia Glycine N-Acyltransferase; Glyat | ||||||||||||||
Primary reference | Structure of Helicobacter pylori catalase, with and without formic acid bound, at 1.6 A resolution., Loewen PC, Carpena X, Rovira C, Ivancich A, Perez-Luque R, Haas R, Odenbreit S, Nicholls P, Fita I, Biochemistry 2004 Mar 23;43(11):3089-103. PMID:15023060 |
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Structure-derived information |
- Domain d1qwma_, region A [Jmol] [rasmolscript] [script source] - Domain d1qwmb_, region B [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
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