1QIL	Toxin	date	Mar 27, 1997
title	Inactive Mutant Toxic Shock Syndrome Toxin-1 At 2.5 A
authors	K.R.Acharya, A.C.Papageorgiou
compound		source
Molecule: Toxic Shock Syndrome Toxin-1 Chain: A, B, C Synonym: Tsst-1 Engineered: Yes Mutation: Yes		Organism_scientific: Staphylococcus Aureus Expression_system: Escherichia Coli Expression_system_vector_type: Bacterial Expression_system_vector: Pezz18 Expression_system_plasmid: Puc19
symmetry	Space Group: C 2 2 21	R_factor	0.202
crystal cell	length a length b length c angle alpha angle beta angle gamma 109.030 177.450 97.510 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.50 Å
related structures	by homologous chain: 1TS2, 4TSS
similarity	Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc.	Secreted protein.
Gene	TST (S. aureus)
function	Responsible for the symptoms of toxic shock syndrome.
Gene Ontology	Chain Function Process Component A, C, B pathogenesis extracellular region
Primary reference	Crystal structure of a biologically inactive mutant of toxic shock syndrome toxin-1 at 2.5 A resolution., Papageorgiou AC, Quinn CP, Beer D, Brehm RD, Tranter HS, Bonventre PF, Acharya KR, Protein Sci 1996 Aug;5(8):1737-41. PMID:8844860

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (100 Kb) [Save to disk] Biological Unit Coordinates (1qil.pdb1.gz) 36 Kb Biological Unit Coordinates (1qil.pdb2.gz) 33 Kb Biological Unit Coordinates (1qil.pdb3.gz) 33 Kb CSU: Contacts of Structural Units for 1QIL Likely Quarternary Molecular Structure file(s) for 1QIL Retrieve 1QIL in mmCIF format [Save to disk]

View 1QIL in 3D

Proteopedia, because life has more than 2D. On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1QIL

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1QIL, from MSDmotif at EBI Genome occurence of 1QIL's fold from GeneCensus Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1qila1, region A:1-93 [Jmol] [rasmolscript] [script source]     - Domain d1qila2, region A:94-194 [Jmol] [rasmolscript] [script source]     - Domain d1qilb1, region B:1-93 [Jmol] [rasmolscript] [script source]     - Domain d1qilb2, region B:94-194 [Jmol] [rasmolscript] [script source]     - Domain d1qilc1, region C:1-93 [Jmol] [rasmolscript] [script source]     - Domain d1qilc2, region C:94-194 [Jmol] [rasmolscript] [script source] Fold representative 1qil from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1qil_A] [1qil_B] [1qil_C]

Other resources with information on 1QIL

InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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